Transcutol hp

Manufactured by Gattefosse

Sourced in France, India, Germany, United States

Transcutol HP is a high-purity, pharmaceutical-grade solvent used in various formulations. It serves as a solubilizer, humectant, and penetration enhancer to facilitate the delivery of active ingredients through the skin.

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Lab products found in correlation

Labrasol, by Gattefosse (27 mentions) Capryol 90, by Gattefosse (22 mentions) Tween 80, by Merck Group (16 mentions) Labrafil m 1944 cs, by Gattefosse (12 mentions) Lauroglycol 90, by Gattefosse (11 mentions) Cremophor el, by BASF (10 mentions) Labrafil m 2125 cs, by Gattefosse (9 mentions) Tween 20, by Merck Group (9 mentions) Cremophor rh40, by BASF (8 mentions) Lauroglycol fcc, by Gattefosse (7 mentions) Peceol, by Gattefosse (7 mentions) Capryol pgmc, by Gattefosse (6 mentions) Labrafac pg, by Gattefosse (6 mentions) Gelucire 44 14, by Gattefosse (5 mentions) Cremophor el, by Merck Group (5 mentions) Isopropyl myristate, by Merck Group (5 mentions) Ethanol, by Merck Group (5 mentions) Peg400, by Merck Group (4 mentions) Castor oil, by Merck Group (4 mentions) Acetonitrile, by Merck Group (4 mentions)

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Transcutol (28 citations)

68 protocols using transcutol hp

Formulation and Characterization of Fenugreek SEDDS

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Isopropyl myristate was purchased from Merck (Darmstadt, Germany). Transcutol HP, Labrasol, Kolliphor RH40 and Capryol 90 were obtained from Gattefossé (Saint-Priest, France).
We formulated 5 different compositions of the liquid extract, the SEDDS excipients and PBS, as displayed on Table 3.
The various amounts of isopropyl miristate, Transcutol HP, Labrasol, Kolliphor RH40 and Capryol 90 were mixed well in a plastic tube. Concentrated liquid fenugreek extract or PBS was added, then the mixture was mixed with gentle vortexing until we achieved a visually homogenous appearance. All the experiments were performed immediately after preparation.

Sinka D., Doma E., Szendi N., Páll J., Kósa D., Pető Á., Fehér P., Ujhelyi Z., Fenyvesi F., Váradi J., Vecsernyés M., Szűcs Z., Gonda S., Cziáky Z., Kiss-Szikszai A., Vasas G, & Bácskay I. (2022). Formulation, Characterization and Permeability Studies of Fenugreek (Trigonella foenum-graecum) Containing Self-Emulsifying Drug Delivery System (SEDDS). Molecules, 27(9), 2846.

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Aloe Vera-Based Amphotericin B Topical Gel

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Amphotericin B was obtained as a gift from Bharat Serum and Vaccines Ltd., Thane, India; Capmul MCM (glyceryl mono-dicaprylate) was supplied by Abitech Corporation through Indchem International, Mumbai, India; Cremophore RH 40 (PEG 35 castor oil) was obtained from BASF India Ltd., Mumbai, India; and Transcutol HP (Highly purified diethylene glycol monoethyl ether) was obtained from Gattefosse, Lyon, France. The gelling agent, Carbopol® 974P, was a kind gift from Noveon, Inc. Cleveland, OH, USA. Aloe vera gel was purchased from D. Jain's Eco-friendly Industries, India. All other reagents used were of analytical grade.

Patil M.U., Rajput A.P., Belgamwar V.S, & Chalikwar S.S. (2022). Development and characterization of amphotericin B nanoemulsion-loaded mucoadhesive gel for treatment of vulvovaginal candidiasis. Heliyon, 8(11), e11489.

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Silymarin-based Nanoformulation Development

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Silymarin, silibinin, sulfatase, β-glucuronidase, narigenin, PEG 400, Cremophor^® RH40, Tween 20, and Nile red were purchased from Sigma-Aldrich (St Louis, MO, USA). The lot number for Silymarin was BCBJ0393V. The percentage of silibinin in Silymarin was 45.0% according to the certificate of analysis provided by the vendor. DAPI (4′,6-diamidino-2-phenylindole) was supplied by Invitrogen (Carlsbad, CA, USA). Capmul^® GMO-50 (glyceryl monooleate) was a gift from Abitec (Commerce, CA, USA). Transcutol^® HP (diethylene glycol monoethyl ether) was a gift from Gattefossé (Lyon, France).

Chen C.H., Chang C.C., Shih T.H., Aljuffali I.A., Yeh T.S, & Fang J.Y. (2015). Self-nanoemulsifying drug delivery systems ameliorate the oral delivery of silymarin in rats with Roux-en-Y gastric bypass surgery. International Journal of Nanomedicine, 10, 2403-2416.

