NOD/LtDvs (hereafter NOD) mice are maintained at the Medical College of Wisconsin (MCW) by brother-sister mating. ICR/HaJ (ICR), NOD.Cd45.2, and NOD.Cd1d−/− mice were purchased from The Jackson Laboratory (TJL) (stock numbers 009122, 014149, and 006330 respectively) and maintained by brother-sister mating at the MCW. Five-week-old male NOD/ShiLtJ, CBA/J, BALB/cJ, 129/SvInJ, A/J, FVB/J, SJL/J, C57BL6/J, and DBA2/J were purchased from TJL and housed in the MCW vivarium for two weeks before the experiments. NOD mice were outcrossed to ICR mice to generate reciprocal F1 females that were subsequently mated to NOD males to generate first backcross (BC1) progeny. A total of 163 male BC1 mice were generated for analysis. Results from all BC1 males derived from both directions of the F1 crosses were combined for statistical analyses. All BC1 mice were analyzed at 7 weeks old. Previous studies showed sex difference in the frequency of thymic iNKT-cells10 (link). Based on this reason, male mice were used in all analyses. All animal protocols were approved by the MCW Institutional Animal Care and Use Committees.
Nod cd1d mice
Manufactured by Jackson ImmunoResearch
NOD.Cd1d−/− mice are a genetically modified mouse strain that lacks the Cd1d gene. The Cd1d gene is involved in the development and function of natural killer T (NKT) cells. These mice are commonly used in immunological research to study the role of NKT cells in various biological processes.
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2 protocols using nod cd1d mice
1
Analyzing iNKT Cells in NOD Mice
2
Analyzing iNKT Cells in NOD Mice
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NOD/LtDvs (hereafter NOD) mice are maintained at the Medical College of Wisconsin (MCW) by brother-sister mating. ICR/HaJ (ICR), NOD.Cd45.2, and NOD.Cd1d−/− mice were purchased from The Jackson Laboratory (TJL) (stock numbers 009122, 014149, and 006330 respectively) and maintained by brother-sister mating at the MCW. Five-week-old male NOD/ShiLtJ, CBA/J, BALB/cJ, 129/SvInJ, A/J, FVB/J, SJL/J, C57BL6/J, and DBA2/J were purchased from TJL and housed in the MCW vivarium for two weeks before the experiments. NOD mice were outcrossed to ICR mice to generate reciprocal F1 females that were subsequently mated to NOD males to generate first backcross (BC1) progeny. A total of 163 male BC1 mice were generated for analysis. Results from all BC1 males derived from both directions of the F1 crosses were combined for statistical analyses. All BC1 mice were analyzed at 7 weeks old. Previous studies showed sex difference in the frequency of thymic iNKT-cells10 (link). Based on this reason, male mice were used in all analyses. All animal protocols were approved by the MCW Institutional Animal Care and Use Committees.
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