Hiv combi

Manufactured by Roche

Sourced in Germany

The HIV Combi is a laboratory equipment product designed for the detection and quantification of HIV-1 and HIV-2 infections. It provides a reliable and accurate method for the diagnosis of HIV status.

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Lab products found in correlation

Cobas e, by Roche (1 mentions) Determine hiv 1 2, by Abbott (1 mentions) Eclia, by Roche (1 mentions)

Spelling variants of this product

Elecsys HIV combi PT (5 citations) Roche Elecys 2010 HIV Combi (4 citations) HIV 1/2 Combi Roche Elecsys (2 citations)

4 protocols using hiv combi

Sudden Death Autopsy HIV Screening

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Blood samples were obtained from decedents who died suddenly and/or unexpectedly. This was done during autopsy, by a forensic pathologist. Sample collection continued until 100 valid samples were analysed. A study and funding limitation was that only 100 samples were to be collected.
The processing of blood samples was done by the following standardised testing procedures developed and used in the NHLS Tshwane virology research department:

After centrifugation of whole blood, the serum was used to run the test in order to minimise the effect that haemolysed blood has on test strips.

The screening test used was the Determine™ HIV-1/2 Ag/Ab Combo assay, and the confirmatory test used was the HIV Combi, Cobas E, Elecsys and Modular (Roche).^{18 (link)}

Morris N.K., du Toit-Prinsloo L., Webber L, & Saayman G. (2016). The prevalence of HIV in the sudden, unexplained and unexpected death population at the Pretoria Medico-Legal Laboratory. Southern African Journal of HIV Medicine, 17(1), 424.

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Retrospective TBM Severity Grading

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Patients were retrospectively scored according to the British Medical Research Council TBM severity grade (British Medical Research Council, 1948 (link)) and classified according to consensus uniform research case definition criteria (Marais et al., 2010 (link)), as “definite”, “probable,” or “possible” TBM (Table 1). Since the study aimed to evaluate the diagnostic performance of MZN, MZN was not included in the classification. The “not TBM” category was sub-divided into cases of infectious neurological disorders (IND) and non-infectious neurological disorders (NIND). All patients were tested for HIV (Roche Elecsys HIV Combi, Basel, Switzerland). Additional information was gathered from reviewing relevant clinical notes. Patients were excluded if their clinical data were incomplete or consent for participation was not obtained.

Wang T., Feng G.D., Pang Y., Yang Y.N., Dai W., Zhang L., Zhou L.F., Yang J.L., Zhan L.P., Marais B.J., Zhao Y.L, & Zhao G. (2016). Sub-optimal Specificity of Modified Ziehl-Neelsen Staining for Quick Identification of Tuberculous Meningitis. Frontiers in Microbiology, 7, 2096.

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Antenatal HIV Diagnosis Workflow

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HIV diagnosis was assessed at the woman’s first antenatal visit. A participant provided a blood specimen from a finger prick for a rapid HIV test (Determine: Abbott Laboratories, Abbott Park, IL). If a reactive result was obtained with the Determine rapid HIV test, the participant’s HIV status was confirmed with a second rapid test (SmartCheck HIV 1&2, World Diagnostic Inc., Miami Lakes, FL, USA). In instances where a specimen was reactive to the Abbott kit, but negative on the SmartCheck, a blood specimen was sent for confirmation by a 4^th generation ELISA (HIV Combi, Roche Mannheim, Germany) performed at the Department of Virology, University of KwaZulu-Natal.

Groves A.K., Reyes H.L., Moodley D, & Maman S. (2018). HIV positive diagnosis during pregnancy increases risk of IPV postpartum among women with no history of IPV in their relationship. AIDS and behavior, 22(6), 1750-1757.

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Comprehensive Viral Serology Screening

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Blood samples were taken for serological testing on HIV, hepatitis B virus (HBV), hepatitis C virus (HCV) and measurement of the CD4 cell-count per ml blood. HIV antibodies were measured using commercially available rapid tests (Determine HIV-1/2, Abbott laboratories, Tokyo, Japan; SD HIV-1/2 3.0, Standard Diagnostic, Inc, Kyonggi-do, Korea); enzyme immunoassay (EIA; Virolisa, Index Union Diagnostic, Korea); and electrochemiluminescence immunoassay (ECLIA; HIV combi, Roche, Mannheim, Germany) in accordance with national guidelines. HBsAg, anti-HBs, anti-HBc and anti-HCV were measured by ECLIA (Roche diagnostic, Mannheim, Germany). External quality control of HIV, HBV and HCV serology (National Serology Reference Laboratory, Australia) showed 100 % accuracy. CD4 cell measurements were taken using Facscount flow cytometry technology (BD Biosciences, Jakarta, Indonesia). External quality assurance for CD4 measurement was performed from COE Thailand and Qasi Canada (SD < 1 %).

Rahmalia A., Wisaksana R., Meijerink H., Indrati A.R., Alisjahbana B., Roeleveld N., van der Ven A.J., Laga M, & van Crevel R. (2015). Women with HIV in Indonesia: are they bridging a concentrated epidemic to the wider community?. BMC Research Notes, 8, 757.

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