Log In Sign up
The largest database of trusted experimental protocols

Sr49059

Manufactured by Merck Group
Visit Supplier
Sourced in United States

SR49059 is a laboratory equipment product. It is a device used for scientific research and analysis purposes. The core function of SR49059 is to facilitate specific laboratory operations and experiments. No further details about its intended use or performance characteristics are provided.

Automatically generated - may contain errors

Lab products found in correlation

Hexamethonium, by Merck Group (2 mentions) Vasopressin, by Merck Group (1 mentions) Neutral red, by Merck Group (1 mentions) Arginine vasopressin avp, by Merck Group (1 mentions) Isoproterenol, by Merck Group (1 mentions) 5 amp, by Merck Group (1 mentions) Cremophor rh40, by Merck Group (1 mentions) 3 3 5 5 tetramethylbenzidine (tmb), by Merck Group (1 mentions) Kt5720, by Merck Group (1 mentions) Hexadecyltrimethylammonium bromide htab, by Merck Group (1 mentions) Ly294002, by Merck Group (1 mentions) Losartan, by Merck Group (1 mentions) Ela 21, by Phoenix Pharmaceuticals (1 mentions) Mk 2206, by Selleck Chemicals (1 mentions)

8 protocols using sr49059

1

Competitive V1a Receptor Antagonist in Cerebral Ischemia

Check if the same lab product or an alternative is used in the 5 most similar protocols
SR49059 (Sigma-Aldrich, St Louis, MO, USA), the most potent nonpeptide competitive V1aR antagonist,31 (link) was initially dissolved in dimethyl sulphoxide at a concentration of 30 mM, and then diluted with 0.9% NaCl to 0.3 mM as a finial concentration. The drug application timeline was shown in Supplementary Figure S1. Since the 15th day after 2VO surgery, the 2VO + HTS group was given 5.3% NaCl (refs 32 (link), 33 (link)) as a single intraperitoneal injection of 2% bodyweight, 1 h before the Morris water maze (MWM) or LTP every day.32 (link), 34 (link) The 2VO + HTS + SR49059 group was given 0.3 mg kg−1 (1.67 ml kg−1, 0.3 mM) SR49059 (refs 35 , 36 (link)) intraventrally through the tail vein at 30 min following injection of 5.3% NaCl as described above, and the sham and 2VO groups received 0.9% NaCl as control. Water bottles were removed at the moment of first injection for all groups until 10 min before MWM and LTP.
Yang C., Zhang X., Gao J., Wang M, & Yang Z. (2017). Arginine vasopressin ameliorates spatial learning impairments in chronic cerebral hypoperfusion via V1a receptor and autophagy signaling partially. Translational Psychiatry, 7(7), e1174-.
+ Open protocol
+ Expand
2

Vasopressin and SR49059 Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols
Vasopressin and SR49059 were obtained from Sigma-Aldrich and dissolved in ultrapure distilled water on the day of the study.
Sellke N., Kuczmarski A., Lawandy I., Cole V.L., Ehsan A., Singh A.K., Liu Y., Sellke F.W, & Feng J. (2018). Enhanced Coronary Arteriolar Contraction to Vasopressin in Patients with Diabetes after Cardiac Surgery. The Journal of thoracic and cardiovascular surgery, 156(6), 2098-2107.
+ Open protocol
+ Expand
3

Avian Chick Photoperiod Experiment

Check if the same lab product or an alternative is used in the 5 most similar protocols
One-day old male chicks (Cobb 500) were obtained from a commercial hatchery and raised in an environmentally controlled room and fed a standard starter diet ad libitum. Birds were maintained on continuous light (L) with no dark (D) periods (LD 24:0) for 3 days, and then moved to a long-day photoperiod of LD 16:8. The selected mammalian V1bR antagonists (SSR- 149415, Manning compound, L-368899) and V1aR antagonist (SR-49059) were purchased from Sigma-Aldrich (St. Louis, MO, USA), and AVT and CRH were purchased from Bachem Americas Inc. (Torrance, CA, USA).
Kang S.W., Jayanthi S., Nagarajan G., Kumar T.K, & Kuenzel W.J. (2018). Identification of avian vasotocin receptor subtype-specific antagonists involved in the stress response of the chicken, Gallus gallus. Journal of biomolecular structure & dynamics, 37(7), 1685-1699.
+ Open protocol
+ Expand
4

Arginine Vasopressin Antagonist Study

Check if the same lab product or an alternative is used in the 5 most similar protocols
Arginine vasopressin (AVP), SR49059, neutral red, and Hexamethonium were purchased from Sigma, USA, and chloral hydrate and NaCl were purchased from Tiancheng, Chemical Ltd., China. All chemicals were in technical grade of more than 95% purity. All drugs were dissolved in normal saline (NS) and prepared immediately before use.
Zhu J., Chang L., Xie J, & Ai H. (2015). Arginine Vasopressin Injected into the Dorsal Motor Nucleus of the Vagus Inhibits Gastric Motility in Rats. Gastroenterology Research and Practice, 2016, 4618672.
+ Open protocol
+ Expand
5

