Cinnamic acid

Manufactured by Merck Group

Sourced in United States, Germany, United Kingdom, China, Italy, Portugal, Switzerland, India, Sao Tome and Principe

Cinnamic acid is a naturally occurring organic compound. It is a white crystalline solid with a sweet, aromatic odor. Cinnamic acid is commonly used as a starting material in the synthesis of various organic compounds and as a chemical building block in the pharmaceutical and cosmetic industries.

Automatically generated - may contain errors

Lab products found in correlation

176 protocols using cinnamic acid

HPLC Analysis of Phenolic Compounds in Melon

Check if the same lab product or an alternative is used in the 5 most similar protocols

Analyses of phenolic compounds in melon pulp extract were performed using a high‐performance liquid chromatography (HPLC) (Hewlett‐Packard System) system equipped with a HP‐1100 pump, a Rheodyne model 7725 injector (Cotati, CA, USA, loop volume 20 μl), a UV detector (280 nm), and a C₁₈ Technochrom Eurosphere 100 analytical column (250 mm × 8 mm). An aliquot of 3 ml of Maazoun flesh extract was filtered using a 0.45‐μm membrane filter before injection. The HPLC separation was running for a total time of 24 min and the flow rate was maintained at 0.50 ml/min. The mobile phases for chromatographic analysis were: (A) acetonitrile and (B) sulfuric acid/water (2:98). A linear gradient was run from 15% (A) and 85% (B) to 40% (A) and 60% (B) during 12 min; it changed to 60% (A) and 40% (B) in 2 min; after 4 min, it changed to 80% (A) and 20% (B); and then to 90% (A) and 10% (B) after 2 min; it becomes 100% (A) during 4 min. The data were stored and processed by HPLC ChemStation (DOS Series) (Hewlett‐Packard). Cinnamic acid (purchased from Sigma‐Aldrich) was used as internal standard for the quantification of phenolic compounds and the results were expressed as milligrams of Cinnamic acid per 100 g of flesh and as percentages.

Mallek‐Ayadi S., Bahloul N., Baklouti S, & Kechaou N. (2022). Bioactive compounds from Cucumis melo L. fruits as potential nutraceutical food ingredients and juice processing using membrane technology. Food Science & Nutrition, 10(9), 2922-2934.

+ Open protocol

+ Expand

Lovastatin Purification and Quantification

Check if the same lab product or an alternative is used in the 5 most similar protocols

The lovastatin (LOV) raw material was purchased from Valdequimica, Brazil (purity reported to be >99%) and used without further purification. Adipic acid (ADI, 99% purity), citric acid (CIT, 99% purity), and tartaric acid (TAR, 99% purity) were acquired from Fischer Scientific (Hampton, NH, USA). Benzoic acid (BEN, 99% purity), salicylic acid (SAL, 99% purity) and cinnamic acid (CIN, 99% purity) were purchased from Merck (Darmstadt, Hesse, Germany), Mallinckrodt (Phillipsburg, NY, USA) and Sigma-Aldrich (Saint Louis, MO, USA), respectively. Lovastatin pharmaceutical secondary standard traceable to USP and PhEur Fluka brand used in the HPLC quantification studies was purchased from Sigma-Aldrich. All solvents were HPLC/UV grade, and water was purified using a Millipore system filtered through a Millipore 0.22 µm Millipak™ 40 membrane.

Araya-Sibaja A.M., Vega-Baudrit J.R., Guillén-Girón T., Navarro-Hoyos M, & Cuffini S.L. (2019). Drug Solubility Enhancement through the Preparation of Multicomponent Organic Materials: Eutectics of Lovastatin with Carboxylic Acids. Pharmaceutics, 11(3), 112.

+ Open protocol

+ Expand

Synthesis and Characterization of Titanium-based Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols

Tetraisopropyl titanate
(Ti(OC₃H₇)₄, Merck, 97.0%), hydrochloric
acid (HCl,
Prolabo, 98.0%), sodium chloride (NaCl, Merck, 99.0%), sodium hydroxide
1.0 N solution (NaOH, Pharmacopoeia Europaea), cinnamic acid (C₉H₈O₂, Merck, 97.0%), ethanol (C₂H₅OH, Merck, 99.5%), citric acid monohydrate (C₆H₈O₇·H₂O, Merck, 99.0%),
and cobalt(II) nitrate hexahydrate (Co(NO₃)₂·6H₂O, Merck, 97.0%) were used in this investigation.

