In the a-TACE group, conventional TACE was performed 4–6 weeks after surgery based on the patient’s liver function and performance status, and the specific steps were implemented according to the previously described technique.24 (link) In brief, a catheter was inserted into the hepatic artery through the femoral artery using Seldinger technique for hepatic artery angiography, and 200 mg/m2 Carboplatin (Carboplatin, Bristol-Myers Squibb, New York, NY, USA) and 6 mg/m2 mitomycin (Mitomycin, Hisun, Taizhou, China) were administered followed by injection of 4–5 mL of iodized oil emulsion (lipiodol, Andre Guerbet, Aulnay-sous-Bois, France) and 40 mg/m2 epirubicin hydrochloride (epirubicin hydrochloride, Pfizer, New York, NY, USA). These patients underwent comprehensive evaluation including physical examination, routine blood analysis and CT scan approximately one month later. The second cycle of TACE or HAIC was performed according to the decision of investigators based on the patients’ conditions and the assessment results.
Epirubicin hydrochloride
Manufactured by Pfizer
Sourced in United States
Epirubicin hydrochloride is a cytotoxic anthracycline antibiotic. It is used as a chemotherapeutic agent.
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3 protocols using epirubicin hydrochloride
1
TACE Protocol for Hepatocellular Carcinoma
2
Cytotoxicity Evaluation of Anticancer Drugs
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Clinical-grade (NCI Dictionary of Cancer Terms, http://www.cancer.gov/dictionary ), pirarubicin (Pi, Wanle, Shenzhen) paclitaxel (Pa, Taiji, Sichuan), Adriamycin (Ad, Pfizer, Jiangsu), epirubicin hydrochloride (EH, Haizheng, Zhejiang), and cisplatin (Ci, Haosen, Jiangsu) were used. Relative IC50 values were determined as previously described [21 (link)].
3
TACE after Hepatectomy for Liver Cancer
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The patients in the Hepatectomy-TACE group underwent TACE 4–6 weeks after hepatectomy according to liver function and performance status. TACE was performed using the techniques we have described previously [24 (link)]. In brief, a catheter was placed into the proper hepatic artery through the femoral artery using the Seldinger technique, hepatic arterial angiography was performed, and 200 mg/m2 Carboplatin (Carboplatin, Bristol-Myers Squibb, New York, NY, USA) and 6 mg/m2 mitomycin (Mitomycin, Hisun, Taizhou, China) were infused followed by 4–5 mL of the emulsion of iodized oil (lipiodol, Andre Guerbet, Aulnay-sous-Bois, France) and 40 mg/m2 epirubicin (Epirubicin Hydrochloride, Pfizer, New York, NY, USA). After 4–6 weeks, these patients underwent a complete assessment consisting of physical examination, routine blood analysis, and CT scan. The second cycle of TACE was performed according to the decision of investigators based on the patients’ conditions and the assessment results.
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