2-[18F]FDG PET images were acquired at the Department of Nuclear Medicine, UMCL with Siemens Biograph mCT PET/CT (Siemens Healthineers, Erlangen, Germany) according to European Association of Nuclear Medicine (EANM) guidelines (Varrone et al., 2009 (link)) as described previously (Tomše et al., 2017 (link)).
DaTSCAN™ was performed at the Department of Nuclear Medicine, UMCL, using a Siemens Symbia Intevo SPECT/CT system (Siemens Healthineers, Munich, Germany) using [123I]I-ioflupane ([123I]I-FP-CIT), following EANM recommendations (Darcourt et al., 2010 (link)). To minimize thyroid exposure to radiation, all patients received 90 mg of iodide (KI p.o.) 1 h prior to i.v. administration of 185 MBq of [123I]I-FP-CIT. SPECT images were acquired 4 h after the radiotracer application, using a LEHR collimator, with a photopeak of 159 KeV ± 15%, using a circular orbit in step-and-shoot mode (60 steps of 25 s) over 360°, with a 128 × 128 matrix, using a zoom of 1.78. Images were reconstructed using the Flash-3D iterative algorithm (2 iterations, 15 subsets), using scatter correction, a 3D Gaussian filter (FWHM = 6 mm) and AC correction using the Chang algorithm (μ = 0,12 cm−1).
DaTSCAN™ was performed at the Department of Nuclear Medicine, UMCL, using a Siemens Symbia Intevo SPECT/CT system (Siemens Healthineers, Munich, Germany) using [123I]I-ioflupane ([123I]I-FP-CIT), following EANM recommendations (Darcourt et al., 2010 (link)). To minimize thyroid exposure to radiation, all patients received 90 mg of iodide (KI p.o.) 1 h prior to i.v. administration of 185 MBq of [123I]I-FP-CIT. SPECT images were acquired 4 h after the radiotracer application, using a LEHR collimator, with a photopeak of 159 KeV ± 15%, using a circular orbit in step-and-shoot mode (60 steps of 25 s) over 360°, with a 128 × 128 matrix, using a zoom of 1.78. Images were reconstructed using the Flash-3D iterative algorithm (2 iterations, 15 subsets), using scatter correction, a 3D Gaussian filter (FWHM = 6 mm) and AC correction using the Chang algorithm (μ = 0,12 cm−1).