Ly2109761

Manufactured by Adooq

Sourced in United States

LY2109761 is a chemical compound designed for use in laboratory research. It functions as a selective inhibitor. Further details about its specific applications or intended use are not available.

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Lab products found in correlation

3 protocols using ly2109761

Comprehensive Glioma Signaling Pathway Analysis

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Smad3 (phos-S208) (Abcam, ab138659), SERPINE1 (Fisher Scientific), Rap 1 (sc-398755) and TGF-β RI Kinase inhibitor V (Santa Cruz Biotechnology), PARP (#9542S), LC3 A/B (#4108S), ZYX, and total Smad3 (Cell Signaling Technology) antibodies were obtained from commercial vendors. Simvastatin was obtained from Sigma Chemical (in vitro stock and in vivo stock for subcutaneous GIC grafts) and Selleckchem (in vivo stock for GIC intracranially grafted mice). TGF-β2, mevastatin, fluvastatin, lovastatin, geranylgeranyl pyrophosphate (GGPP), farnesyl pyrophosphate (FPP) and (±)-mevalonolactone were obtained from Sigma Chemical. Silencer® select pre-designed SMAD3 siRNAs, and Silencer® Select Negative Control siRNA were purchased from Life Technology. LY2109761 was from AdooQ BioScience (A11133).

Xiao A., Brenneman B., Floyd D., Comeau L., Spurio K., Olmez I., Lee J., Nakano I., Godlewski J., Bronisz A., Kagaya N., Shin-ya K, & Purow B. (2019). Statins affect human glioblastoma and other cancers through TGF-β inhibition. Oncotarget, 10(18), 1716-1728.

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Chemical Treatments for Cell Studies

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Z-VAD-FMK, chloroquine (CQ), Rapamycin (Rapa), NU7441, Cyt387, A674563, KU60019, LY294002, PD0332991, AT7519, MK2206, CUDC907, LY2109761, GANT61, BIX 02189, Spautin-1, QNZ, LY317615, PD169316, GSK2606414, LYK974, TCK ERK 11e, SC79, MC1568, H89, ICG001, Perifosine, AEE788, ABT263, GDC-0941, FH535, PD0325025, NU7026, STF-083010, AEBSF HCl were purchased from Adooq. N-Acetyl-l-cysteine ethyl ester, DMSO, PEG300, and Tween-80 were purchased from MCE.

Cui B., Song L., Wang Q., Li K., He Q., Wu X., Gao F., Liu M., An C., Gao Q., Hu C., Hao X., Dong F., Zhou J., Liu D., Song Z., Yan X., Zhang J., Bai Y., Mao Q., Yang X, & Liang Z. (2023). Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors. Signal Transduction and Targeted Therapy, 8, 366.

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Mouse Lung Epithelial Cell Culture

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Mouse lung epithelial cells (MLE12; Procell Life Science & Technology Co., Ltd., Wuhan, China) were cultured in F12 medium (Shanghai Fuheng Biotechnology Co., Ltd., Shanghai, China) containing 10% fetal bovine serum (FBS) (Biochannel Company, Nanjing, China) under 37 °C and 5% CO₂, and cells at passages 3–5 were used for the experiments. TGF-β1 (PeproTech, USA), LY2109761 (a TGF-β1 receptor inhibitor; AdooQ Bioscience), and si-JAK2 (Guangzhou RiboBio Co., Ltd., Guangzhou, China) were used for subsequent in vitro experiments. Experiments were performed under a project license (No. Dossy20210119001) granted by the Ethics Committee of Chengdu Dashuo Biotechnology Co. (Chengdu, China), in compliance with institutional guidelines for the care and use of animals.

Yang Y., Wang X, & Zhang J. (2024). Pirfenidone and nintedanib attenuate pulmonary fibrosis in mice by inhibiting the expression of JAK2. Journal of Thoracic Disease, 16(2), 1128-1140.

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