Inveon pet ct machine

Manufactured by Siemens

The Siemens Inveon PET/CT machine is a laboratory instrument designed for small animal imaging. It combines positron emission tomography (PET) and computed tomography (CT) technologies to enable high-resolution, non-invasive imaging of biological processes and anatomical structures in small animals. The Inveon PET/CT machine provides researchers with the ability to acquire both functional and anatomical data from the same subject.

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Crc 15r, by Mirion Technologies (1 mentions)

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4 protocols using inveon pet ct machine

Micro-CT Imaging of Experimental Animals

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One week before euthanasia, all experimental animals underwent micro-computed tomography (CT) imaging using a Siemens Inveon PET/CT machine. The animals were sedated with 5% isoflurane before imaging. Micro-CT imaging produced DICOM (Digital Imaging and Communications in Medicine) image files that were converted to Imaris image file format using Imaris File Converter software. The Imaris images were analyzed using Imaris 3D Analysis software.

Smith M.C., Belur L.R., Karlen A.D., Erlanson O., Furcich J., Lund T.C., Seelig D., Kitto K.F., Fairbanks C.A., Kim K.H., Buss N, & McIvor R.S. (2024). Comparative dose effectiveness of intravenous and intrathecal AAV9.CB7.hIDS, RGX-121, in mucopolysaccharidosis type II mice. Molecular Therapy. Methods & Clinical Development, 32(1), 101201.

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Whole-body imaging for mouse biometrics

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One week before mouse euthanasia, experimental mice were sedated with 5% isoflurane, and whole-body X-ray or Micro-computed tomography (Micro-CT) images were acquired using a Bruker Xtreme or Siemens Inveon PET/CT machine, respectively. The acquired DICOM files were exported from the machines and converted to Imaris image files using the Imaris File Converter software. This conversion resulted in an X-ray or Micro-CT file that could be analyzed using the Imaris 3D Analysis software. Imaris 3D Analysis software was then utilized to obtain body measurements of the X-ray or Micro-CT scans, including zygomatic arch diameter.

Smith M.C., Belur L.R., Karlen A.D., Erlanson O., Podetz-Pedersen K.M., McKenzie J., Detellis J., Gagnidze K., Parsons G., Robinson N., Labarre S., Shah S., Furcich J., Lund T.C., Tsai H.C., McIvor R.S, & Bonner M. (2022). Phenotypic Correction of Murine Mucopolysaccharidosis Type II by Engraftment of Ex Vivo Lentiviral Vector-Transduced Hematopoietic Stem and Progenitor Cells. Human Gene Therapy, 33(23-24), 1279-1292.

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Evaluating CD40-Targeted PET Imaging

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Groups of 5 C57BL/6 mice with mT4 tumors received [⁶⁴Cu]Cu-NOTA-aCD40 or [⁶⁴Cu]Cu-NOTA-IgG (7.4 MBq, 10 μg) via tail vein injection. Mice were anesthetized with 2% isoflurane at room temperature, and whole body radioactivity was measured at 0, 24 and 48 h post injection (p.i.) by placing the mice in a dose calibrator (Capintec CRC 15R). Mice were then placed in the prone position and near the center of the field of view of the PET/CT scanner. Thirty-minute scans were acquired on a Siemens Inveon PET/CT machine at 24 and 48 h p.i. Images were reconstructed using a two-dimensional ordered-subset expectation maximization (OSEM 2D) algorithm. At 48 h p.i. biodistribution studies were performed to compare tumor and normal tissue uptake of [⁶⁴Cu]Cu-NOTA-aCD40 and [⁶⁴Cu]Cu-NOTA-IgG. Following imaging, mice were sacrificed by cervical dislocation under anesthesia. Tissues of interest were collected, counted using a γ-counter, weighted and the results were reported as % ID/g.

Aghevlian S., Wu B., Raie M.N., Tumble S.K., Kare A.J., Seo J.W, & Ferrara K.W. (2021). Pre-clinical evaluation of immunoPET imaging using agonist CD40 monoclonal antibody in pancreatic tumor-bearing mice. Nuclear medicine and biology, 98-99, 8-17.

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Micro-CT Imaging and Body Measurements

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Test animals were sedated with 5% isoflurane and whole-body micro-computed tomography (CT) images captured using a Siemens Inveon PET/CT machine. The acquired DICOM files were exported and converted to Imaris image files using Imaris File Converter software. Imaris 3D Analysis software was then utilized to obtain body measurements of the micro-CT scans, including zygomatic arch diameter (midpoint), snout length, femur length and midpoint femur diameter.

Smith M.C., Belur L.R., Karlen A.D., Podetz-Pedersen K., Erlanson O., Laoharawee K., Furcich J., Lund T.C., You Y., Seelig D., Webber B.R, & McIvor R.S. (2023). Generation and characterization of an immunodeficient mouse model of mucopolysaccharidosis type II. Molecular genetics and metabolism, 138(4), 107539.

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