In the telaprevir group, all patients received combination therapy with peginterferon α-2b (1.0-1.5 μg/kg) weekly (MSD, Tokyo, Japan), ribavirin (MSD) and telaprevir (1,500 mg or 2,250 mg daily) (Tanabe-Mitsubishi, Tokyo, Japan) for 12 weeks, followed by 12 weeks of peginterferon α-2b and ribavirin. In the simeprevir group, patients received a combination treatment of simeprevir (100 mg daily) (Janssen Pharmaceutical K.K., Tokyo, Japan), peginterferonα-2a (180 μg) (Chugai, Tokyo, Japan) or peginterferon α-2b (1.0-1.5 μg/kg) weekly and ribavirin (MSD or Chugai) for 12 weeks, followed by 12 weeks of peginterferon α-2a or peginterferon α-2b and ribavirin. ribavirin was given orally at a daily dose of 400-1,000 mg based on body weight.
Kanda T., Nakamoto S., Sasaki R., Nakamura M., Yasui S., Haga Y., Ogasawara S., Tawada A., Arai M., Mikami S., Imazeki F, & Yokosuka O. (2016). Sustained Virologic Response at 24 Weeks after the End of Treatment Is a Better Predictor for Treatment Outcome in Real-World HCV-Infected Patients Treated by HCV NS3/4A Protease Inhibitors with Peginterferon plus Ribavirin. International Journal of Medical Sciences, 13(4), 310-315.
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