Ha C.A., Nguyen D.T, & Nguyen T. (2022). Green Fabrication of Heterostructured CoTiO3/TiO2 Nanocatalysts for Efficient Photocatalytic Degradation of Cinnamic Acid. ACS Omega, 7(44), 40163-40175.

+ Open protocol

+ Expand

Phenolic Standards Characterization Protocol

Check if the same lab product or an alternative is used in the 5 most similar protocols

Phenolic standards, namely, catechin, catechol, syringic acid, chlorogenic acid, cinnamic acid, ellagic acid, kaempferol, ferulic acid, gallic acid, rutin, caffeic acid, naringenin, benzoic acid, o-coumaric acid, p-hydroxybenzoic acid, pyrogallol, p-coumaric acid, quercetin, quinol, rosmarinic acid, and vanillic acid were bought from Merck KGaA (Darmstadt, Germany). The purities of standards were up to 99%. The solvents used were of analytical grade, dimethylsulfoxide (DMSO; Alfa Aesar GmbH & Co KG, Massachusetts, United States), orthophosphoric acid (H₃PO₄), ethanol, methanol, and acetonitrile HPLC-grade (Fisher Scientific International, Inc., Hampton, New Hampshire, United States).

Behiry S.I., Al-Askar A.A., Soliman S.A., Alotibi F.O., Basile A., Abdelkhalek A., Elsharkawy M.M., Salem M.Z., Hafez E.E, & Heflish A.A. (2022). Plantago lagopus extract as a green fungicide induces systemic resistance against Rhizoctonia root rot disease in tomato plants. Frontiers in Plant Science, 13, 966929.

+ Open protocol

+ Expand

Synthesis and Characterization of Inorganic Compounds

Check if the same lab product or an alternative is used in the 5 most similar protocols

All the chemicals used, including inorganic salts such as bismuth (III) nitrate pentahydrate (BiNO₃.5H₂O), iron (III) nitrate nanohydrate (FeNO₃.9H₂O), phosphoric acid(H₃PO₄), and sodium hydroxide (NaOH); and organic compounds such as methanol, succinic acid, cinnamic acid, lactose, and maltose, were of analytical grade (purity > 99.99%), and were purchased from Merck. Cefixime trihydrate was obtained from Pharmagen limited Lahore (Pakistan) and used without further purification.

Nazir A., Latif S., Adil S.F., Kuniyil M., Imran M., Hatshan M.R., Kanwal F, & Shaik B. (2021). Photocatalytic Degradation of Cefixime Trihydrate by Bismuth Ferrite Nanoparticles. Materials, 15(1), 213.

+ Open protocol

+ Expand

Phytochemical Properties and Characterization

Check if the same lab product or an alternative is used in the 5 most similar protocols

Trans-cinnamaldehyde, sabinene hydrate, eugenol and terpineol (Table 1) were obtained from Sigma-Aldrich (Lisbon, Portugal); cinnamic acid was obtained from Merck (Lisbon, Portugal); citronellol was obtained from Acros Organics (Morris, NJ, USA). The structural and molecular properties of selected phytochemicals were determined with Molinspiration Calculation Software and Chemdraw (Malheiro et al., 2016 (link)). The phytochemicals were dissolved in dimethyl sulfoxide (DMSO, Sigma-Aldrich, St. Louis, MO, USA). Each compound was tested at various concentrations in the range of 1–25 mM in DMSO.

Ribeiro M., Malheiro J., Grenho L., Fernandes M.H, & Simões M. (2018). Cytotoxicity and antimicrobial action of selected phytochemicals against planktonic and sessile Streptococcus mutans. PeerJ, 6, e4872.

+ Open protocol

+ Expand

Antioxidant and Analytical Reagents

Check if the same lab product or an alternative is used in the 5 most similar protocols

2,20-Diphenyl-1-picrylhydrazyl (DPPH), 2,20-azobis (2-amidinopropane), gallic acid dihydrochloride (AAPH), L-ascorbic acid, trichloro acetic acid (TCA), 1,1,3,3-tetraethoxypropane (TEP), thiobarbituric acid (TBA), and butylated hydroxytoluene (BHT) were purchased from Sigma (St. Lois, MO, USA). Folin-Ciocalteu phenol reagent was obtained from Fluka. Standards (gallic acid, cinnamic acid, rutin) were obtained from Merck Life Science (Merck KGaA, Darmstadt, Germany). LC-MS grade methanol, acetonitrile, acetic acid, acetone, and water were purchased from Merck Life Science (Merck KGaA, Darmstadt, Germany). All other chemicals were of analytical grade and obtained from Sigma (St. Louis, MO, USA).

