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2 protocols using ciprofloxacin base

1

Ciprofloxacin-Loaded Mucoadhesive Nanocarriers

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Ciprofloxacin base (molecular weight: 331.34 Da), hyaluronic acid (LMW HA, MW 500 kDa), N-hydroxy succinimide (NHS), 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDAC),cremophore RH 40, tween 80, PEG 400, PEG 200, artificial mucin, oleic oil, linseed oil, caproyl 90, labrafil M, mineral oil, dulbecco’s modified eagle’s medium (DMEM), rhodamine, crystal violet, congo red, 4′,6-diamidino-2-phenylindole(DAPI), and fluorescein isothiocyanate (FITC) dye were purchased from Sigma Aldrich, Germany. Cystamine dihydrochloride was purchased from Avonchem, New Hampshire, UK) United Kingdom. All solvents used were of analytical grade.
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2

Ciprofloxacin Formulation Optimization

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Materials: Ciprofloxacin base, ciprofloxacin hydrochloride monohydrate, succinic acid, glutaric acid, adipic acid and pimelic acid were obtained from Sigma-Aldrich (Dorset, UK). Methanol was obtained from Fisher-Scientific Limited (Leicestershire, UK). All chemicals were used as received.
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