MRI was performed at both 1.5T (Siemens Espree, Siemens Magnetom Avanto, GE Signa Excite, GE Signa HDx) and 3T (GE Signa HDx, GE Signa Excite). Conventional MRI included pre-contrast T1w, T2-weighted, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging.11 (link) For both pre- and post-contrast T1w imaging, all sites were required to collect the data using a spin-echo sequence with the following parameter ranges: TE/TR = min (<15 ms)/400–600 ms, FOV=220–240 mm, phase FOV = 75%, slice thickness/gap = 5 mm/1 mm, matrix = 256 × 256, NEX = 1. The imaging protocol remained fixed at each site and across all time points. Following i.v. of 0.1 mmol/kg of a standard gadolinium-based contrast agent (The brand used was dictated by each site’s preference.), axial 2D spin-echo (2D-T1) and 3D volumetric T1w post-contrast images were acquired. Patients participating in the optional advanced component of the trial had dynamic contrast-enhanced, dynamic susceptibility contrast (DSC), and/or spectroscopic MRI at baseline, week 2, and after every two cycles of treatment. Results from these advanced imaging cohorts were previously reported.12 (link)–14 (link) A complete listing of all MRI parameters for this protocol can be found on the ACRIN website. (https://www.acrin.org/PROTOCOLSUMMARYTABLE/PROTOCOL6677/6677ImagingMaterials.aspx ).
Ge signa hdx
Manufactured by GE Healthcare
Sourced in United States
The GE Signa HDx is a high-performance magnetic resonance imaging (MRI) system designed for clinical use. It provides high-quality imaging capabilities for a wide range of diagnostic applications. The system features advanced imaging technology and a user-friendly interface to assist healthcare professionals in their clinical decision-making process.
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Lab products found in correlation
Ingenia, by GE Healthcare (2 mentions)
Triotim, by GE Healthcare (2 mentions)
Ge signa excite, by GE Healthcare (2 mentions)
Omniscan, by GE Healthcare (2 mentions)
Eight channel phased array head coil, by GE Healthcare (1 mentions)
Tecnai g20, by Thermo Fisher Scientific (1 mentions)
Magnetom avanto, by GE Healthcare (1 mentions)
Ge genesis, by GE Healthcare (1 mentions)
Intera, by Philips (1 mentions)
Multihance, by Bracco (1 mentions)
Dotarem, by Guerbet (1 mentions)
Magnetom verio, by Siemens (1 mentions)
Eight channel abdominal array and endorectal coil, by Bayer (1 mentions)
Achieva, by GE Healthcare (1 mentions)
Ge discovery mr750, by GE Healthcare (1 mentions)
Signa hdx scanner, by GE Healthcare (1 mentions)
8 channel head coil, by GE Healthcare (1 mentions)
Ge signa hd, by GE Healthcare (1 mentions)
Omnipaque, by GE Healthcare (1 mentions)
Lightspeed ct simulator, by GE Healthcare (1 mentions)
24 protocols using ge signa hdx
1
MRI Imaging Protocol for Cancer Trials
2
MRI Imaging of Iron-Labeled Cells and Tumors
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Cells were grown in medium supplemented with FAC (1 mM) for 48 h before MR imaging. After thorough washing with PBS to remove extracellular iron, dissociating with trypsin, and fixing in 4 % PFA for 10 min, the cells were suspended in 1 ml PBS and transferred into 2-ml microcentrifuge tubes (5 × 107 cells/tube), which were precoated with 500 μl 1 % agarose. After the cells had settled for 20–30 min and formed a loose pellet on the top of the agarose, MRI was performed with a 3.0-T MR unit with a knee coil (GE Signa HDx). T2*-weighted images were acquired using a GRE (gradient recalled echo) sequence with the following parameters: TR (repetition time) = 400 ms, TE (echo time) = 12 ms, flip angle = 30° and slice thickness = 1.0 mm. In a second GRE acquisition, R2* measurements were derived from eight images using the following parameters: TR = 1000 ms, TE = 2.5–27.0 ms (8 echoes) and slice thickness = 2.2 mm.
Tumours were imaged 15 days after virus injection using a 1.5-T MR scanner (GE Signa HDx). Mice were anaesthetized with 2 % sodium pentobarbital and placed in a wrist coil. T2-weighted images of tumours were obtained using an FSE (fast spin echo) sequence (TR = 2000 ms, TE = 47.5 ms, FOV (field of view) = 6 × 6 cm and slice thickness = 2.0 mm). T2*-weighted images were obtained using a GRE sequence (TR = 540 ms, TE = 10 ms, FOV = 6 × 6 cm and slice thickness = 2.0 mm).
Tumours were imaged 15 days after virus injection using a 1.5-T MR scanner (GE Signa HDx). Mice were anaesthetized with 2 % sodium pentobarbital and placed in a wrist coil. T2-weighted images of tumours were obtained using an FSE (fast spin echo) sequence (TR = 2000 ms, TE = 47.5 ms, FOV (field of view) = 6 × 6 cm and slice thickness = 2.0 mm). T2*-weighted images were obtained using a GRE sequence (TR = 540 ms, TE = 10 ms, FOV = 6 × 6 cm and slice thickness = 2.0 mm).