Cadi H.E., Bouzidi H.E., Selama G., Cadi A.E., Ramdan B., Oulad El Majdoub Y., Alibrando F., Dugo P., Mondello L., Fakih Lanjri A., Brigui J, & Cacciola F. (2020). Physico-Chemical and Phytochemical Characterization of Moroccan Wild Jujube “Zizyphus lotus (L.)” Fruit Crude Extract and Fractions. Molecules, 25(22), 5237.

+ Open protocol

+ Expand

Cinnamic Acid Compound Procurement

Check if the same lab product or an alternative is used in the 5 most similar protocols

Cinnamic acid and methyl trans-cinnamate were purchased from Merck (VWR, Portugal). CTAB, cinnamyl alcohol, hydroCinnamic acid, α-methylhydroCinnamic acid, and α-methylCinnamic acid were purchased from Acros Organics (Portugal). LA, cinnamaldehyde, allyl cinnamate, and α-fluoroCinnamic acid were purchased from Sigma (Portugal). Cinnamamide was purchased from Alfa Aesar (VWR; Portugal). The CAS number of each chemical is provided in Table 2.

Malheiro J.F., Maillard J.Y., Borges F, & Simões M. (2019). Biocide Potentiation Using Cinnamic Phytochemicals and Derivatives. Molecules, 24(21), 3918.

+ Open protocol

+ Expand

Synthesis and Solubilization of Phytochemicals

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

Chalcone (Sigma-Aldrich, St. Louis, MO, USA), juglone (Sigma-Aldrich, St. Louis, MO, USA), cinnamic acid (Merck, Darmstadt, Germany), trigonelline (Sigma-Aldrich, St. Louis, MO, USA), guaiazulene (Sigma-Aldrich, St. Louis, MO, USA), α-bisabolol (Sigma-Aldrich, St. Louis, MO, USA), farnesol (Sigma-Aldrich, St. Louis, MO, USA) and nerolidol (Sigma-Aldrich, St. Louis, MO, USA) were purchased as pure compounds. Furvina and 2-nitrovinylfuran derivatives 1–4 were synthesized as previously described [19 (link),39 (link)]. Stock solutions of trigonelline were prepared in sterile distilled water, whereas for the remaining molecules, dimethyl sulfoxide (DMSO, 100%) was used as the solvent. For phytochemical-based molecules, serial dilutions from 1000 mg/L to 6.25 mg/L were prepared when needed. The percentage of DMSO never exceeded 10% (v/v) of the final volume.

Oliveira D., Borges A., Saavedra M.J., Borges F, & Simões M. (2022). Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections. Antibiotics, 11(5), 620.

+ Open protocol

+ Expand

Quantifying Antioxidant Compounds in Samples

Check if the same lab product or an alternative is used in the 5 most similar protocols

Folin-Ciocalteu phenol reagent was obtained from Fluka. Standards (gallic acid, caffeic acid, cinnamic acid, ferulic acid, coumarin, rutin and kaempferol) were obtained from Merck Life Science (Merck KGaA, Darmstadt, Germany). In addition, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and butylated hydroxytoluene (BHT) were purchased from Sigma (St. Louis, MO, USA). LC-MS grade methanol, acetonitrile, acetic acid, EtOAc, acetone and water were purchased from Merck Life Science (Merck KGaA, Darmstadt, Germany). All of the other chemicals were of analytical grade and obtained from Sigma (St. Louis, MO, USA).

Cadi H.E., Bouzidi H.E., Selama G., Ramdan B., Majdoub Y.O., Alibrando F., Arena K., Lovillo M.P., Brigui J., Mondello L., Cacciola F, & Salerno T.M. (2021). Elucidation of Antioxidant Compounds in Moroccan Chamaerops humilis L. Fruits by GC–MS and HPLC–MS Techniques. Molecules, 26(9), 2710.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!