Ecat hr

Manufactured by Siemens

Sourced in United States

The ECAT HR+ is a high-resolution positron emission tomography (PET) scanner designed for clinical research and advanced medical imaging applications. It features a compact design and delivers high-quality, high-resolution images. The ECAT HR+ is capable of producing detailed, three-dimensional images of the body's internal structures and processes.

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Lab products found in correlation

3t triotim, by Siemens (1 mentions) Gemini tf64, by Philips (1 mentions) 4 ring biograph mct, by GE Healthcare (1 mentions) Advance pet, by GE Healthcare (1 mentions) Discovery ls pet ct, by GE Healthcare (1 mentions)

21 protocols using ecat hr

PET Imaging Protocol for Anesthetized Animals

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After a 12-h fasting period, the animals were anesthetized using the same conditions than those described for CT-scan measurements. The animals were placed in ventral recumbency on the bed of a whole-body high-resolution PET and a venous catheter was inserted into their left ear in order to inject the radiolabel. The ears and eyes of the animals were sealed with cotton and surgical tape, respectively, to minimize auditory and visual stimulations. The body PET data were acquired on a CTI/Siemens HR+ Scanner in 3D mode (Siemens ECAT, HR+).
A 30-min 3D emission scan was performed using an axial field of view of 15.52 cm. It was corrected for attenuation by a 15-min transmission scan using rotating 68-Ge rods. Following scatter, dead time and random corrections, PET transaxial images were obtained by iterative reconstruction using a ramp filter (Kernel FWHM = 6 mm) providing 63 contiguous slices. Spatial resolution after reconstruction was 0.64 mm per pixel in the x and y directions and 2.42 mm per pixel in the z-axis. Pixel depth was encoded using the Standard Uptake Value (SUV) method.

Malbert C.H., Val-Laillet D., Meurice P., Lallès J.P, & Delarue J. (2022). Contrasted central effects of n-3 versus n-6 diets on brain functions in diet-induced obesity in minipigs. Nutritional neuroscience, 25(7).

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Multimodal Neuroimaging Protocol for [18F]fallypride PET and MRI

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A magnetized prepared rapid gradient echo (MP-RAGE) magnetic resonance image (MRI) was acquired using a Siemens 3T Trio-Tim for anatomic coregistration and processing of PET data. Acquisition of [¹⁸F]fallypride (FAL) data was similar to that described previously (Albrecht et al. 2014 (link)). Briefly, FAL was synthesized in the Department of Radiology and Imaging Sciences radiochemistry facilities (Gao et al. 2010 (link)). FAL PET scans were acquired on a Siemens ECAT HR+ (3D mode; septa retracted). FAL PET scans were initiated with an IV FAL infusion into the antecubital vein over the course of 1.5 minutes. The dynamic PET acquisition was split into two segments for subject comfort (Christian et al. 2006 (link)). The first half of dynamic acquisition was 70 min (6 × 30s, 7 × 60s, 10 × 120s, 10 × 300s). Following this segment, the subject was removed from the scanner for a ~20 min break period to stretch and use the restroom if needed. The second half of dynamic acquisition lasted 80 min (16 × 300s). A schematic of the scan day timeline is shown in Online Resource 1.

Albrecht D.S., MacKie P.J., Kareken D.A., Hutchins G.D., Chumin E.J., Christian B.T, & Yoder K.K. (2016). DIFFERENTIAL DOPAMINE FUNCTION IN FIBROMYALGIA. Brain imaging and behavior, 10(3), 829-839.

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Fasting and Caffeine Abstention for PET

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Participants were instructed to fast for >6 h and to abstain from caffeine-containing products for >24 h prior to PET studies [22, 23] . Smokers were also instructed to refrain from smoking for >12 h before the PET studies [5, 19] . Participants were positioned with the heart roughly centered in the field of view in a whole-body PET scanner (ECAT HR+, Siemens/CTI Knoxville, TN, USA).

Ochi N., Yoshinaga K., Ito Y.M., Tomiyama Y., Inoue M., Nishida M., Manabe O., Shibuya H., Shimizu C., Suzuki E., Fujii S., Katoh C, & Tamaki N. (2016). Comprehensive assessment of impaired peripheral and coronary artery endothelial functions in smokers using brachial artery ultrasound and oxygen-15-labeled water PET. Journal of cardiology, 68(4).

