Angii powder

Manufactured by Bachem

AngII powder is a synthetic peptide product manufactured by Bachem. It is a white to off-white powder. The core function of AngII powder is to serve as a research tool for in vitro and in vivo studies.

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Lab products found in correlation

Alzet model 2004, by Durect (2 mentions)

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AngII (56 citations)

2 protocols using angii powder

Angiotensin II-Induced Aortic Aneurysm

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We used a second AAA model [12 (link)] in which continuous angiotensin II (AngII) infusion in apolipoprotein-E-deficient (apoE^−/−) mice induces suprarenal AAA formation typically between 3 and 14 days after implantation of miniosmotic pumps (ALZET Model 2004; DURECT Corporation, Cupertino, CA). AngII powder (MW: 1046.19; Bachem, Torrance, CA) was solubilized in 0.9% sodium chloride and loaded into miniosmotic pumps for systemic hormone delivery (1000 ng/kg/min infusion rate and 28-day duration) following subcutaneous implantation in the dorsum of mice (n = 7).

Phillips E.H., Yrineo A.A., Schroeder H.D., Wilson K.E., Cheng J.X, & Goergen C.J. (2015). Morphological and Biomechanical Differences in the Elastase and AngII apoE −/− Rodent Models of Abdominal Aortic Aneurysms. BioMed Research International, 2015, 413189.

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Chronic AngII Infusion in Rats

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We implanted an AngII mini-osmotic pump (ALZET Model 2004; DURECT Corporation, Cupertino CA) subcutaneously in the left dorsum of each rat. AngII powder (MW: 1046.19; Bachem, Torrance CA) was first solubilized in sterile 0.9% saline and loaded into the pumps according to animal weight (200 ng/kg/min infusion rate [21 (link)] for 28-day duration). To prime the pumps, we incubated them in sterile saline at 37°C overnight before implantation. We performed the same procedure to implant a second pump in the rats in Cohorts 1b and 2b. The first expired pump remained in the rat and the new pump was placed on the opposite side of the animal. No apoE^−/− rats were implanted with saline-filled pumps to serve as a control.

Phillips E.H., Chang M.S., Gorman S., Qureshi H.J., Ejendal K.F., Kinzer-Ursem T.L., Blaize A.N, & Goergen C.J. (2017). Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats. Journal of vascular research, 55(1), 1-12.

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