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Pre 084 hydrochloride

Manufactured by Merck Group
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PRE-084 hydrochloride is a synthetic chemical compound used as a research tool in laboratory settings. It serves as a selective agonist for the sigma-1 receptor. The core function of this product is to facilitate the study of the sigma-1 receptor and its associated biological processes.

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Lab products found in correlation

Dextromethorphan, by Merck Group (2 mentions) Fluvoxamine maleate f2802, by Merck Group (2 mentions) Ne 100 hydrochloride, by Merck Group (2 mentions)

Spelling variants of this product

PRE-084 (7 citations) Hydrochlorides (2 citations)

2 protocols using pre 084 hydrochloride

1

Molecular Docking of SIGMAR1 Agonists

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
Fluvoxamine maleate (F2802, Sigma-Aldrich), PRE-084 hydrochloride (Cat. No. 0589, TOCRIS), dextromethorphan (D2531, Sigma-Aldrich), NE-100 hydrochloride (Cat. No. 3133, TOCRIS) were dissolved in distilled water into stock solutions with a concentration of 10mM or 25mM. The stock solutions were stored in −80 °C and thawed only once for in vitro experiments. The putative binding of these agonists in SIGMAR1 was obtained using known templates in the SWISS-MODEL (Biozentrum) that produced a high identity with human SIGMAR1 structure (5HK1 and 5HK2)14 (link). This was used to generate docking models that were visualized using CueMol2.
Song L., Bekdash R., Morikawa K., Quejada J.R., Klein A.D., Aina-Badejo D., Yoshida K., Yamamoto H.E., Chalan A., Yang R., Patel A., Sirabella D., Lee T.M., Joseph L.C., Kawano F., Warren J.S., Soni R.K., Morrow J.P, & Yazawa M. (2022). Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nature cardiovascular research, 1(2), 142-156.
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2

Molecular Docking of SIGMAR1 Agonists

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
Fluvoxamine maleate (F2802, Sigma-Aldrich), PRE-084 hydrochloride (Cat. No. 0589, TOCRIS), dextromethorphan (D2531, Sigma-Aldrich), NE-100 hydrochloride (Cat. No. 3133, TOCRIS) were dissolved in distilled water into stock solutions with a concentration of 10mM or 25mM. The stock solutions were stored in −80 °C and thawed only once for in vitro experiments. The putative binding of these agonists in SIGMAR1 was obtained using known templates in the SWISS-MODEL (Biozentrum) that produced a high identity with human SIGMAR1 structure (5HK1 and 5HK2)14 (link). This was used to generate docking models that were visualized using CueMol2.
Song L., Bekdash R., Morikawa K., Quejada J.R., Klein A.D., Aina-Badejo D., Yoshida K., Yamamoto H.E., Chalan A., Yang R., Patel A., Sirabella D., Lee T.M., Joseph L.C., Kawano F., Warren J.S., Soni R.K., Morrow J.P, & Yazawa M. (2022). Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nature cardiovascular research, 1(2), 142-156.
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