Repaglinide

Manufactured by Novo Nordisk

Sourced in Denmark

Repaglinide is a laboratory medication used for the treatment of type 2 diabetes. It functions as an antidiabetic agent by stimulating the release of insulin from the pancreatic beta cells.

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Lab products found in correlation

Pepsin, by Maclin Biochemical Technology (1 mentions) Trypsin, by Meilun (1 mentions) Poloxamer 188 f68, by BASF (1 mentions)

2 protocols using repaglinide

Repaglinide Solubility Enhancement Formulation

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Repaglinide raw material was obtained from Tianjin Jinkang Pharmaceutical Ltd. (Tianjin, China). The commercial tablet of Repaglinide was purchased from Novo Nordisk Co. (Bagsvaerd, Denmark). MCT was obtained from Lipoid GMBH (Ludwigshafen, Germany). Glycerin monostearate and Tween 80 were purchased from Tianjin Bodi Chemical Company (Tianjin, China). Poloxamer 188 (F68) was provided by BASF SE (Shanghai, China). Sodium dodecyl sulfate (SDS) was obtained from Anhui Shanhe Pharmaceutical Excipients Co., Ltd. (Huainan, China). Pepsin was purchased from Shanghai Macklin Biochemical Co., Ltd. (Shanghai, China). Trypsin was obtained from Dalian Meilun Biological Technology Co., Ltd. (Dalian, China). All other reagents used in this study were high-performance liquid chromatography (HPLC) grade.

Wu L., Zhao L., Su X., Zhang P, & Ling G. (2019). Repaglinide-loaded nanostructured lipid carriers with different particle sizes for improving oral absorption: preparation, characterization, pharmacokinetics, and in situ intestinal perfusion. Drug Delivery, 27(1), 400-409.

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Repaglinide Effects on T2DM Patients

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T2DM patients received repaglinide (trade name: Novo; Novo Nordisk, Copenhagen, Denmark) 1 mg at 15 minutes before meals orally 3 times a day for 8 weeks. During treatment, their diet and exercise habits remain unchanged. Antihypertensive drugs or hypolipidemic drug users continued to take their current medications with the dose unchanged. Venous blood samples were collected after fasting overnight and again 2 hours after a standard breakfast (100 g sugar-free steamed bread). Parameters were measured before and eight weeks after repaglinide administration.

Zhou X., Chen C., Yin D., Zhao F., Bao Z., Zhao Y., Wang X., Li W., Wang T., Jin Y., Lv D., Lu Q, & Yin X. (2019). A Variation in the ABCC8 Gene Is Associated with Type 2 Diabetes Mellitus and Repaglinide Efficacy in Chinese Type 2 Diabetes Mellitus Patients. Internal Medicine, 58(16), 2341-2347.

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