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1 4 butanediol diacrylate

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1,4-Butanediol diacrylate is a chemical compound used in laboratory settings. It is a colorless liquid with a viscous consistency. The primary function of 1,4-Butanediol diacrylate is to serve as a crosslinking agent in the synthesis of polymers and other materials.

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Lab products found in correlation

1 3 aminopropyl 4 methylpiperazine e7, by Thermo Fisher Scientific (2 mentions) 4 amino 1 butanol, by Thermo Fisher Scientific (2 mentions) Celltiter 96 aqueous one mts assay, by Promega (1 mentions) Ganciclovir, by InvivoGen (1 mentions) Pcdna3.1 vector, by Thermo Fisher Scientific (1 mentions) 4 dimethylaminopyridine, by Thermo Fisher Scientific (1 mentions) N n dicyclohexylcarbodiimide, by Thermo Fisher Scientific (1 mentions) Ethyl ether anhydrous, by Thermo Fisher Scientific (1 mentions) Anhydrous dimethyl sulfoxide dmso, by Merck Group (1 mentions) Tetrahydrofuran thf, by Merck Group (1 mentions) Chlorpromazine hydrochloride, by Merck Group (1 mentions) Transferrin, by Thermo Fisher Scientific (1 mentions) Genistein, by Merck Group (1 mentions) Fetal bovine serum (fbs), by Thermo Fisher Scientific (1 mentions) Gwiz luc, by Aldevron (1 mentions) Filipin 3, by Merck Group (1 mentions) 5 n ethyl n isopropyl amiloride, by Merck Group (1 mentions) Cholera toxin b, by Thermo Fisher Scientific (1 mentions) Dodecylamine, by Merck Group (1 mentions) Dynasore hydrate, by Merck Group (1 mentions)

Close spelling variants of this product

1,4-butanediol diacrylate (B4; 1,4-Butanediol diacrylate (B4), 5-amino-1-pentanol (S5), 1,4-butanediol

5 protocols using 1 4 butanediol diacrylate

1

Multifunctional Polymer Synthesis and Evaluation

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1,4-butanediol diacrylate (B4), 4-amino-1-pentanol (S4), 5-amino-1-pentanol (S5), 1-(3-aminopropyl)-4-methylpiperazine (E7)
(Alfa Aesar), 1,5-pentanediol diacrylate (B5) (Monomer Polymer & Dajac Labs), 2-methylpentane-1,5-diamine (E4) (TCI
America), 2-(3-aminopropylamino)ethanol (E6) (Fluka), poly(ethylene glycol) methyl ether thiol (800 Da), branched 25 kDa
poly(ethylenimine) (PEI) (Sigma-Aldrich), α-Mercaptoethyl-ω-methoxy polyoxyethylene (5000 Da) (NOF America
Corporation), and cell culture media components were purchased and used as received. pEGFP-N1 (EGFP) DNA (purchased from Elim
Biopharmaceuticals and amplified by Aldevron, Fargo, ND), ganciclovir (Invivogen, San Diego, CA), Label IT-Tracker Cy3 kit (Mirus
Bio LLC), and CellTiter 96 AQueous One MTS assay (Promega, Fitchburg, WI) were obtained from commercial vendors and used per
manufacturer’s instructions. HSV-tk gene was cloned into the pcDNA3.1 vector (Life Technologies) and amplified (Aldevron,
Fargo, ND).
Kim J., Kang Y., Tzeng S.Y, & Green J.J. (2016). Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy. Acta biomaterialia, 41, 293-301.
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2

Synthesis and Application of Histidine-Based Conjugate

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1,4-Butanediol diacrylate (90%), 4-amino-1-butanol (98%), 4-dimethylaminopyridine (99%), N,N′-dicyclohexylcarbodiimide (99%), N-cbz-L-histidine, 10% Pd-C, methylene chloride, and ethyl ether were purchased from Alfa Aesar (Ward Hill, MA, USA). pMyD88 and the negative control plasmid containing nonspecific shRNA sequence (pHK) were both designed and synthesized by Genesil Biotechnology (Wuhan, People’s Republic of China). Sprague Dawley rats and Lewis rats weighing approximately 250 g were obtained from the Experimental Animal Center of China’s Military Academy of Medical Sciences (Beijing, People’s Republic of China). DA rats were obtained from the Experimenta Animal Center of the Second Affiliated Hospital of Harbin Medical University (Harbin, People’s Republic of China).
Hu F., Wang H., Zhang S., Peng Y., Su L., Chang J, & Liu G. (2015). Inhibition of myeloid differentiation factor 88 signaling mediated by histidine-grafted poly(β-amino ester) ester nanovector induces donor-specific liver allograft tolerance. International Journal of Nanomedicine, 10, 4367-4382.
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3

