1 1 1 3 3 3 hexafluoroisopropyl alcohol

Manufactured by Chem-Impex

Sourced in United States

1,1,1,3,3,3-Hexafluoroisopropyl alcohol is a laboratory chemical compound with the molecular formula C3H3F6O. It is a clear, colorless liquid with a high boiling point and low volatility. The compound is commonly used as a solvent, reagent, and intermediate in various chemical processes and research applications.

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Lab products found in correlation

Dimethyl sulfoxide (dmso), by Merck Group (2 mentions) Hplc grade acetonitrile, by Merck Group (2 mentions) Triethylamine, by Merck Group (2 mentions) Hplc grade methanol, by Thermo Fisher Scientific (1 mentions) Bioultra, by Merck Group (1 mentions) Methanol, by Thermo Fisher Scientific (1 mentions) N n diisopropylethylamine, by Merck Group (1 mentions) 1 4 dioxane, by Merck Group (1 mentions) N n dimethylformamide (dmf), by Merck Group (1 mentions) Fmoc l leu oh, by Chem-Impex (1 mentions)

3 protocols using 1 1 1 3 3 3 hexafluoroisopropyl alcohol

Reagent Preparation for HPLC Analysis

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All the reagents were purchased at the highest commercial grade possible and used without any further purification, unless otherwise noted. Acetonitrile (HPLC grade, cat# 34851, Sigma-Aldrich, USA), methanol (HPLC grade, cat# A452SK-4, Fisher Scientific, USA), N,N-dimethyl acetamide (DMA) (HPLC grade, 99.5%, cat# 22916, Alfa Aesar, USA), Dimethyl sulfoxide (DMSO) (≥99.5%, cat# D5879, Sigma-Aldrich, USA), 1,1,1,3,3,3-Hexafluoroisopropyl alcohol (99.9%, cat# 00080, Chem-Impex international, Inc., USA), Triethylamine (≥99%, cat# T0886, Sigma-Aldrich, US). UltraPure distilled water (DNAse, RNAse free, cat# 10977-015, Invitrogen, USA) and sodium hydroxide solution (BioUltra, 10 M in H₂O, cat# 72068, Sigma-Aldrich, USA) were used for buffer preparation. Deionized water was used for LCMS mobile phase preparation.

Sunkari Y.K., Nguyen T.L., Siripuram V.K, & Flajolet M. (2023). Impact of organic chemistry conditions on DNA durability in the context of DNA-encoded library technology. iScience, 26(9), 107573.

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Optimized PEGylation Protocol

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The following commercially available reagents
were used: acetonitrile (HPLC grade, cat# 34851, Sigma-Aldrich, USA),
methanol (HPLC grade, cat# A452SK-4, Fisher Scientific, USA), N,N-dimethyl formamide (DMF) (HPLC grade,
cat# 588725, Sigma-Aldrich, USA), N,N-dimethyl acetamide (DMA) (HPLC grade, 99.5%, cat# 22916, Alfa Aesar,
USA), 1,4-dioxane (HPLC grade, cat# 296309, Sigma-Aldrich, USA), dimethyl
sulfoxide (DMSO) (≥99.5%, cat# D5879, Sigma-Aldrich, USA),
1,1,1,3,3,3-Hexafluoroisopropyl alcohol (99.9%, cat# 00080, Chem-Impex
International, Inc., USA), Triethylamine (≥99%, cat# T0886,
Sigma-Aldrich, USA), and N,N-diisopropylethyl amine
(≥99%, cat# T0886, Sigma-Aldrich, USA). UltraPure distilled
water (DNase, RNase free, cat# 10977-015, Invitrogen, USA) and sodium
hydroxide solution (BioUltra, 10 M in H₂O, cat# 72068,
Sigma-Aldrich, USA) were used for buffer preparation. Deionized water
was used for the LC-MS mobile phase preparation. Activated polyethylene
glycol mPEG-SCM (PEG-NHS ester, molecular weight of PEG ∼5,000)
was purchased from Biopharma PEG Scientific Inc., USA. The other PEG-NHS
esters of different molecular weights (∼1,000; ∼2,000;
∼3,400; ∼10,000; ∼20,000) were also purchased
from Biopharma PEG Scientific Inc., USA.

Siripuram V.K., Sunkari Y.K., Ma F., Nguyen T.L, & Flajolet M. (2024). Reversible and Fully Controllable Generation of Organo-Soluble DNA (osDNA). ACS Omega, 9(13), 14771-14780.

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Synthetic Peptide Preparation and Purification

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H-L-Leu-2-chlorotrityl resin, O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HCTU), Fmoc-L-Dab(ivDde)-OH, Fmoc-L-Dab(Boc)-OH, Fmoc-D-Dab(Boc)-OH, Fmoc-L-Leu-OH and 1,1,1,3,3,3-hexafluoroisopropyl alcohol (HFIP) were purchased from Chem-Impex International Inc. (Wood Dale, IL). 3-(R)-Hydroxydecanoic acid methyl ester was purchased from Toronto Research Chemicals, Inc. (Toronto, Canada).

Han M.L., Shen H.H., Hansford K.A., Schneider E.K., Sivanesan S., K.a.d.e., Roberts D., Thompson P.E., Le Brun A.P., Zhu Y., Sani M.A., Separovic F., Blaskovich M.A., Baker M.A., Moskowitz S.M., Cooper M.A., Li J, & Velkov T. (2017). Investigating the interaction of octapeptin A3 with model bacterial membranes. ACS infectious diseases, 3(8), 606-619.

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