Cyclopentolate

Manufactured by Bausch & Lomb

Sourced in United States

Cyclopentolate is a topical ophthalmic agent used in medical and research settings. It acts as a cycloplegic, temporarily paralyzing the ciliary muscle of the eye, and as a mydriatic, dilating the pupil. This product is primarily used for diagnostic purposes, such as refractive assessments and eye examinations.

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Lab products found in correlation

Tropicamide, by Akorn (1 mentions) Ketamine, by Henry Schein (1 mentions) Xylazine, by Henry Schein (1 mentions) Tropicamide, by Bausch & Lomb (1 mentions) Phenylephrine hydrochloride, by Akorn (1 mentions) Proparacaine hydrochloride, by Akorn (1 mentions)

Spelling variants of this product

Cyclopentolate hydrochloride (6 citations) Cyclopentolate hydrochloride 1% (4 citations)

3 protocols using cyclopentolate

Pupillary Dilation Protocol for Eye Research

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Pupillary dilation was performed with 1 drop of 1% cyclopentolate (Bausch & Lomb, Inc), followed by 1 drop of 1% tropicamide (Akorn, Inc), and finally 1 drop of 2.5% phenylephrine (Paragaron BioTeck, Inc). Eye-drop administration order was standardized as beginning with the right eye for each drop, regardless of which eye was randomized to receive eye drops via the Nanodropper. For eyes randomized to the small-volume eye dropper, the Nanodropper adaptor was secured on eye-drop bottles (Fig 2).

Hoppe C.B., Yonamine S., Kao B.W., Turner M.L., Ou Y., Han Y., Keenan J.D, & Oatts J.T. (2022). Randomized Trial to Evaluate the Efficacy of the Nanodropper Device for Pupillary Dilation and Cycloplegia in Children. Ophthalmology, 130(3), 324-330.

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Intravitreal and Subretinal Injection Protocols

Cited 1 time

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Intravitreal and subretinal injections were performed as previously described [9 (link),24 (link),25 (link)]. Within the sterile surgical room, adult Balb/c mice were anesthetized by an intraperitoneal injection of 85 mg/kg ketamine and 14 mg/kg xylazine (Henry Schein Animal Health, Dublin, OH, USA). Eyes were dilated with 1% cyclopentolate (Bausch and Lomb, Rochester, NY, USA). For intravitreal injections, a very shallow puncture was made through the sclera in the dorsal hemisphere using a beveled 30-gauge needle (BD Biosciences, Franklin Lakes, NJ, USA). Through this puncture, a 33-gauge blunt-end needle was introduced into the vitreous cavity and 1.5–3 µL of material (nanospheres, saline, LPS, ST, or ST/HA-NS mixture) was injected into the vitreous space near optic nerve using a 5 µL microinjection Syringe (Hamilton, Reno, NV, USA). For subretinal injections, the needle was then advanced gently through the retina and into the subretinal space, where the nanosphere suspension was gently delivered. Visualization of a subretinal bleb during injection and subsequent fundoscopic and OCT imaging confirmed successful subretinal delivery. Triple antibiotic ointment (Taro Pharmaceuticals, Inc., Hawthorne, NY, USA) was applied to each eye after injection.

Eblimit A., Makia M.S., Strayve D., Crane R., Conley S.M., Sinha T., Acharya G., Al-Ubaidi M.R, & Naash M.I. (2021). Co-Injection of Sulfotyrosine Facilitates Retinal Uptake of Hyaluronic Acid Nanospheres Following Intravitreal Injection. Pharmaceutics, 13(9), 1510.

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Dark-Adapted Electroretinography in Mice

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P24 or adult 6 week old mice were dark-adapted overnight and then anesthetized using ketamine (40mg/kg) and xylazine (8mg/kg). Pupils were dilated using 1% tropicamide (Bausch and Lomb, Tampa, FL, USA), 2.5% phenylephrine hydrochloride (Akorn Inc., Lake Forest, IL, USA), and 1% cyclopentolate (Bausch and Lomb). Eyes were anesthetized with 0.5% proparacaine hydrochloride (Akorn, Inc.). Mice were placed on a temperature regulated heating pad and ERGs were recorded using an Espion E3 ColorDome Full field Ganzfeld (Diagnosys, LLC, Lowell, MA, USA) as described previously (Ng et al., 2010 (link)). Details about rod (scotopic) and wavelength specific photopic responses are mentioned in supplemental experimental procedures.

Sawant O.B., Horton A.M., Zucaro O.F., Chan R., Bonilha V.L., Samuels I.S, & Rao S. (2017). The circadian clock gene Bmal1 controls thyroid hormone-mediated spectral identity and cone photoreceptor function. Cell reports, 21(3), 692-706.

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