The average interval between baseline imaging and infusion was four months (range 0.4 to 11.5 months). Follow-up imaging was performed on average 11.9 months (range 11 to 13 months) after infusion [23 (link)]. The MRI equipment of the baseline imaging included five 1.5 T units (GE Signa Twinspeed, General Electric Medical Systems, Milwaukee, WI, USA; Philips Achieva and Philips Intera, Philips Medical Systems, Eindhoven, The Netherlands; Siemens Avanto and Siemens Espree, Siemens Medical, Erlangen, Germany), a 0.34 T unit (Siemens Magnetom C, Siemens Medical, Erlangen, Germany) and a 0.23 T unit (Philips Panorama, Philips Medical Systems, Eindhoven, The Netherlands). The imaging sequences were sagittal T1-weighted (T1 W) turbo spin-echo (TSE) or fast spin-echo (FSE) with fluid attenuation inversion recovery (FLAIR), sagittal T2-weighted (T2 W) TSE/FSE, and short tau inversion recovery sequences (STIR). The specific imaging parameters have been described previously [23 (link)]. The MRI equipment of the one-year follow-up imaging included two 1.5 T units (GE Signa Twinspeed and GE Optima, General Electric Medical Systems, Milwaukee, WI, USA) and a 3 T unit (Siemens Skyra, Siemens Medical, Erlangen, Germany). Imaging protocols were established for clinical spine imaging.
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