Reagent Synthesis for Polymer Development

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The reagents were purchased from different companies as follows: 1,4-butanediol diacrylate and 4-amino-1-butanol from Alfa Aesar (Ward Hill, MA); 1,3-diaminopropane (C1) from Sigma-Aldrich (St. Louis, MO); 2-(3-aminopropylamino)ethanol (C5) from Oakwood Chemical (West Columbia, SC); methoxy-PEG-succinimidyl succinate from JenKem Technology (Plano, TX). Solvents were purchased as follows: anhydrous ethyl ether from Fischer Scientific (Pittsburgh, PA); dimethyl sulfoxide anhydrous (DMSO) and tetrahydrofuran (THF) from Sigma-Aldrich.
Mastorakos P., Zhang C., Song E., Kim Y.E., Park H.W., Berry S., Choi W.K., Hanes J, & Suk J.S. (2017). Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors. Journal of controlled release : official journal of the Controlled Release Society, 262, 37-46.
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4

Cellular Uptake Mechanisms Evaluation

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1,4-Butanediol diacrylate and 5-amino-1-pentanol were purchased from Alfa Aesar (Ward Hill, MA, USA). Dodecylamine was purchased from Sigma-Aldrich (St. Louis, MO, USA). (PEO)4-bisamine (“122”) was acquired from Molecular Biosciences (Boulder, CO, USA). All chemical reagents were used without further purification. Plasmids encoding green fluorescent protein (gWiz-GFP) and firefly luciferase (gWiz-Luc) were purchased from Aldevron (Fargo, ND, USA). jetPEI (Polyplus Transfection, Illkirch, France) and Lipofectamine 2000 were purchased from VWR (Radnor, PA, USA) and Invitrogen (Carlsbad, CA, USA), respectively. Transferrin, cholera toxin B, and 10 000 MW dextran, each labeled with AlexaFluor 647, were purchased from Invitrogen. Cytochalasin D, dynasore hydrate, chlorpromazine hydrochloride, filipin III, genistein, methyl-β-cyclodextrin, 5-(N-ethyl-N-isopropyl)amiloride, and U18666A were obtained from Sigma-Aldrich. Immortalized mouse embryonic fibroblast cell lines were cultured in DMEM (Invitrogen) supplemented with 10% fetal bovine serum (Invitrogen).
Eltoukhy A.A., Sahay G., Cunningham J.M, & Anderson D.G. (2014). Niemann-Pick C1 Affects the Gene Delivery Efficacy of Degradable Polymeric Nanoparticles. ACS Nano, 8(8), 7905-7913.
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5

Tailored Biomaterial Synthesis Protocol

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1,4-Butanediol diacrylate (B4), 1,6-hexanediol diacrylate (B6), 1-(3-aminopropyl)-4-methylpiperazine (E7) (Alfa Aesar), octylamine (S8m), decylamine (S10m), acetone, dimethyl sulfoxide (DMSO), dimethylformamide (DMF), tetrahydrofuran (THF), hexane, citric acid monohydrate, disodium phosphate (Sigma-Aldrich, St. Louis, MO, USA), methoxy poly(ethylene glycol) thiol (2 kDa and 800 Da) (Laysan Bio, Inc.), and Verteporfin (VP (US Pharmacopeial Convention, Inc.) were purchased and used as received.
Shamul J.G., Shah S.R., Kim J., Schiapparelli P., Vazquez-Ramos C.A., Lee B.J., Patel K.K., Shin A., Quinones-Hinojosa A, & Green J.J. (2019). Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics. International Journal of Nanomedicine, 14, 10047-10060.
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