Chlorzoxazone czx

Manufactured by Merck Group

Sourced in United States, France

Chlorzoxazone (CZX) is a muscle relaxant compound used in laboratory research settings. It functions as a centrally-acting skeletal muscle relaxant. The core purpose of CZX is to reduce skeletal muscle spasms and tone.

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Chlorzoxazone (70 citations)

2 protocols using chlorzoxazone czx

Bicyclol Efficacy and Mechanism Study

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Bicyclol was kindly provided by the Beijing Union Pharmaceutical Plant (purity >99%). RIF and PZA were the products of J&K Scientific Ltd. (Beijing, China). INH, Rhodamine 123, palmitoyl-CoA, oxaloacetate, adenosine diphosphate (ADP), rotenone, antimycin A, ubiquinone-1, chlorzoxazone (CZX), 6-hydroxyl-chlorzoxazone (6-OH-CZX), arachidonic acid, cytochrome c, reduced nicotinamide adenine dinucleotide (NADH), glucose 6-phosphate, β-NADP, glucose 6-phosphate dehydrogenase, phenacetin, resveratrol, and nicotinamide adenine dinucleotide (NAD) were purchased from Sigma Chemical Co. (St Louis, MO, USA). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) assay kits were obtained from BHKT Chemical Reagent Co., Ltd. (Beijing, China). TBIL, MDA, AKP, SOD, GSH, CAT and GSH-Px kits were purchased from Nanjing Jiancheng Bioengineering Institute (Nanjing, China). Enzyme-linked immunosorbent assay (ELISA) kits were products from eBioscience (San Diego, CA, USA). Other chemicals were of analytical grade and were obtained from the local market.

Liu X., Zhao M., Mi J., Chen H., Sheng L, & Li Y. (2017). Protective Effect of Bicyclol on Anti-Tuberculosis Drug Induced Liver Injury in Rats. Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 22(4), 524.

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Liver Cell Culture Reagents

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5-Aminoimidazole-4-carboxyamide ribonucleoside (AICAR), APAP, APAP-β-D-glucuronide, APAP-sulfate, testosterone, 6β-hydroxytestosterone, chlormethiazole (CMZ), chlorzoxazone (CZX), metformin, dimethyl sulfoxide (DMSO), oleic acid, stearic acid, insulin and oil Red O were purchased from Sigma Aldrich (Saint-Quentin-Fallavier, France). William’s E medium was obtained from Eurobio laboratories (Les Ulis, France). Fetal Bovine Serum (FBS) was supplied by Lonza (Levallois-Perret, France). Glutamine, penicillin and streptomycin were obtained from Invitrogen (Cergy Pontoise, France). Hydrocortisone hemisuccinate was purchased from Upjohn Pharmacia (Guancourt, France). Protease and phosphatase inhibitors were purchased from Roche Diagnostics (Indianapolis, IN).

Michaut A., Le Guillou D., Moreau C., Bucher S., McGill M.R., Martinais S., Gicquel T., Morel I., Robin M.A., Jaeschke H, & Fromenty B. (2015). A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen. Toxicology and applied pharmacology, 292, 40-55.

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