Starting 3 days prior to the operation, the animals received daily antiaggregant treatment (sheep: oral acetylsalicylic acid, Bayer; minipig: Clopidogrel, Sanofi) to prevent thrombosis. Twenty hours before surgery the animals were weighed and Enrofloxacin (5% Baytril®, Bayer) and/or Amoxicillin (Duphamox® LA, Zoetis) were administered. After anesthesia was induced, heparin (Heparin Choay®, Sanofi) was injected into the femoral artery via an introducer sheath and Activated Clotted Time (ACT) was evaluated using a Hemochron Junior 2 (International Technidyne Corp., USA) instrument. Analgesic, anti-inflammatory drugs and antibiotic treatments were administered during surgery and the follow up period. Animals were also maintained under prophylactic anticoagulant/antiaggregant therapy for the 4 weeks of observation until termination.
Duphamox la
Manufactured by Zoetis
Duphamox LA is a veterinary pharmaceutical product containing the active ingredient amoxicillin. It is a long-acting formulation designed for intramuscular injection in animals.
Automatically generated - may contain errors
Lab products found in correlation
Heparin choay, by Sanofi (1 mentions)
Baytril, by Bayer (1 mentions)
Clopidogrel, by Sanofi (1 mentions)
Oxytetrin spray, by MSD (1 mentions)
Vetedine solution, by Vetoquinol (1 mentions)
Baytril 10, by Bayer (1 mentions)
Propovet, by Zoetis (1 mentions)
Ringer lactate, by Baxter (1 mentions)
Isoflo, by Zoetis (1 mentions)
Rimadyl, by Zoetis (1 mentions)
4 protocols using duphamox la
1
Antithrombotic Therapy in Animal Studies
2
Postoperative Treatment Protocol in Animals
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
An IM injection of buprenorphine (Buprecare®, Axience, 0.005 mg/kg) was administered at the end of the surgery day, then daily for 2 days post‐surgery. An anti‐inflammatory drug (flunixin, Meflosyl® Injectable, Zoetis, 2 mg/kg) was administered IM daily for 7 days post‐surgery and antibiotics were given for 3 weeks following surgery: amoxicillin (Duphamox LA®, Zoetis, IM, once every 2 days, 15 mg/kg) and enrofloxacin (Baytril® 10%, Bayer Pharma, subcutaneous daily, 5 mg/kg). After approximately 2 weeks following surgery, the surgical sutures and staples were removed. The wounds were disinfected with oxytetracycline (Oxytetrin® spray, MSD) once every 2 days until 2 days after the removal of the surgical sutures and staples. When needed, the local disinfection was replaced/extended with povidone iodine (Vetedine® solution, Vetoquinol).
3
Postoperative Care for Sheep
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The sheep were left to recover from the anaesthesia in the operating room and returned to their individual cages and kept under close observation. An intramuscular injection of buprenorphine was administered at the end of the surgery day, then daily for 2 days postsurgery. An anti-inflammatory drug (flunixine) was administered daily for 5 days postsurgery and an antibiotic (amoxicillin, Duphamox LA, Zoetis, long action) was given every other day for 8 days following surgery. The surgical staples were removed after complete healing (2 weeks following surgery). The wounds were disinfected with oxytetracycline (Oxytetrin spray, Intervet) every other day until 2 days after the removal of the surgical staples. After this period of recovery, the sheep returned to a farm setting.
4
Sheep Surgical Anesthesia and Monitoring
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
On the day of surgery, pre-medication was performed by intravenous injection of a mixture of diazepam (Diazepam ® , TVM) and butorphanol (Torphasol ® , Axience). Anesthesia was induced by intravenous injection of propofol (Propovet ® , Zoetis). Each sheep was intubated, mechanically ventilated, and placed on isoflurane inhalant anesthetic (IsoFlo ® , Zoetis) for continued general anesthesia. A suitable electrolyte solution (Ringer lactate, Baxter) was administered via intravenous infusion during surgery. An anti-inflammatory drug (carprofen, Rimadyl ® , Zoetis, subcutaneous) and a prophylactic antibiotic treatment (amoxicillin, Duphamox LA ® , Zoetis, intramuscular) were administered via pre-operative injection. The surgical areas were clipped free of wool, scrubbed with povidone iodine (Vetedine savon ® , Vetoquinol), wiped with 70% isopropyl alcohol (Savetis), painted with povidone iodine solution (Vetedine solution ® , Vetoquinol), and draped. The sheep were placed in the supine position on a warmed pad. A rectal temperature probe and a rumen tube were inserted during surgery. Electrocardiogram (ECG), peripheral non-invasive arterial blood pressure, and oxygen saturation were monitored.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!