Rad51 inhibitor b02

Manufactured by MedChemExpress

Sourced in United States

RAD51 Inhibitor B02 is a small molecule that inhibits the activity of the RAD51 protein, which is involved in DNA double-strand break repair. This compound can be used in research applications to study the role of RAD51 in cellular processes.

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Lab products found in correlation

Niraparib, by Selleck Chemicals (1 mentions) Rucaparib, by Selleck Chemicals (1 mentions) Cisplatin, by Apexbio (1 mentions) Carboplatin, by Apexbio (1 mentions) Olaparib, by Apexbio (1 mentions) Veliparib abt 888, by Selleck Chemicals (1 mentions) 5 fluorouracil, by Apexbio (1 mentions) Nms p118, by Selleck Chemicals (1 mentions) Cisplatin, by Adooq (1 mentions) Art558, by MedChemExpress (1 mentions) Nedisertib, by MedChemExpress (1 mentions) Azd7648, by MedChemExpress (1 mentions) Olaparib, by MedChemExpress (1 mentions) Superscript 3 enzyme, by Thermo Fisher Scientific (1 mentions) Berberine, by Merck Group (1 mentions) Mtt kit, by Merck Group (1 mentions) E cadherin, by Cell Signaling Technology (1 mentions) Vimentin, by Cell Signaling Technology (1 mentions)

2 protocols using rad51 inhibitor b02

Comprehensive Synthetic Compound Library

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Olaparib (Catalog# A4154), cisplatin (Catalog# A8321), carboplatin (Catalog# A2171), and 5-fluorouracil (Catalog# A4071) were all purchased from APExBIO company. UPF 1096 (Catalog# S8038), NMS-P118(Catalog# S8363), stenoparib (E7449) (Catalog# S8419), niraparib (Catalog# S2741), rucaparib (Catalog# S4948), and veliparib (ABT-888) (Catalog# S1004) were all purchased from Selleckchem.
cisplatin (Catalog# A10221) was purchased from AdooQ Bioscience. ART-558(Catalog# HY-141520), DNA-PK inhibitors PIK-75 hydrochloride (Catalog# HY-13281), Nedisertib (Catalog# HY-101570) and AZD-7648 (Catalog# HY-111783), RAD51 Inhibitor B02 (Catalog# HY-101462), and Olaparib (for in vivo experiment: Catalog# HY-10162) were all purchased from MCE (MedChem Express). ART-812 was synthetized by Dr. Wayne Childers at Temple University School of Pharmacy. All compounds were dissolved, aliquoted, and stored following the manufacturer’s instructions.

Li H., Chatla S., Liu X., Vekariya U., Kim D., Walt M., Lian Z., Morton G., Feng Z., Yang D., Liu H., Reed K., Childers W., Yu X., Madzo J., Chitrala K.N., Skorski T, & Huang J. (2023). Haploinsufficiency of ZNF251 causes DNA-PKcs-dependent resistance to PARP inhibitors in BRCA1-mutated cancer cells. Research Square.

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Berberine-Induced Rad51 Inhibition

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Berberine was purchased from Sigma-Aldrich Chemical Corp (St. Louis, MO, USA). The MTT kit was purchased from Sigma Chemical Co. (St. Louis, MO, USA). Reverse transcriptase was purchased from Superscript III enzyme (Life Technologies, USA). The quantitative reverse transcription-polymerase chain reaction (qRT-PCR) kit was purchased from SYBR Green reagent (TaKaRa, Japan). Antibodies were purchased from the following sources: mouse monoclonal antibodies against human Rad51, E-cadherin, and vimentin were purchased from Cell Signaling Technology (Danvers, MA, USA). Rad51 inhibitor B02 was purchased from MedChem Express (No. HY-101462, New Jersey, USA).

Wang D., Zhang K.F., Du G., Wang J, & Zhao J. (2020). Berberine enhances the radiosensitivity of osteosarcoma by targeting Rad51 and epithelial-mesenchymal transition. Journal of cancer research and therapeutics, 16(2).

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