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Anhydrous ch3cn

Manufactured by Merck Group
Sourced in Germany, Japan

Anhydrous CH3CN is a laboratory-grade solvent commonly used in chemical and analytical applications. It is a clear, colorless liquid with a low boiling point. The chemical formula is CH3CN, representing acetonitrile, a polar aprotic solvent. Anhydrous CH3CN is typically used for various purposes in research and industrial settings, such as sample preparation, extraction, and chromatographic analysis.

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3 protocols using anhydrous ch3cn

1

Oxygen-18 Labeled Manganese Complex Synthesis

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All reagents were of commercial
grade (Sigma-Aldrich, TCI) and were used as received unless stated
otherwise. H2O2: Sigma-Aldrich, 50 wt %. H218O: Rotem Industries Ltd., 98%. Anhydrous CH3CN (Sigma-Aldrich): 99.8%, <0.005% H2O (3 mM).
The 1.5 M Na18OH (in H218O) was prepared
by adding a piece of Na metal (33 mg, 0.29 mmol) to 1.0 mL of H218O. The mixture of 1 M H2O2 and 1.5 M Na18OH in H218O was prepared
by mixing a solution of 50 wt % H2O2 (13 μL)
and H218O (250 μL) with the previously
prepared 1.5 M Na18OH (aq.; 200 μL). [Mn2(μ-O)3(tmtacn)2](PF6)2·H2O (1) was generously supplied
by Catexel Ltd., and it was analyzed by elemental analysis (calcd
for Mn2C18H44N6O4P2F12): C, 26.82% (26.74%); H, 5.39% (5.49%);
N, 10.40% (10.40%).
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2

Radiolabeled Fluorine-19 Compound Synthesis

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The precursor DPA-SPIAD and the standard compound [19F]FDPA were purchased from Shenzhen PET-BiO Technology Co., Ltd. (China). Tetrabutylammonium methanesulfonate (TBAOMs), anhydrous CH3CN, and 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195) were purchased from Sigma-Aldrich (Germany). O-18 enriched water (purity ≥ 98%) was purchased from Jiangsu Huayi Technology Co., Ltd (China). Other chemicals and reagents were purchased from commercial supplies, without further purification.
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3

Neuroimaging of Rhesus Monkeys

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Twelve young-adult male rhesus monkeys (Macaca mulatta: age range, 7.1-9.4 y old; weight range, 4.0-6.0 kg) were maintained and handled in accordance with the recommendations of the U.S. National Institutes of Health and the guidelines of the Central Research Laboratory, Hamamatsu Photonics K.K. The experiments were approved by the Ethical Committee of the Central Research Laboratory, Hamamatsu Photonics K.K. (approval HPK-2015-15) .
MR images of the monkeys were obtained with a 3.0-T scanner (Signa Excite HDxt 3.0T; GE Healthcare Japan) using a 3-dimensional spoiled gradient echo sequence under pentobarbital anesthesia.
Kryptofix222 and K 2 CO 3 Á1.5H 2 O were from Merck Milipore. Anhydrous CH 3 CN, dimethylformamide, dimethyl sulfoxide, silver trifluoromethanesulfonate, Tris(dibenzyldeneacetone)dipalladium(0), trio-tolylphosphine, and MPTP were from Sigma-Aldrich Japan. Precursors of 11 C-DASB, 18 F-MPPF, 6-11 C-methyl-m-tyrosin ( 11 C-6MemTyr), 11 Craclopride, 11 18 F-BCPP-EF, and their corresponding standard compounds were from NARD Institute Ltd.
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