Log In Sign up
The largest database of trusted experimental protocols

Inveon micro pet ct rodent model scanner

Manufactured by Siemens
Visit Supplier
Sourced in Germany

The Inveon micro-PET/CT rodent model scanner is a preclinical imaging system designed for imaging small animals, such as rodents. The device combines positron emission tomography (PET) and computed tomography (CT) technologies to provide high-resolution, three-dimensional images of the subject's anatomy and function.

Automatically generated - may contain errors

Lab products found in correlation

Gamma counter, by PerkinElmer (3 mentions) Inveon research workplace software, by Siemens (1 mentions)

Close spelling variants of this product

Inveon Micro-CT/PET scanner Inveon Micro-CT/PET Inveon PET/CT scanner Inveon rodent model scanner Inveon micro-CT scanner Micro-PET/CT scanner Inveon PET/CT Inveon Micro-CT Inveon PET scanner Inveon CT scanner

5 protocols using inveon micro pet ct rodent model scanner

1

In-vivo PET Imaging of DTN Biodistribution

Check if the same lab product or an alternative is used in the 5 most similar protocols
A 60-min dynamic PET imaging was performed to monitor the biodistribution process of DTN in vivo. PET scans were carried out on an Inveon micro-PET/CT rodent model scanner (Siemens Medical Solutions, Erlangen, Germany). Mice were anesthetized under 2%–3% isoflurane and the tail veins were catheterized, PET images were acquired while 50 μCi (1.85 MBq) of 64Cu-DTN was intravenously injected into female ICR (CD-1®) Outbred mice (ICR mice, Envigo, Madison, WI, USA). The histogram file was reframed a total of 40 frames: 10 s × 6 frames, 20 s × 6 frames, 30 s × 6 frames, 60 s × 6 frames, and 180 s × 16 frames. Ordered subsets expectation maximization 3D or maximum a posteriori (OSEM3D/MAP) was used as the reconstruction algorithm.
Jiang D., Im H.J., Boleyn M.E., England C.G., Ni D., Kang L., Engle J.W., Huang P., Lan X, & Cai W. (2018). Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function. Nano research, 12(3), 637-642.
+ Open protocol
+ Expand
2

In Vivo Imaging of Kidney Injury

Check if the same lab product or an alternative is used in the 5 most similar protocols
Following 89Zr labeling of SeCQDs, 80–120 µCi (2.96‐4.44 MBq) of 89Zr‐DFO‐SeCQDs was administered intravenously to ICR mice that were either healthy or had AKI induced by either 50% glycerol or cisplatin (n = 3). Longitudinal positron emission tomography (PET) scans were obtained using an Inveon microPET/CT rodent model scanner (Siemens Healthineers, Germany). At the time point of interest, mice were anesthetized with isoflurane (2% in oxygen) and placed on the bed of the PET scanner. During the initial three time‐points (5 min, 1 h, 4 h) p.i., 40 million coincidence events were collected whereas 30 million were collected for the remaining. PET data was reconstructed by 3D ordered‐subset expectation maximization followed by maximum a posteriori reconstruction (OSEM3D/MAP) and decay corrected using the Inveon Research Workplace software (Siemens Healthineers, Germany). Region‐of‐interests were drawn at each time‐point to quantify the biodistribution in each tissue of interest (blood, liver, spleen, kidney, bone). After the PET scan at the terminal time‐point, the mice were euthanized, and the organs were collected to quantify biodistribution ex vivo using a gamma counter (Perkin Elmer, USA). SeCQDs uptake in tissue was determined as a percentage of the injected dose per gram of tissue (%ID/g).
Rosenkrans Z.T., Sun T., Jiang D., Chen W., Barnhart T.E., Zhang Z., Ferreira C.A., Wang X., Engle J.W., Huang P, & Cai W. (2020). Selenium‐Doped Carbon Quantum Dots Act as Broad‐Spectrum Antioxidants for Acute Kidney Injury Management. Advanced Science, 7(12), 2000420.
+ Open protocol
+ Expand
3

