Access dxl

Manufactured by Beckman Coulter

The Access DxL is an automated immunoassay analyzer designed for the detection and quantification of a wide range of analytes in clinical laboratory settings. It provides consistent and reliable results through its automated sample handling and advanced analytical capabilities.

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Lab products found in correlation

Alinity i, by Abbott (2 mentions) Cobas e801, by Roche (2 mentions) Advia centaur, by Siemens (1 mentions) Atellica im, by Siemens (1 mentions)

Spelling variants of this product

UniCel Dxl 800 Access Immunoassay System (7 citations) UniCel Dxl 600 Access Immunoassay System (3 citations) UniCel Dxl 800 Access Immunoassay analyser (2 citations) UniCel Dxl 800 Access (2 citations)

3 protocols using access dxl

Evaluating Iron Overload Using SF and MRI

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Iron overload was evaluated by direct and indirect methods namely by SF and Magnetic Resonance Imaging (MRI) T2* of liver and heart.
SF was measured by chemiluminescence immunoassays (Beckman Access Dxl). The normal reference range values are 30–350 ng/mL in males and 15–150 ng/mL in females. Generally, a cut-off value of SF concentration higher than 800 ng/mL indicates significant IOL.20 (link)
Reported global myocardial and liver IOL data, assessed by MRI and registered not more than 8 months before OGTT, were collected. The values were expressed in mg/g dry weight (d.w.) for LIC, classified into normal (LIC < 3), mild (LIC > 3 and < 7), moderate (LIC > 7 and < 14) and severe overload (LIC > 14).21 (link) A global heart T2* value < 20 ms was considered as a conservative cut-off for significant myocardial iron overload.22 (link)

de Sanctis V., Soliman A.T., Daar S., Tzoulis P., Di Maio S, & Kattamis C. (2023). Glucose Homeostasis and Assessment of β-Cell Function by 3-hour Oral Glucose Tolerance (OGTT) in Patients with β-Thalassemia Major with Serum Ferritin below 1,000 ng/dL: Results from a Single ICET-A Centre. Mediterranean Journal of Hematology and Infectious Diseases, 15(1), e2023006.

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Comparative Analysis of Folate Measurement

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We included in this study four MSs: Access Dxl (Beckman Coulter), Advia Centaur (Siemens Healthcare Diagnostics), Alinity i (Abbott Diagnostics) and Cobas e801 (Roche Diagnostics), all 'Conformité Européenne'/CE marked. According to the data from EQA schemes, these manufacturers cover ~85% of folate measurements [8] . The main MS characteristics are summarized in

Braga F., Frusciante E., Ferraro S, & Panteghini M. (2020). Trueness evaluation and verification of inter-assay agreement of serum folate measuring systems. Clinical chemistry and laboratory medicine, 58(10).

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Comparative Evaluation of PSA Assays

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Samples' preparation and measurements on the four analytical platforms Access Dxl (Beckman Coulter), Atellica IM (Siemens Healthcare Diagnostics), Alinity i (Abbott Diagnostics) and Cobas e801 (Roche Diagnostics) have been described elsewhere [4] . Also, the assay design and the characterization of the antibodies used were reported in the same paper [4] .
Briefly, we selected 135 and 137 leftover serum samples, from different patients, as a representative clinical sampling for the measurement of tPSA and fPSA, respectively of the daily clinical routine, excluding from the collection haemolyzed, lipemic or icteric samples, according to the interference thresholds reported by PSA assays. The leftover serum specimens were immediately separated into a total of four 400 µL aliquots (one for each of the analytical platforms evaluated in the study) and stored at -80 °C until analysis. The study design followed the Clinical and Laboratory Standards Institute EP-09 protocol concerning the procedure of sample collection and measurements [17] .

Ferraro S., Biganzoli G., Bussetti M., Castaldi S., Biganzoli E.M, & Plebani M. (2023). Managing the impact of inter-method bias of prostate specific antigen assays on biopsy referral: the key to move towards precision health in prostate cancer management. Clinical chemistry and laboratory medicine, 61(1).

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