We randomly divided C57BL/6 female WT or P2rx4−/− mice into four groups: Control, DSS, DSS+2 mg IVM and DSS+5 mg IVM. Except for regular water in the Control group, mice in the other three groups drank 3% DSS solution continuously for 6 days, then replaced with regular water, and sacrificed mice on the 7th day. Ivermectin (Cat No HY‐15310; MedChemExpress LLC, Shanghai, China) was dissolved in 1% carboxymethyl cellulose sodium (Cat No C304951; Aladdin, Shanghai, China). Mice were administrated with Ivermectin orally once a day at doses of 0, 2 or 5 mg/kg body weight from day 0 to day 6 (Figure 9A ).
Ivermectin
Manufactured by MedChemExpress
Sourced in China
Ivermectin is a chemical compound commonly used in veterinary and human medicine. It functions as an antiparasitic agent, targeting and disrupting the nervous system of various parasites. The core purpose of ivermectin is to eliminate or control parasitic infestations.
Automatically generated - may contain errors
2 protocols using ivermectin
1
Investigating Ivermectin's Role in DSS-Induced Colitis
2
Preparation and Characterization of Aggregated IgG
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Antibodies used were listed in Suppl. Table 2 . Fludarabine monophosphate (TCI Chemicals) and ivermectin (MedChemExpress) were freshly prepared by dissolving in DMSO at high concentrations and further diluted in saline (5% DMSO) for injection. Clodronate liposomes and PBS liposomes were obtained from Yeasen. Recombinant IFN-γ was purchased from PeproTech. Aggregated IgG (AIgG) was prepared by heating mouse serum IgG (Sigma) at 62 °C for 30 min and centrifuging at 18000 × g for 20 min.
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