Amoxicillin, atropine, carbamazepine, dicloxacillin, digoxin, erythromycin, estradiol, furosemide, halothane, streptomycin, ticlopidine and lipopolysaccharide (LPS) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Allopurinol, azathioprine, diclofenac, diphenhydramine, flutamide, ibuprofen, imipramine, indomethacin, isoniazid, kanamycin, ketoconazole, metronidazole, nifedipine, phenobarbital, phenytoin, pioglitazone, sulfamethoxazole, troglitazone and valproic acid were purchased from Wako Pure Chemical (Osaka, Japan). Primidone was purchased from the Tokyo Chemical Industry (Tokyo, Japan). Primers were commercially synthesized at Life Technologies (Carlsbad, CA, USA). HaCaT cells were purchased from CLS Cell Lines Service (Eppelheim, Germany). CnT-Prime (CnT-PR) Epithelial Culture Medium and CnT-Prime 2D Diff (CnT-PR-D) Epithelial Culture Medium were from CELLnTEC Advanced Systems (Bern, Switzerland). All other chemicals and solvents were of analytical grade or the highest grade commercially available.
Imipramine
Manufactured by Fujifilm
Sourced in Japan
Imipramine is a laboratory instrument used for the analysis and detection of chemical compounds. It is a versatile tool that can be utilized in various research and testing applications. The core function of Imipramine is to provide accurate and reliable measurements of the target analytes, enabling researchers and scientists to obtain valuable insights into the composition and characteristics of the samples under investigation.
Automatically generated - may contain errors
Lab products found in correlation
Digoxin, by Merck Group (1 mentions)
Erythromycin, by Merck Group (1 mentions)
Carbamazepine, by Merck Group (1 mentions)
Lipopolysaccharide, by Merck Group (1 mentions)
Ticlopidine, by Merck Group (1 mentions)
Kanamycin, by Fujifilm (1 mentions)
Flutamide, by Fujifilm (1 mentions)
Phenobarbital, by Fujifilm (1 mentions)
Streptomycin, by Merck Group (1 mentions)
Estradiol, by Merck Group (1 mentions)
Amoxicillin, by Merck Group (1 mentions)
Furosemide, by Merck Group (1 mentions)
Dicloxacillin, by Merck Group (1 mentions)
Allopurinol, by Fujifilm (1 mentions)
Azathioprine, by Fujifilm (1 mentions)
Diclofenac, by Fujifilm (1 mentions)
Diphenhydramine, by Fujifilm (1 mentions)
Indomethacin, by Fujifilm (1 mentions)
Isoniazid, by Fujifilm (1 mentions)
Ketoconazole, by Fujifilm (1 mentions)
6 protocols using imipramine
1
Comprehensive Pharmacological Compound Database
2
Adrenergic Receptor Antibody Sourcing
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Imipramine and other chemicals were obtained from Wako Pure Chemical Industries (Osaka, Japan), unless otherwise described. Pentobarbital was obtained from Kyoritsu Seiyaku (Tokyo, Japan). Protease inhibitor cocktail and anti-β-actin antibody (A5441) were obtained from Sigma-Aldrich (St. Louis, MO, USA). Anti-α2-adrenergic receptor antibody (sc-28983) was obtained from Santa Cruz Biotechnology (Dallas, TX, USA). Anti-α1-adrenergic receptor antibody (ab137123), anti-rabbit immunoglobulin G (IgG) horseradish peroxidase-conjugated secondary antibody (ab97051), and anti-mouse IgG horseradish peroxidase-conjugated secondary antibody (ab79023) were obtained from Abcam (Cambridge, MA, USA).
3
Chronic Corticosterone Exposure in Mice
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Five-week-old male C57BL6 mice were used for chronic oral CORT exposure. Mice were divided into 5 groups: control group (n = 10), CORT-treated group (n = 10), CORT + NYT (500 or 1000 mg/kg)-treated group (n = 10), CORT + imipramine-treated group (n = 10). Mice were administered CORT (100 μg/mL; Sigma-Aldrich, St. Louis, MO, United States) in place of drinking water for 14 days. Animal were weaned with 50 μg/mL CORT for 3 days and then with 25 μg/mL CORT for 3 days to allow for gradual recovery of endogenous corticosterone secretion. NYT (500 or 1000 mg/kg/day) was orally administered once daily from day 21 to day 49. As a positive control, imipramine (10 mg/kg/day, intraperitoneally (i.p.); Wako Pure Chemical, Osaka, Japan) was administered once daily. Subsequent behavioral tests were performed on days 50–64 and brain samples were collected on day 65. On the days behavioral tests were performed, the drugs were administered 30 min before the tests. A 5-bromo-2-deoxyuridine (BrdU) solution (50 mg/kg/day, i.p.; Sigma-Aldrich) was administered from day 15 to day 19.
4
Imipramine N-oxide Synthesis and Purification
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Imipramine N-oxide was synthesized, as described by Craig and Purushothaman (1970 ), and separated by high-performance liquid chromatography (HPLC), as described below. Imipramine, desipramine, glucose 6-phosphate dehydrogenase, NADP, and glucose 6-phosphate were obtained from Wako Pure Chemicals (Osaka, Japan). Gentamicin sulfate and amphotericin B were purchased from Sigma-Aldrich (St. Louis, MO). Dulbecco’s modified Eagle’s medium: nutrient mixture F-12 (D-MEM/F-12), heparin, piperazine-N′-(2-ethane-sulfonic acid) (HEPES), dispase, epidermal growth factor (EGF), fetal bovine serum (FBS), and donor horse serum (HS) were obtained from Gibco BRL, Life Technologies (Rockville, MD). Donkey serum was purchased from Abcam plc (Cambridge, UK). Dextran T-70 and Percoll were obtained from Pharmacia (Uppsala, Sweden). Collagenase P was purchased from Boehringer Mannheim (Mannheim, Germany). Anti-rat CYP2C11, CYP3A2, CYP1A1, and CYP2B1 goat sera and normal goat serum were purchased from Daiichi Pure Chemicals (Tokyo, Japan). Acetylated low-density lipoprotein labeled with a fluorescent probe, 1,1′-dioctadecyl-3,3,3′,3′ tetramethyl-indocarbocyamine perchlorate (DiI-Ac-LDL), was obtained from Biomedical Technologies (Stoughton, MA). All other chemicals were of reagent grade and commercially available.
5
Chemicals and Reagents for Neuroscience Research
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Ethylenediamine-N,N,N',N'-tetraacetic acid (EDTA) was obtained from Dojindo (Kumamoto, Japan). Fluoxetine, imipramine, venlafaxine, bupropion, and other chemicals were obtained from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan).
6
Comprehensive Catalog of Pharmaceutical Compounds
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Amikacin, caffeine, citrate, clozapine, dexamethasone, glimepiride, imipramine, ketotifen, lactose, sorbitol, and theophylline were purchased from Wako Pure Chemical Industries (Osaka, Japan). 3-Acetamidophenol, amiodarone, amitriptyline, ascorbate, perhexiline, and tamoxifen were purchased from Sigma-Aldrich (St. Louis, MO, USA). Chlorpromazine, desloratadine, isoproterenol, loratadine, maprotiline, and tilorone were purchased from Tokyo Chemical Industries (Tokyo, Japan). All compounds were of the highest available commercial grade.
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