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19 protocols using lauroglycol fcc

1

Topical Nanoemulsion Formulation Development

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PV was obtained as a gift sample from Qingdao Sigma Chemical Co., Ltd. Shandong, China. Basil oil, thyme oil, peppermint oil, rosemary oil, LO, citronella oil, verbena oil, and camphor oil were procured from Jiangxi Origin Aromatics Co., Ltd. Jiangxi, China. Tween80, Span80, Steareth-2, Steareth-21, Labrasol, Labrafil 1944, Brij 30, Lauroglycol-FCC, Lutrol-E400, propylene glycol, and Transcutol were obtained as gift samples from Gattefosse (Saint-Priest, France).
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2

Formulation Development of LCZ Nanoemulsion

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LCZ was purchased from Macklin Biochemical Co., Ltd. (Shanghai, China); oleic acid was obtained from Tokyo Chemical Industries Co., Ltd. (Tokyo, Japan); propylene glycol dicaprylate (PGD) and castor oil were obtained from Hunan Erkang Pharmaceutical Co., Ltd. (Hunan Province, Changsha, China); Cremophor® RH (RH40), Cremophor® EL35 (EL35) and Kolliphor® HS15 (HS15) were obtained from BASF SE (Ludwigshafen, Germany); Tween 80 was obtained from Jinshan Pharmaceutical Co., Ltd. (Sichuan Province, Meishan, China); polyethylene glycol 400 (PEG400) was purchased from Solarbio Life Science (Beijing, China); Capryol 90, Lauroglycol™ FCC, Lauroglycol and Transcutol® P were received as gifts from Gattefosse (Lyon, France). Methanol and acetonitrile (HPLC grade) were obtained from Merck (Darmstadt, Germany) and Tedia (Fairfield, OH, USA), respectively. Other reagents (analytical grade) were purchased from commercial suppliers.
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3

Rosuvastatin Calcium Lipid-based Formulations

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Rosuvastatin calcium was gifted by Mepro Pharmaceuticals Pvt. Ltd., Surendranagar, Gujarat, India. Peceol, Labrasol, Transcutol P, Labrafil M, Labrafil M, Lauroglycol FCC and Capryol 90 were gifted by Gattefosse India Pvt. Ltd, Mumbai, India. Cremophore EL was gifted from BASF India Ltd., Mumbai, India. Sefsol was gifted from Nikko Chemicals, Japan. Polyethylene glycol 400, Propylene glycol, Tween 80, Tween 20, Span 20, Span 80, Oleic acid, Castor oil, Olive oil, Cotton-seed oil, Sesame oil and Almond oil were purchased from Seva fine chemical ltd, Ahmedabad, Gujarat, India. Methanol AR grade was purchased from SD fine chem Ltd, Mumbai, India. All other materials and chemicals used were of either pharmaceutical or analytical grade.
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4

Comprehensive Pharmaceutical Ingredient Sourcing

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LUT was obtained from Beijing Mesochem Technology Pvt. Ltd. (Beijing, China). Lauroglycol-90, Lauroglycol-FCC, Capryol-90, Capryol-PGMC, Labrasol, and Transcutol-HP were obtained from Gattefosse (Lyon, France). Triacetin was obtained from Alpha Chemica (Mumbai, India). Chromatography grade acetonitrile, Tween-80, and sesame oil were obtained from Sigma-Aldrich (St. Louis, MO, USA). Cremophor-EL was obtained from BASF (Cheshire, UK). EG, PG, ethanol, and IPA were obtained from E-Merck (Darmstadt, Germany). Chromatography grade water was collected from Milli-Q water purification. All other chemicals and reagents used were of analytical/pharmaceutical grades.
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5

Oregano Oil Formulation Development

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Oregano oil was gifted by Qingdao Sigma Chemical Co., Ltd., Shandong, China. Pluracare L64 (a triblock copolymer with an average molecular weight of approximately 2900 and consisting of propylene oxide and ethylene oxide [HLB = 15]) was purchased from BASF SE Chemical Company (Ludwigshafen, Germany). Lauroglycol FCC (propylene glycol monolaurate [HLB=5]) was acquired as a gift from Gattefosse (Saint-Priest, France). Glycofurol (ethoxylate of tetrahydrofurfuryl alcohol) was obtained from Sigma Aldrich (St. Louis, Missouri, USA). All other chemicals were of analytical grade or better.
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6

Tolvaptan Formulation Optimization

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Tolvaptan (purity > 98.5%) was provided by Hwail Pharm (Pyeongtaek, Korea). Triethyl citrate, PeceolTM (glyceryl monooleate, type 40), Maisin® CC (glyceryl monolinoleate), Lauroglycol® 90 (propylene glycol monolaurate type II), Lauroglycol® FCC (propylene glycol monolaurate type I), Cremophor® RH40 (PEG-40 hydrogenated castor oil), Capryol® 90 (propylene glycol monocaprylate type II), Labrafil® M 2125 CS (laouroyl polyoxyl-6-glecerides), Labrafil® M 1944 CS (oleoyl polyoxyl-6-glycerides), Labrafac® lipophile WL 1349 (medium-chain triglyceride), Labrasol® (caprylocapryl polyoxyl-8-glycerides), and Transcutol® HP (diethylene glycol monoethyl ether) were obtained from Gattefosse (Saint-Priest, France). Tween (polyethylene glycol sorbitan monolaurate) 20, Tween 40, Tween 80, polyethylene glycol (PEG) 200, PEG 400, castor oil, and oleic acid were purchased from Daejung (Seoul, Korea). Methanol and acetonitrile (HPLC grade) were purchased from Duksan (Seoul, Korea). All other chemicals and reagents were of analytical grade.
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7

