Pcp hcl

Manufactured by Merck Group

Sourced in United Kingdom

PCP HCl is a laboratory chemical compound. It is the hydrochloride salt of phencyclidine, a dissociative anesthetic. This product is intended for use in scientific research, analysis, and other laboratory applications. No further details on intended use can be provided.

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Lab products found in correlation

Ondansetron, by Bio-Techne (1 mentions) Sb399885, by Bio-Techne (1 mentions) Clozapine, by Abcam (1 mentions) Dopamine, by Merck Group (1 mentions) L glutamate, by Merck Group (1 mentions) Ascorbic acid, by Merck Group (1 mentions) L cysteine, by Merck Group (1 mentions)

2 protocols using pcp hcl

Clozapine and Pharmacological Treatments

Cited 1 time

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Clozapine (Abcam Biochemicals,
Cambridge, U.K.)
was dissolved in 0.1 N HCl supplemented with distilled water to the
appropriate volume (final pH = 5.0–6.0). PCP HCl (Sigma-Aldrich),
ondansetron (Tocris, U.K.), SB399885 (Tocris, U.K.), FPPQ, and CPPQ ((S)-1-[(3-chlorophenyl)sulfonyl]-4-(pyrrolidine-3-yl-amino)-1H-pyrrolo[3,2-c]quinolone)^{29 (link),67 (link)} were dissolved
in distilled water. All compounds were administrated in a volume of
1 mL/kg.

Zajdel P., Grychowska K., Mogilski S., Kurczab R., Satała G., Bugno R., Kos T., Gołębiowska J., Malikowska-Racia N., Nikiforuk A., Chaumont-Dubel S., Bantreil X., Pawłowski M., Martinez J., Subra G., Lamaty F., Marin P., Bojarski A.J, & Popik P. (2021). Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties. Journal of Medicinal Chemistry, 64(18), 13279-13298.

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Neurotransmitter Assay Protocols

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PCP HCl, L-glutamate, 5-HT, dopamine, ascorbic acid, and L-cysteine were purchased from Sigma-Aldrich, α-latrotoxin from Enzo Life Sciences (Exeter, UK), and all other compounds from Tocris (Bristol, UK). For microsensor studies, stock solutions of TBOA, SB-399885, CPPG, MMPIP, TTX (2–10 mM in saline), and α-latrotoxin (300 nM in 50% glycerol) were stored in aliquots at − 20 °C and diluted in aCSF on the day of use. All other solutions were prepared daily.

Shortall S.E., Brown A.M., Newton-Mann E., Dawe-Lane E., Evans C., Fowler M, & King M.V. (2020). Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia. Molecular Neurobiology, 57(8), 3439-3457.

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