Thiomyristoyl

Manufactured by Selleck Chemicals

Sourced in United States

Thiomyristoyl is a laboratory chemical used as a reagent in various chemical reactions and analytical procedures. It is a myristic acid derivative with a thiol (sulfhydryl) functional group. Thiomyristoyl is commonly used in organic synthesis, biochemistry, and materials science applications.

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Lab products found in correlation

Human pan t cell isolation kit, by Miltenyi Biotec (1 mentions) Ficoll paque plus media, by GE Healthcare (1 mentions) Doxorubicin hydrochloride, by Merck Group (1 mentions) Selisistat, by Selleck Chemicals (1 mentions) Vrk in 1, by MedChemExpress (1 mentions) Mg149, by Axon Medchem (1 mentions)

2 protocols using thiomyristoyl

CD3+ T cell activation and inhibition

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Human PBMC were obtained from healthy donors (OneBlood) by density
gradient centrifugation using Ficoll-Paque™ PLUS Media (GE
Healthcare). CD3⁺ T cells were negatively enriched using a human
Pan T cell isolation kit™ (Miltenyi Biotec). Enriched CD3⁺T cells were cultured in complete RPMI medium and activated with anti-CD3
antibody coated plate (5 μg/ml, OKT-3, BioXCell) in the presence of
DMSO (vehicle) or the indicated concentrations of AGK2 and Thiomyristoyl
(Selleck Chemicals).

Hamaidi I., Zhang L., Kim N., Wang M.H., Iclozan C., Fang B., Liu M., Koomen J.M., Berglund A.E., Yoder S.J., Yao J., Engelman R.W., Creelan B.C., Conejo-Garcia J.R., Antonia S.J., Mulé J.J, & Kim S. (2020). Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T cells. Cell metabolism, 32(3), 420-436.e12.

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Compound Treatment Protocols for Research

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AGK2, AK7, thiomyristoyl and selisistat were purchased from Selleckchem (Houston, TX, USA); MG149 from Axon MedChem (Groningen, The Netherlands); doxorubicin hydrochloride from Sigma-Aldrich (St. Louis, MO, USA); and VRK-IN1 from MedChemExpress (Monmouth Junction, NJ, USA). Cells were treated following the indicated schemes (Table 1).

Monte-Serrano E, & Lazo P.A. (2023). VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1. International Journal of Molecular Sciences, 24(5), 4912.

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