Formulation and Evaluation of Multi-Functional Dermal Emulsions

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GM was obtained from Delta Pharma Co. (10th of Ramadan, Egypt). Peppermint, bergamot, mandarin, tea tree, eucalyptus, fennel, lavender, rosemary, orange, and lemon oils were provided by Nefertari Natural Body Care Line (Cairo, Egypt). Labrafil isostearic, labrafil M 1944 CS, transcutol P, and lauroglycol FCC were kindly gifted from Gattefossé Co. (Saint-Priest, France). Tween 80, propylene glycol (PG), ethanol, and glycerin were purchased from El-Nasr Pharmaceutical Chemicals (Cairo, Egypt). Tween 20 was purchased from Oxford Lab Chem (Vasai, India). Span 20 and Span 85 were purchased from Sigma Chemical Co., St. Louis, MO, USA. Polyethylene glycol 400 (PEG 400) was procured from Fluka Chemie AG (Buchs, Switzerland). Carbopol 934, carbopol 940, sodium carboxymethyl cellulose (Na-CMC), sodium alginate, and hydroxypropyl methyl cellulose (HPMC) were provided by EIPICO Co. (10th of Ramadan, Egypt).
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8

Nanoemulsion Formulation and Characterization

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SMV was acquired as a generous gift from the Saudi Arabian Japanese (SAJA) Pharmaceutical Company Limited (Jeddah, Saudi Arabia). Coconut oil was purchased from Avanti Polar Lipids (Alabaster, AL, USA). Cremophor EL was purchased from Sigma-Aldrich Co. (St Louis, MO, USA). Lauroglycol™ FCC was a gift from Gattefosse (Saint-Priest, France). High-performance liquid chromatography–grade methanol and acetonitrile were obtained from Merck (Darmstadt, Germany). Chloroform, absolute ethanol, phosphate buffer pH 7.4, and 0.9% normal saline were purchased from Fisher Scientific UK (Loughborough, Leicestershire, UK). Water was obtained from a Milli-Q water purification system (Millipore, Bedford, MA, USA). All other reagents and chemicals were of analytical grade.
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9

Formulation Development of Sildenafil Citrate

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Sildenafil (base) was supplied by Huons Pharm. Co. (Ansan, South Korea). Polyvinylpyrrolidone (PVP, K30), Solutol HS15 and Cremophor EL were purchased from BASF (Ludwigshafen, Germany). Dextran, polyvinyl alcohol (PVA), hydroxypropyl methylcellulose 2910 (HPMC), pyrogenic silica (HDK N20 Pharma), hydroxypropyl cellulose low viscosity (HPC-L), carboxymethyl cellulose sodium (Na-CMC), poloxamer 188, PEG 4000 and hydroxypropyl beta-cyclodextrin (HP-β-CD) were kindly offered from Hanmi Pharm. Co. (Suwon, South Korea). Soybean oil, sorbitan monooleate (Span 80), olive oil, polysorbate (Tween 80) and corn oil were provided by Daejung Chem. Co. (Siheugn, South Korea). Peceol, Capryol 90 (propylene glycol monocaprylate), Plurol diisosterarique, Labrafil M2125CS, Transcutol HP, Lauroglycol FCC and Labrasol were acquired from Gattefosse (Saint-Priest Cedex, France). Medium-chain triglycerides (Captex 300) were purchased from Abitec (Columbus, OH, USA). Mineral oil and linseed oil were obtained from Samchun Chemical Co. (Pyeongtaek, South Korea). Gelatin and sesame oil were purchased from Wako Chemicals Co. (Tokyo, Japan). All other chemicals and solvents were of reagent grade; they were used with or without further purification.
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10

Lipid-Based Nanoformulation Preparation

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PQ phosphate was obtained from Sigma-Aldrich, USA. Tween® 80 and Span® 80 were supplied by Acros Organics, USA. Compritol® 888 ATO, Precirol® ATO 5, Geleol™ Mono and Diglycerides NF, Lauroglycol™ FCC and Gelucire® 43/01 were obtained from Gattefossé, USA. Solutol® HS 15 was supplied by BASF, USA. Poloxamer® 188, Miglyol® 829, olive oil, soybean oil, corn oil, sesame oil, oleic acid, and castor oil were purchased and used as received. Amicon® Ultra centrifugal filter units (Molecular weight cut off (MWCO) 100 kDa) were purchased from Millipore, USA. Fasted-state simulated gastric fluid (FaSSGF) and fasted-state simulated intestinal fluid (FaSSIF) powder were purchased from Biorelevant, UK. Sprague Dawley rat red blood cells (catalog number: IRTSDRBC 10 ML) were purchased from Innovative Research, USA. All other chemicals and solvents were of analytical or high-performance liquid chromatography (HPLC) grade.
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