Peptide and Pharmacological Compounds Procurement

Check if the same lab product or an alternative is used in the 5 most similar protocols
MTII and alpha-MSH were purchased from Bachem (Torrence, CA, USA). 5′-AMP, 8-cyclopentyl-1,3-dimethylxanthine (CPT), isoproterenol (Iso), and SR49059 (SR) were purchased from Sigma (St. Louis, MO, USA).
Xu Y., Kim E.R., Fan S., Xia Y., Xu Y., Huang C, & Tong Q. (2014). Profound and Rapid Reduction in Body Temperature Induced by the Melanocortin Receptor Agonists. Biochemical and biophysical research communications, 451(2), 184-189.
+ Open protocol
+ Expand
6

Comparative Evaluation of Vasopressor Agents

Check if the same lab product or an alternative is used in the 5 most similar protocols
SR-49059 (Relcovaptan) is a selective nonpeptidic V1a receptor antagonist. It was obtained from Sanofi-Aventis (Sanofi-Aventis, Toulouse, France). SR-49059 was dissolved in DMSO (48 mg/mL) then extemporaneously emulsified in Cremophor® RH40 (Sigma-Aldrich, Saint-Quentin-Fallavier, France) and diluted in 9% sodium chloride solution before injection. Treatment consisted of three intraperitoneal injections of SR-49059 solution performed, 1 h before anesthesia (4.5 mg/kg), 8 h after the surgery (6 mg/kg) and 1 h before sacrifice (4.5 mg/kg).
Terlipressin is a well-documented vasopressin receptor agonist inducing intense and prolonged vasoconstriction. Commercial terlipressin, Glypressine®, was obtained from Ferring GmbH (Kiel, Germany). Its purity has been previously evaluated by mass spectrometry [30 (link)]. Terlipressin solution (20 µg/mL) was prepared by solubilization in 9% sodium chloride. Treatment consisted of three intraperitoneal injections of terlipressin solution performed 1, 12 and 23 h after surgery and corresponding to a total dose of 80 µg/kg/24 h. To reduce the risk of bleeding due to the increase of blood pressure, terlipressin was not administered either preoperatively or immediately after surgery.
Gaudard P., David H., Bideaux P., Sicard P., Cristol J.P., Guillon G., Richard S., Colson P, & Virsolvy A. (2023). Involvement of Vasopressin in Tissue Hypoperfusion during Cardiogenic Shock Complicating Acute Myocardial Infarction in Rats. International Journal of Molecular Sciences, 24(2), 1325.
+ Open protocol
+ Expand
7

Murine Allergic Inflammation Modulation

Check if the same lab product or an alternative is used in the 5 most similar protocols
Six to eight-week-old female mice (BALB/c, 20-24 g) obtained from Shanghai Experimental Animal Center (Shanghai, China) were given standard diet and water. All the experimental protocols were approved by the Animal Ethics Committee of Shanghai Jiao Tong University. Rhodamine (X-rhodamine-5-(and-6)isothiocyanate), ovalbumin (OVA, Grade V), SR-49059 (V1A antagonist), SR-121463A (V2 antagonist), KT-5720 (PKA inhibitor), Go-7874 (PKC inhibitor), hexadecyltrimethylammonium bromide (HTAB), and 3, 3', 5, 5'-tetramethylbenzidine (TMB) were collected from Sigma-Aldrich (St Louis, MO). Southern Biotech (Birmingham,USA) provided HRP labelled anti-mouse IgE secondary. ELISA kits of IL-6, IL-10, and IFN-γ were supplied from Biolegend (San Diego, CA)
Hou L., Zhu L., Zhang M., Zhang X., Zhang G., Liu Z., Li Q, & Zhou X. (2017). Participation of Antidiuretic Hormone (ADH) in Asthma Exacerbations Induced by Psychological Stress via PKA/PKC Signal Pathway in Airway-Related Vagal Preganglionic Neurons (AVPNs). Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 41(6).
+ Open protocol
+ Expand
8

Pharmacological Agents for Research

Check if the same lab product or an alternative is used in the 5 most similar protocols
ELA-21 and F13A were obtained from Phoenix Pharmaceuticals (Belmont, CA). Hexamethonium, SR49059, losartan, and LY294002 were purchased from Sigma Chemical (St. Louis, MO). MK-2206 was obtained from Selleck Chemicals (Houston, TX).
Geng Z., Ye C., Tong Y., Zhang F., Zhou Y.B, & Xiong X.Q. (2020). Exacerbated pressor and sympathoexcitatory effects of central Elabela in spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology, 318(1).
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!