Kk hij

Manufactured by Jackson ImmunoResearch

Sourced in United States

KK/HIJ is a laboratory instrument used for the detection and analysis of specific proteins or molecules. It utilizes a combination of specialized techniques to identify and quantify the target analytes. The core function of KK/HIJ is to provide researchers with reliable and accurate data, enabling them to further their scientific investigations.

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Lab products found in correlation

3 protocols using kk hij

Mouse Strains for PTR Studies

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The PTR studies in mice were performed as described previously,^{34 (link)} using multiple strains from Jackson Labs (Bar Harbor, ME, USA): KK/HIJ, LG/J, AKR/J, FVB/NJ, C3H/HeJ, DBA/2J, NOD/ShiLtJ, 129X1/SvJ, 129S1/SvImJ, A/J, BTBR/T+ tf/J, Balb/cByJ, C57Bl/6J. UbiC-GFP male mice, on a C57BL/6 background, were bred to FVB/NJ females in the Bloodworks NW Research Institute Vivarium (Seattle, WA, USA) and offspring were used as transfusion recipients at 24–28 weeks of age.^{34 (link)}

Nemkov T., Sun K., Reisz J.A., Song A., Yoshida T., Dunham A., Wither M.J., Francis R.O., Roach R.C., Dzieciatkowska M., Rogers S.C., Doctor A., Kriebardis A., Antonelou M., Papassideri I., Young C.T., Thomas T.A., Hansen K.C., Spitalnik S.L., Xia Y., Zimring J.C., Hod E.A, & D’Alessandro A. (2018). Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage. Haematologica, 103(2), 361-372.

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Mouse Diversity Panel Protocol

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Thirty-six male inbred mouse strains (129S1/SvImJ, 129X1/SvJ, A/J, AKR/J, BALB/cByJ, BTBR T⁺Itpr3^tf/J, BUB/BnJ, C3H/HeJ, C57BLKS/J, C57BL/6J, C57BR/cdJ, C58/J, CBA/J, CZECHII/EiJ, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LG/J, LP/J, MA/MyJ, NOD/LtJ, NON/LtJ, NZB/BINJ, NZO/HiLtJ, NZW/LacJ, PERA/EiJ, PL/J, PWD/PhJ, PWK/PhJ, RIIIS/J, SEA/GnJ, SJL/J, SM/J, SWR/J, and WSB/EiJ), aged 10–12 weeks, were obtained from The Jackson Laboratory (Bar Harbor, ME, USA). This panel of isogenic mice was chosen based on priority strains from the Mouse Diversity Panel.26 (link) Four mice were used per strain. Male mice were housed four per cage in polycarbonate cages on a 12-hour light/dark cycle (lights on at 7 am), with access to food and water ad libitum. All procedures were approved by the Institutional Animal Care and Use Committee and followed the guidelines set forth by the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals.

Frick A., Fedoriw Y., Richards K., Damania B., Parks B., Suzuki O., Benton C.S., Chan E., Thomas R.S, & Wiltshire T. (2015). Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics. Pharmacogenomics and Personalized Medicine, 8, 81-98.

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Inbred Mouse Strains for Experiments

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Mice of inbred strains A/J, AKR/J, C3H/HeJ, C57BL/6J, 129S1/SvImJ, and KK/HIJ, and B6.129S7-Ifngtm1Ts/J mice were purchased from the Jackson Laboratory (Bar Harbor, USA) and housed in the Meakins-Christie Laboratories. Mice of other strains, on the C57BL/6J background, were obtained through collaboration (Tlr2,4−/− mice from Dr. Qureshi of McGill University) or a material transfer agreement (interleukin-17 (Il17)−/− mice from Dr. Iwakura of the University of Tokyo, ref. 56 (link)) and experimental mice bred in house. All mice were handled according to guidelines and regulations of the Canadian Council on Animal Care. Specifically, the animal experiments were performed in accordance with protocol 5601 approved by the Animal Care Committee of the Research Institute of the McGill University Health Centre.

Paun A., Bergeron M.E, & Haston C.K. (2017). The Th1/Th17 balance dictates the fibrosis response in murine radiation-induced lung disease. Scientific Reports, 7, 11586.

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