3
3T MRI Protocol for Brain Imaging
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MR images and spectra were acquired using a 3.0T GE Signa HDx whole body, long bore MR scanner (GE Healthcare, Waukesha, WI, USA) at the Brain Imaging Center, University of Colorado Denver. Subjects were imaged in the supine position using a GE eight-channel phased array head coil. To comply with age- and population-related behaviors such as boredom and restlessness, subjects watched a movie during the exams using MR-compatible goggles and headphones (Resonance Technology Inc., Northridge, CA, USA) during the procedure. A T1-weighted sequence was acquired for tissue segmentation using a 3D inversion recovery fast, spoiled gradient echo (IR-SPGR) technique (matrix 256 x 256, FOV 22 cm, TR/TE/TI= 10/3/450 ms, NEX=1), resulting in 168 1.2 mm thick axial slices with an in-plane resolution of .86 mm2.
4
Multiparametric MRI Characterization of SiO2 Nanoparticles
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The T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), T1 map, and T2 map of SSM with different SiO2 thickness and in different pH environment (incubated 24 h) were measured on a 3.0 T MRI scanner (GE signa HDx, USA).
The acquisition parameters were set as:
T1WI, repetition time (TR) = 500 ms, echo time (TE) = 12 ms, slice thickness = 1 mm, slice spacing = 1 mm, FOV = 10 × 10 cm, matrix = 256 × 256;
T1 Map images, TR = 4.0 ms, TE = 2.0 ms, slice thickness = 1 mm, slice spacing = 1 mm, FOV = 10 × 10 cm, matrix = 256 × 256;
T2WI, TR = 2500 ms, TE = 60 ms, slice thickness = 1 mm, slice spacing = 1 mm, FOV = 10 × 10 cm, matrix = 256 × 256;
T2 Map images, TR = 1000 ms, TE = 12 − 180 ms, slice thickness = 1 mm, slice spacing = 1 mm, FOV = 10 × 10 cm, matrix = 256 × 256.
Quantitative T1 and T2 relaxation maps were reconstructed from datasets via Paravision 4 software. The same method was applied for the pH sensitivity evaluation of SSM in different pH conditions.
The acquisition parameters were set as:
T1WI, repetition time (TR) = 500 ms, echo time (TE) = 12 ms, slice thickness = 1 mm, slice spacing = 1 mm, FOV = 10 × 10 cm, matrix = 256 × 256;
T1 Map images, TR = 4.0 ms, TE = 2.0 ms, slice thickness = 1 mm, slice spacing = 1 mm, FOV = 10 × 10 cm, matrix = 256 × 256;
T2WI, TR = 2500 ms, TE = 60 ms, slice thickness = 1 mm, slice spacing = 1 mm, FOV = 10 × 10 cm, matrix = 256 × 256;
T2 Map images, TR = 1000 ms, TE = 12 − 180 ms, slice thickness = 1 mm, slice spacing = 1 mm, FOV = 10 × 10 cm, matrix = 256 × 256.
Quantitative T1 and T2 relaxation maps were reconstructed from datasets via Paravision 4 software. The same method was applied for the pH sensitivity evaluation of SSM in different pH conditions.
5
3T MRI Hippocampus Segmentation Protocol
6
Resting-State fMRI Acquisition Protocol
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Each participant received a resting-state scan in a 3.0-T scanner (GE Signa HDx, General Electric, US) with the head fixed by foam pads to minimize head motion. T1-weighted structural images were acquired with a three-dimensional spoiled-gradient recalled-acquisition sequence (3D-SPGR, Time of Repetition, 7.876 ms; Time of Echo, 3.06 ms; slice thickness, 1.2 mm; field of view, 22 cm × 22 cm; resolution, 1 × 1 × 1 mm3; Time of inversion, 400 ms). T2*-weighted functional imaging was performed using an echo planar imaging sequence (EPI, Time of Repetition, 2000 ms; Time of Echo, 22.5 ms; slice thickness, 4.0 mm; field of view, 22 cm × 22 cm; skip between slices, 0.6 mm; matrix, 64 × 64; flip angle, 30 °C; voxel size, 3.75 × 3.75 × 4 mm3). For each participant, 33 axial slices without gaps were obtained in an interleaved-ascending order covering the entire brain, and resting-state fMRI data (240 volumes, 8 min) was collected.
7
Characterization of Anti-EGFR-PEG-SPIO Nanoparticles
8
Resting-State fMRI Acquisition Protocol
9
EMBARC MRI Acquisition Protocol
10
resting-state fMRI data acquisition
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Functional magnetic resonance imaging (fMRI) data were obtained while participants rested with eyes closed using a T2* weighted gradient echo spiral pulse sequence: TR = 2000 ms, TE = 30 ms, flip angle = 80°, and 1 interleave, FOV = 22 cm, matrix = 64 × 64, in-plane resolution = 3.4375 mm2, number of volumes = 216 with a 3 T GE Signa HDx whole body scanner (GE Medical Systems, Milwaukee, WI). A high-order shimming method was employed to reduce field heterogeneity. A high-resolution, 3D IR-prepared FSPGR anatomic scan was obtained: TR: 8.5, TE: minimum, flip: 15 degrees, TI: 400 ms, BW: + / − 31.25 kHz, FOV: 22 cm, phase FOV: 0.75, slice thickness: 1.5 mm, 124 slices, 256 × 256 @ 1 NEX, scan time: 4:33 min.
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