In Vivo PET Imaging of 64Cu-DTN

Check if the same lab product or an alternative is used in the 5 most similar protocols
A 30-min dynamic PET imaging was performed to monitor the biodistribution process of DTN in vivo. PET scans were carried out on an Inveon micro-PET/CT rodent model scanner (Siemens Medical Solutions, Erlangen, Germany). Mice were anesthetized under 2%–3% isoflurane and the tail veins were catheterized, PET images were acquired while 50 μCi (1.85 MBq) of 64Cu-DTN was intravenously injected into female ICR mice. The histogram file was reframed a total of 28 frames: 10 s × 6 frames, 30 s × 6 frames, 60 s × 6 frames, and 120 s × 10 frames. Ordered subsets expectation maximization 3D or maximum a posteriori (OSEM3D/MAP) was used as the reconstruction algorithm. Region-of-interest (ROI) analysis was performed to quantify the time-activity curve for organs of interest. Tracer accumulation was expressed as %ID/g. An image-based estimation of the arterial concentration of 64Cu-DTN from ROI results of the heart was employed to determine the PK of the tracer.
Jiang D., Im H.J., Boleyn M.E., England C.G., Ni D., Kang L., Engle J.W., Huang P., Lan X, & Cai W. (2018). Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function. Nano research, 12(3), 637-642.
+ Open protocol
+ Expand
4

64Cu-NOTA-pertuzumab Tumor Uptake Imaging

Check if the same lab product or an alternative is used in the 5 most similar protocols
PET imaging was performed on the Inveon micro-PET/CT rodent model scanner (Siemens Medical Solutions, Erlangen, Germany). Tumor-bearing mice were intravenously (i.v.) injected with 5–10 MBq of 64Cu-NOTA-pertuzumab or 64Cu-NOTA-IgGNonspecific, and PET scans were conducted at 3, 24, and 48 h after injection. For orthotopic groups, PET/CT scans were performed at the last time point. Following the terminal PET or PET/CT scan, mice were sacrificed, and organs of interest were harvested to validate the imaging data. A gamma counter (PerkinElmer, Waltham, MA, USA) was used to quantify tracer uptake in various tissues and organs, and accumulations were denoted by percentage of injected dose per gram of tissue (%ID/g; ≥ 3 mice per group).
Jiang D., Im H.J., Sun H., Valdovinos H.F., England C.G., Ehlerding E.B., Nickles R.J., Lee D.S., Cho S.Y., Huang P, & Cai W. (2017). Radiolabeled pertuzumab for imaging of human epidermal growth factor receptor 2 expression in ovarian cancer. European journal of nuclear medicine and molecular imaging, 44(8), 1296-1305.
+ Open protocol
+ Expand
5

Pharmacokinetics of Zirconium-89 Labeled Antibody Probes

Check if the same lab product or an alternative is used in the 5 most similar protocols
The mice bearing tumor (subcutaneous (S.C.) and orthotopic model) was intravenously administered with 5.5 ~ 7.4 MBq of 89Zr-DFO-AF650 or 89Zr-DFO-IgG and scanned on an Inveon micro-PET/CT rodent model scanner (Siemens Medical Solutions) at several intervals (4, 24, 48, 72, 96, and 120 h) post injection. After 5-day scanning, the major organs (e.g., the heart, spleen, kidney, liver, and tumor) were harvested for quantification of the tracer accumulated on PET/CT scanner or a gamma counter (PerkinElmer). The biodistribution (BioD) among organs was analyzed and presented as a percentage of injected dosage/gram of organ (%ID/g). Size of tumor was calculated by following formula: 1/2(length × width2). The region of interest (ROI) were drawn on key tissues (including the heart, spleen, kidney, liver, tumor, and muscle) for studying the pharmacokinetics of 89Zr-DFO-AF650. The linear regression (ROI and BioD) and heat map (ROI) analysis were also performed for further confirmations of the correlation (ROI and BioD) and ROI significance among Trop-2-positive and Trop-2-negative groups.
Chen W., Li M., Younis M.H., Barnhart T.E., Jiang D., Sun T., Lang J.M., Engle J.W., Zhou M, & Cai W. (2021). ImmunoPET of trophoblast cell-surface antigen 2 (Trop-2) expression in pancreatic cancer. European journal of nuclear medicine and molecular imaging, 49(3), 861-870.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!