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FDOPA PET Imaging Protocol for Neurological Assessment

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A full-ring PET/computed tomography (CT) scanner (ECAT-HR; Siemens, Knoxville, TN, USA) was used to obtain PET images after the subjects fasted for more than four hours. A CT was performed before the PET scan for attenuation correction. FDOPA was synthesized and injected intravenously, following previously reported procedures 23, (link)24 (link) . Three-dimensional FDOPA emission data were obtained for 30 minutes, and the data were integrated between 10 and 30 minutes following the injection to obtain 20minute static FDOPA images after reconstruction. FDOPA PET images were reconstructed using an ordered-subset expectation maximization iterative reconstruction algorithm with six iterations and eight subsets 25, (link)26 . Then, a Gaussian lter with a full width at half maximum of 4 mm was applied. The resulting voxel sizes were 1.34 × 1.34 × 3 mm for FDOPA PET images. SUV maps of FDOPA were calculated based on the radioactive activity divided by the decay-corrected injected dose per body mass. Resulting SUV maps were subsequently normalized (nSUV) relative to the median value of the normalappearing striatum 22, (link)27 (link) .

Tatekawa H., Uetani H., Hagiwara A., Bahri S., Raymond C., Lai A., Cloughesy T.F., Nghiemphu P.L., Liau L.M., Pope W.B., Salamon N, & Ellingson B.M. (2021). Worse prognosis for IDH wild-type diffuse gliomas with larger residual biological tumor burden. Annals of nuclear medicine, 35(9).

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Glucose Metabolism and Dopamine Binding

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Subjects had two imaging visits: on one day of study (Day A) the subject took a 75 gram oral glucose drink (Trutola, VWR, PA); on the other day (Day B) the subject took an oral placebo drink (sucralose, 0.348 mg/ml [JK Sucralose Inc., NJ] that is of equal volume and sweetness level to the glucose solution). PET started at 10 minutes after completion of the glucose/placebo drink. PET scans were run on a Siemens ECAT HR+ and [¹¹C]raclopride was prepared according to methods published previously [15] (link). Scans were started immediately after tracer injection of 8 mCi or less of [¹¹C]raclopride and carried out for a total of 60 minutes. Blood samples for glucose levels were obtained prior to the drinks, immediately upon completion of the glucose/placebo drink, then every 5 minutes for 30 minutes, at 60, 90 & 120 minutes. PET was carried out at the approximate same time of day for all subjects. Subjects were asked to fast and stay hydrated overnight (at least 12 hours) prior to the start of any study procedures on each day of imaging study. Days A and B were randomized across subjects. These two scan days were separated between 2–42 days with an average of 16±10 days.

Wang G.J., Tomasi D., Convit A., Logan J., Wong C.T., Shumay E., Fowler J.S, & Volkow N.D. (2014). BMI Modulates Calorie-Dependent Dopamine Changes in Accumbens from Glucose Intake. PLoS ONE, 9(7), e101585.

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PET Imaging of 18F-FLT Uptake

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At VUMC, PET imaging was done using a full ring PET-CT scanner (Philips Gemini TF64). Acquisitions (3 min/bed) started approximately 60 min after about 185 MBq 18 F-FLT iv, covering a skull mid-thigh trajectory. At TUM, a full ring PET scanner (ECAT HR+, Siemens/CTI) was used, acquisition starting 45 min after approximately 300 MBq 18 F-FLT iv. Circular regions of interest were drawn semi-automatically containing the area of increased 18 F-FLT uptake to calculate standardized uptake values (SUV) as described before
[7 (link),10 (link)]. Maximum values of 18 F-FLT-SUV were calculated for all biopsied lesions, all larger than 3 cc, minimizing partial volume effects.

Wondergem M.J., Herrmann K., Syrbu S., Zijlstra J.M., Hoetjes N., Hoekstra O.S., Cillessen S.A., Moesbergen L.M., Buck A.K., Vose J.M, & Juweid M.E. (2014). 18 F-fluorothymidine uptake in follicular lymphoma and error-prone DNA repair. EJNMMI Research, 4, 3.

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Amyloid and Dopamine Receptor Imaging

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Subjects underwent a 10 minute acquisition (1×10 frame or 2×5 minutes frames), 50 minutes after intravenous injection of 10 mCi (370 MBq) of florbetapir F 18. For the florbenazine imaging session, an i.v. bolus of 5 mCi (185 MBq) of 18 F-AV-133 was administered. Brain scans were acquired over an approximately 10 min period, 50 minutes after injection. For both tracers, data was acquired from 3 sites, including 2 PET/CT scanners: Biograph 2 slice PET/CT and Biograph mCT 40 slice PET/CT and a dedicated PET scanner (ECAT HR+) all manufactured by Siemens Medical Solutions, Knoxville, TN. Images were reconstructed using iterative reconstruction. No post-reconstruction technique, such as smoothing or partial volume correction, was applied to the images.

