Ge750

T₁-weighted data were obtained on multiple 3T scanners in the ABCD Study (Siemens Prisma, General Electric (GE) 750 and Philips) and one scanner in the Generation R Study (GE 750). Standard adult-sized coils were used for the ABCD Study and an eight-channel receive-only head coil for the Generation R Study. To acquire T₁-weighted structural images, the ABCD Study used an inversion prepared RF-spoiled gradient echo scan with prospective motion correction while the Generation R Study used an inversion recovery fast spoiled gradient recalled sequence (GE option = BRAVO, TR = 8.77 ms, TE = 3.4 ms, TI = 600 ms, flip angle = 10°, matrix size = 220 × 220, field of view = 220 × 220 mm, slice thickness = 1 mm, number of slices = 230, ARC acceleration factor = 2). More details can be found elsewhere (Casey et al., 2018 (link); Hagler et al., 2019 (link); White et al., 2018 (link)). Of note, in the ABCD Study, a technical mistake occurred at one collection site, causing the hemisphere data to be flipped. This was fixed before processing.

MRI examination was performed on a 3‐T MRI scanner (GE750, GE Healthcare, Waukesha, WI), using a dedicated 8‐channel knee coil (Invivo Inc., Gainesville, FL). The patients were in the supine position with the knee extended. The sequences obtained during MRI imaging were Sagittal 3D T1 weighed SPGR (TR/ TE 6.3 ms/3.1 ms), Sagittal FS PDWI (TR/TE 2228 ms/22.0 ms), Coronal FS PDWI (TR/TE 1846 ms/26.5 ms), and Traverse STIR T2WI (TR/TE 4000 ms/100.6 ms) at 1‐mm slice thickness and increment, respectively. Respective fields of view were adjusted to patient anatomy and size.
DR manufactured by GE is equipped with a bracket holding 41 cm × 41 cm cassettes, and a 41 cm × 128 cm locating plate, and a 41 cm × 128 cm anti‐scatter grid. Patients receiving DR examination were in the standing position⁸, with the film distance of 1.8 m, and the exposure condition of 70–75 kV, gamma ray exposure of 20–25 mas. The knee joint horizontal position was taken as the center, and the film was exposed in one time. The obtained figures and data were processed with the computer full‐leg software system into the full‐length image of lower limbs. The patients were in the supine position, with the knee joint at the affected side straightened, the kneecap facing the front, the film distance of 1 m, and the exposure condition of 50 MV.

The fMRI data were acquired using a 3.0T GE 750 scanner (General Electric, Waukesha, WI USA) at UESTC with the gradient-recalled echo-planar imaging (EPI) sequence. An 8-channel prototype quadrature birdcage head coil fitted with foam padding was applied to minimize the head motion. The imaging parameters were as follows: repetition time/echo time = 2000 ms/30 ms, 90° flip angle, 64 × 64 matrix, 22 cm field of view, 43 axial slices (3.2 mm slice thickness without gap).

Brain images were obtained using a 3.0T MRI (GE 750, Waukesha, WI, USA) with a 32-channel head coil covering the whole brain. The experimental protocol included DTI images, as well as T1 and T2-weighted images.
The main sequences were performed with the following parameters:
(1)

DTI sequence: echo time (TE) = minimum, repetition time (TR) = 10,000, field of view (FOV) 240 mm, matrix 128 mm × 128 mm, slice thickness 3.0 mm, b-value = 1000, number of slices = 44, number of directions = 25, and 0 skip between slices.

(2)

Three-dimensional T1-weighted magnetization-fast spoiled gradient recalled echo (T1WI 3D-FSPGR) images: TE = min/full, flip angle 8°, slice thickness 1.2 mm, rep time = 900, matrix 256 mm × 256 mm, and 0 skip between slices. High-resolution T1-weighted images were obtained for VBM analyses.

Two 3.0T MRI scanners (GE750 [GE Healthcare] and Ingenia Elition [Philips]) were used to perform prostate mpMRI. The MRI protocol encompassed axial T1-weighted images; axial, sagittal, and coronal T2-weighted images (T2WI) (3-mm slice thickness); axial diffusion-weighted images (DWI) (3-mm slice thickness; b-values: 0, 100, 800, 1000, 1500, and 2000 s/mm²) and corresponding apparent diffusion coefficient (ADC) maps; and dynamic contrast-enhanced images (DCE) (3-mm slice thickness). The detailed MRI acquisition parameters applied in this study are shown in Supplementary S-Table 1.