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Propofol 1 mct lct

Manufactured by Fresenius
Sourced in Germany, Greece

Propofol 1% MCT/LCT Fresenius is a clear, colorless, sterile, non-pyrogenic injectable emulsion containing 10 mg of propofol per milliliter. It is a short-acting intravenous anesthetic agent used for the induction and maintenance of general anesthesia. The product is formulated with medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) as the lipid components.

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4 protocols using propofol 1 mct lct

1

Anesthesia and Fluid Management in Surgery

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During the surgery, sedation using IV propofol (Propofol 1% MCT/LCT Fresenius, Fresenius Kabi, Bad Homburg, Germany) at 25–50 µg/kg/min or headphones connected to an audio system (relaxing music) were used on patient’s request [18 (link),19 ]. Standard intraoperative fluid therapy using balanced crystalloids at a dose of 1–2 mL/kg/h was used. In the event of bradycardia (HR < 50 bpm or a decrease >20% of the baseline value), IV atropine (Atropine Sulfuricum, Polfa Warszawa, Poland) was administered in fractionated doses of 0.01 mg/kg of body weight up to a maximum dose of 2 mg. In the case of mean blood pressure drop below 70 mmHg or >25% vs. baseline, IV ephedrine (Ephedrinum Hydrochloricum WZF, Polfa Warszawa, Warsaw, Poland) in fractionated doses of 5 mg (maximum dose 25 mg) or (if ineffective) noradrenaline infusion (Levonor, Polfa Warszawa, Warsaw, Poland) in a syringe pump, titrated to maintain blood pressure >70 mmHg, was used.
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2

Infusion of ABP-700 and Propofol

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ABP-700 was administered as a continuous i.v. infusion over 30 min as a sterile solution containing ABP-700 10 mg ml À1 and 10% sulfobutylether-b-cyclodextrin with meglumine, an amino sugar derived from glucose, used as an excipient, in a 20 ml USP Type I clear glass vial closed with a grey 20 mm butyl Flurotec ® (West Pharmaceutical Services, Exton, PA, USA) coated rubber stopper and sealed with a 20 mm aluminium overseal. Matching placebo contained the same inactive components as ABP-700 in the same type vials as ABP-700. Propofol was supplied as a 1% sterile emulsion for i.v. injection (Propofol 1% MCT/LCT 'Fresenius', Fresenius Kabi, Bad Homburg, Germany). Fentanyl (Fentanyl-hameln, Hameln Pharmaceuticals, Hameln, Germany) was supplied as an aqueous solution.
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3

Anesthetic protocol for feline surgery

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The cats were premedicated with dexmedetomidine (20 μg/kg, intramuscularly [IM], Dexdomitor 0.5 mg/mL; Elanco, Greece) and butorphanol (0.3 mg/kg, IM, Dolorex 10 mg/mL; MSD, Greece). Anesthesia was induced with propofol 1% (2–4 mg/kg, intravenously [IV], Propofol MCT/LCT 1%; Fresenius Kabi Hellas, Greece) and maintained with isoflurane (2%, Isoflo; Abbott Laboratories, UK) in oxygen (2 L/min). An NS 0.9% solution IV was administered at 4 mL/kg/h during anesthesia. Preoperatively, amoxicillin and clavulanic acid (20 mg/kg, subcutaneously [SC], Synulox RTU Inj. 100 mL; Zoetis, Greece) and carprofen (2 mg/kg, IV, Rimadyl; Zoetis) were administered.
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4

Anesthetic Regimen for Feline Procedure

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Cats were premedicated with dexmedetomidine (20 μg/kg, intramuscularly [IM], Dexdomitor 0.5 mg/mL; Elanco, Greece) and butorphanol (0.3 mg/kg, IM, Dolorex, 10 mg/mL; MSD, Netherlands). Anesthesia was induced with 1% propofol (2–4 mg/kg, intravenously [IV], Propofol-MCT/LCT 1%; Fresenius Kabi Hellas, Greece) and maintained with isoflurane (1∼2%, Isoflo; Abbott Laboratories, UK) in oxygen (2 L/min). A 0.9% sodium chloride solution (NS 0.9%) IV was administered at 4 mL/kg/h during anesthesia. Preoperatively, amoxycillin, clavulanic acid (20 mg/kg, subcutaneously [SC], Synulox RTU Inj. 100 mL; Zoetis, Greece) and carprofen (2 mg/kg, IV, Rimadyl; Zoetis, Greece) were administered.
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