N methylmorpholine nmm

Manufactured by Gyros Protein Technologies

Sourced in United States

N-methylmorpholine (NMM) is a chemical compound used as a solvent and reagent in various laboratory applications. It is a colorless liquid with a characteristic amine-like odor. NMM is commonly employed in organic synthesis reactions, particularly in the preparation of pharmaceuticals and other fine chemicals.

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2 protocols using n methylmorpholine nmm

Synthesis and Characterization of Peptide-Drug Conjugates

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2(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate (HBTU) and the N-hydroxybenzotriazole (HOBt) were purchased from Vivitide. All protected amino acids, rink amide MBHA resin, and N-methylmorpholine (NMM) were supplied by Gyros Protein Technologies. Polyethylene glycol (PEG₃) was obtained from Creative PEGWorks. Trifluoroacetic acid (TFA), piperidine, thio anisole, anisole, 1,2-ethanedithiole, methyl-tert-butyl ether, N,N-diisopropylethylamine (DIPEA), dimethylformamide (DMF), acetonitrile (ACN), N-methyl-2-pyrrolidone (NMP), sodium carbonate, Sephadex G25, L-glutathione reduced (GSH), lipopolysaccharide (LPS), and cis-dichlorodiammine platinum (II) (cisplatin) were purchased from Sigma-Aldrich. Succinimidyl 3-(2-pyridyldithio)propionate (SPDP) was supplied by Invitrogen. p-SNC-deferoxamine (DFO) was from Macrocyclics Inc. N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine (DM1) and aldoxorubicin HCl (aldox) were from MedKoo Biosciences. Doxorubicin (DOX) and GEM were obtained from LC Laboratories. MIT was supplied by Selleckchem. Cyanine5.5 NHS ester was purchased from Lumiprobe Corporation and luciferin was from Caliper LifeScience.

Bellat V., Michel A.O., Thomas C., Stokol T., Choi B.B, & Law B. (2022). A Urinary Drug-Disposing Approach as an Alternative to Intravesical Chemotherapy for Treating Nonmuscle Invasive Bladder Cancer. Cancer Research, 82(7), 1409-1422.

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Solid-Phase Peptide Synthesis of Cysteine-Containing Peptides

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A high-loading Rink amide methylbenzhydrylamine (MBHA) resin, Fmoc-L-Cys(Trt)-OH, Fmoc-L-Trp(Boc)-OH, Fmoc-L-Gln(Trt)-OH, Fmoc-L-Tyr(tBu)-OH, Fmoc-L-Leu-OH, Fmoc-L-His(Trt)-OH, Fmoc-L-Phe-OH, Fmoc-L-Lys(Boc)-OH, Fmoc-L-Val-OH, O-(1H-6-Chlorobenzotriazole-1-yl) (HCTU), and N-methyl morpholine (NMM) were purchased from Gyros Protein Technologies, Tucson, AZ, USA. Additionally, N, N-dimethylformamide (DMF), dichloromethane (DCM), acetonitrile, diethyl ether, acetic anhydride, saturated phenol, and ammonium bicarbonate were purchased from Fisher Scientific (Waltham, MA, USA). Piperidine, 2,6-lutidine, trifluoroacetic acid (TFA), and triisopropylsilane (TIPS) were purchased from Sigma-Aldrich (St. Louis, MI, USA).

Stephanie F., Saragih M., Tambunan U.S, & Siahaan T.J. (2022). Structural Design and Synthesis of Novel Cyclic Peptide Inhibitors Targeting Mycobacterium tuberculosis Transcription. Life, 12(9), 1333.

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