The hsCRP was analysed using an automated colorimetric immunoassay on a Dade Behring Dimension RXL autoanalyzer (Siemens Healthcare, Camberly, Surrey, UK), glucose was assayed by an enzymatic method utilizing hexokinase (Cobas 8000 automatic c702-analyzer, Roche Diagnostics GmbH, Mannheim, Germany), and insulin was determined with an immunoelectrochemiluminometric assay (a modular E170 automatic analyzer, Roche Diagnostics GMbH, Mannheim, Germany) in an accredited Turku University Hospital Laboratory which has a quality control system. HOMA2-IR was calculated from fasting plasma glucose and fasting insulin using a HOMA calculator (http://www.dtu.ox.ac.uk/ ) [22 ]. GlycA and lipids were quantified from serum samples using a commercial high-throughput proton NMR, metabolomics platform (Nightingale Health Ltd., Helsinki, Finland) as previously described [23 ]. GlycA is a composite nuclear magnetic resonance (NMR) biomarker of systemic inflammation and consists of N-acetyl sugar groups originating from multiple acute phase circulating glycoproteins: α1-acid glycoprotein, haptoglobin, α1-antitrypsin, α1-antichymotrypsin and transferrin.
Cobas 8000 automatic c702 analyzer
Manufactured by Roche
The Cobas 8000 automatic c702-analyzer is a laboratory instrument manufactured by Roche. It is designed to perform automated clinical chemistry analysis of various biological samples. The core function of the Cobas 8000 c702-analyzer is to analyze and measure the concentrations of different analytes in patient samples, providing healthcare professionals with accurate and reliable data for diagnostic and treatment purposes.
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Lab products found in correlation
2 protocols using cobas 8000 automatic c702 analyzer
1
Quantification of Inflammatory Biomarkers
2
Glucose, Insulin, and HbA1c Measurement Protocol
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The glucose concentration was measured using an enzymatic method utilizing hexokinase (Cobas 8000 automatic c702-analyzer, Roche Diagnostics, Mannheim, Germany), the insulin concentration with an immunoelectrochemiluminometric assay (a modular E170 automatic analyzer, Roche Diagnostics, Mannheim, Germany), glycated haemoglobin (HbA1c) by ionexchange HPLC (Bio-Rad Variant II Haemoglobin A1c Program, Bio-Rad Laboratories, Marnes-la-Coquette, France) and insulin resistance was estimated with the homeostatic model assessment-method (HOMA2-IR) using HOMA calculator (http://www.dtu.ox.ac.uk/) 15 .
Glucose concentration below value of 5.3 mmol/l, insulin values below 26 mU/I and HAbc1 levels under 6.5 % were considered within reference limits.
Glucose concentration below value of 5.3 mmol/l, insulin values below 26 mU/I and HAbc1 levels under 6.5 % were considered within reference limits.
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