Siderowf A., Pontecorvo M.J., Shill H.A., Mintun M.A., Arora A., Joshi A.D., Lu M., Adler C.H., Galasko D., Liebsack C., Skovronsky D.M, & Sabbagh M.N. (2014). PET imaging of amyloid with Florbetapir F 18 and PET imaging of dopamine degeneration with 18F-AV-133 (florbenazine) in patients with Alzheimer’s disease and Lewy body disorders. BMC Neurology, 14, 79.

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Quantitative PET Imaging of FLT Tracer

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3'-deoxy-3'-[¹⁸F]fluorothymidine was synthesized as previously described [40 ]. Imaging was performed on a whole-body high resolution PET scanner (ECAT HR+; Siemens/CTI; Knoxville, TN). This device simultaneously acquires 47 contiguous slices with a slice thickness of 3.4 mm. The in-plane image resolution of transaxial images was approximately 8 mm full width at half maximum (FWHM), with an axial resolution of approximately 5 mm FWHM.
Static emission images were acquired 45 minutes after injection of approximately 300 MBq FLT (range: 270 – 340 MBq). Emission data were corrected for random coincidences, dead time and attenuation and reconstructed by filtered backprojection (Hanning filter with cut-off frequency 0.4 cycle per bin). The matrix size was 128 × 128 pixels with a pixel size of 4.0 × 4.0 mm. The image pixel counts were calibrated to activity concentrations (Becquerel/milliliter) and decay corrected using the time of tracer injection as reference.

Herrmann K., Buck A.K., Schuster T., Abbrederis K., Blümel C., Santi I., Rudelius M., Wester H.J., Peschel C., Schwaiger M., Dechow T, & Keller U. (2014). Week one FLT-PET response predicts complete remission to R-CHOP and survival in DLBCL. Oncotarget, 5(12), 4050-4059.

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PET Imaging of Amyloid Burden

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A target dose of 15 mCi of [¹¹C]PiB was delivered intravenously while participants were resting outside the PET scanner. PET data were acquired following a 40-minute radiotracer uptake period using either a Siemens ECAT HR+ (UW and UPMC), a Siemens 4-ring Biograph mCT (UPMC), or GE Advance (UC) scanner. The time-series acquisition was performed from 40 to 70 min (post-injection) with data binned into 5-minute time frames. PET images were reconstructed with the ECAT system software (OSEM algorithm; 4 iterations, 16 subsets) to a voxel size of 2.57 mm × 2.57 mm × 2.43 mm and matrix dimension of 128 × 128 × 63 with corrections for detector deadtime, scanner normalization, photon attenuation and scatter, and radioactive decay. PET scans were reoriented along the anterior commissure posterior commissure (AC-PC) line, and inter-frame motion was corrected (Woods et al., 1998 (link)). Standard uptake value ratio (SUVR) images were calculated from PET data 50–70 min post-injection (McNamee et al., 2009 (link)) with a cerebellar gray matter reference region. (Klunk et al., 2004 (link), Lopresti et al., 2005 (link), Price et al., 2005 (link)) Global Aβ burden was calculated using the amyloid load metric (Aβ_L) following previously described methodology (Zammit et al., 2020a ).

Bazydlo A.M., Zammit M.D., Wu M., Lao P.J., Dean DC I.I.I., Johnson S.C., Tudorascu D.L., Cohen A., Cody K.A., Ances B., Laymon C.M., Klunk W.E., Zaman S., Handen B.L., Hartley S.L., Alexander A.L, & Christian B.T. (2021). White matter microstructure associations to amyloid burden in adults with Down syndrome. NeuroImage : Clinical, 33, 102908.

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PET Imaging with 18F-FLT Radiotracer

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3’-Deoxy-3’-[¹⁸F] fluorothymidine was synthesised as described previously [27 ]. Imaging was performed on a whole-body high-resolution PET scanner (ECAT HR+; Siemens/CTI; Knoxville, TN). The scanner simultaneously acquires 47 contiguous slices with a slice thickness of 3.4 mm. The in-plane resolution of transverse images was approximately 8 mm full width at half maximum (FWHM), with an axial resolution of approximately 5 mm FWHM. Static emission images were acquired 45 minutes after injection of approximately 300 MBq FLT (range: 270–340 MBq). Emission data were corrected for random coincidences, dead time and attenuation and were reconstructed by filtered back projection (Hanning filter with cut-off frequency of 0.4 cycles per bin). The matrix size was 128 x 128 pixels with a pixel size of 4.0 x 4.0 mm. The image pixel counts were calibrated to activity concentrations (Becquerel/gram [Bq/g]) and decay corrected using the time of tracer injection as reference.

Wieder H., Beer A.J., Siveke J., Schuster T., Buck A.K., Herrmann K, & Stollfuss J.C. (2018). 18F-fluorothymidine PET for predicting survival in patients with resectable pancreatic cancer. Oncotarget, 9(11), 10128-10134.

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