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Formulation Development for Enhanced Salmon Calcitonin Delivery

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Sodium caprate (C 10 ) (PubChem CID: 4457968), citric acid (CA) (CID: 311), and sodium taurodeoxycholate (NaTDC) (CID: 56840807), D-sorbitol (CID: 5780) and gelatin were obtained from Sigma-Aldrich, Ireland. Coco-glucoside (CG), was supplied as Plantacare ® 818 UP (Cognis, Germany). Media, buffers and supplements were obtained from GIBCO ® , Ireland. Synthetic sCT (CID 16129616) was purchased from Polypeptide Laboratories (Copenhagen, Denmark); it had an average activity of 5100 I.U./mg. Transcutol HP ® (CID: 8146), Kolliphor EL ® (CID: 5849927), and Miglyol 810 ® (no CID) were obtained from Gattefossé (France), BASF (Germany), and Sasol (UK) respectively. BaSO 4 (Bariogel ® ) was purchased from Cristália SA (Brazil).
Opadry ® white and Surelease ® /Pectin were purchased from Colorcon (UK); Eudragit ® L30-D55 was from Evonik (UK). The Parameter TM cAMP ELISA was obtained from R&D Systems (UK).

Aguirre T.A.S., Aversa V., Rosa M., Guterres S.S., Pohlmann A.R., Coulter I, & Brayden D.J. (2016). Coated minispheres of salmon calcitonin target rat intestinal regions to achieve systemic bioavailability: Comparison between intestinal instillation and oral gavage. Journal of controlled release : official journal of the Controlled Release Society, 238.

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Macrocyclic Antibiotic Formulation Study

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The drug was a macrocyclic antibiotic (Figure 1) received (as a generous gift sample) from Unicure India. Isopropyl alcohol (IPA), dimethyl sulfoxide (DMSO), methanol, and acetonitrile were procured from Merck, (Mumbai, India). Capmul MCM C8 (CMC8) was received as a gift sample from BASF. Transcutol HP is, chemically, diethylene glycol monoethyl ether obtained from Gattefossé (Lyon, France).

Hussain A., Mahdi W.A., Alshehri S., Bukhari S.I, & Almaniea M.A. (2021). Application of Green Nanoemulsion for Elimination of Rifampicin from a Bulk Aqueous Solution. International Journal of Environmental Research and Public Health, 18(11), 5835.

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Formulation Development of Atovaquone Nanoparticles

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Atovaquone was purchased from Molekula (Irvine, CA, USA). Benzyl benzoate and polyethylene glycol (PEG) (average mol weight 200) were purchased from Sigma Chemical Co. (St. Louis, MO, USA). Isopropyl palmitate was purchased from Spectrum Laboratory Products, Inc. (New Brunswick, NJ, USA). Mineral oil, propylene glycol, and oleic acid were purchased from Fisher Scientific (Pittsburgh, PA, USA). Affinisol HPMC HME 15 LV was kindly donated from Dow Pharma & Food Solutions (Midland, MI, USA). Super-refined polysorbate 80-LQ-(MH), super-refined polysorbate 20-LQ-(MH), and super-refined PEG 400-LQ-(MH) were kindly donated from CRODA Inc. (East Yorkshire, UK). Kollidon VA64, Kollidon 30, and Cremophor RH 40 were kindly donated from BASF Corp. (Florham Park, NJ, USA). Capmul MCM NF and Captex 300 NF were kindly donated from Abitec Corp. (Jamesville, Rock County, WI, USA). Capryol 90, Transcutol HP, Labrafac lipophile WL 1349, Labrafil M 2125 CS, and Labrasol were obtained from Gattefosse SAS (Paramus, NJ, USA). All other chemical reagents used were of analytical grade.

Takabe H., Warnken Z.N., Zhang Y., Davis D.A., Smyth H.D., Kuhn J.G., Weitman S, & Williams III R.O. (2018). A Repurposed Drug for Brain Cancer: Enhanced Atovaquone Amorphous Solid Dispersion by Combining a Spontaneously Emulsifying Component with a Polymer Carrier. Pharmaceutics, 10(2), 60.

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Thymoquinone-Based Nanoemulsion Formulation

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Thymoquinone (99%) was obtained from UFC Biotechnology, (Buffalo, NY, USA). Oleic acid, ethyl oleate, castor oil, isopropyl myristate, isopropyl alcohol, sesame oil, PEG 400, tween 20, tween 80, and Kolliphor EL, Solutol HS were purchased from Sigma Aldrich (Hamburg, Germany), Black seed oil was purchased from Amazing Herbs, (Buford GA, USA). Caproyl 90 and Transcutol HP were purchased from Gattefosse (Saint-Proest France), Carbopol-940 was obtained from Lubrizol (Wickliffe, OH, USA). All other excipients were of pharmaceutical-grade reagent.

Algahtani M.S., Ahmad M.Z., Shaikh I.A., Abdel-Wahab B.A., Nourein I.H, & Ahmad J. (2021). Thymoquinone Loaded Topical Nanoemulgel for Wound Healing: Formulation Design and In-Vivo Evaluation. Molecules, 26(13), 3863.

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Solvent-Based ETP Extraction and Analysis Protocol

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ETP, teniposide (internal standard for ETP), methylcellulose (molecular weight: 60,000 Da), hexafluro-2-propanol, polyoxyethylene sorbitan monooleate (Tween 80), d-alpha-tocopherol polyethylene glycol succinate (TPGS), sodium carboxymethylcellulose (NaCMC), deoxycholic acid, chlorpromazine, methyl-β-cyclodextrin (MBCD), brefeldin A, genistein, actinomycin D, Cys A, ethylene glycol-bis-(2-aminoethyl ether)-N,N,N′,N′-Cys A, ethylene glycol-bis-(2-clofazimine) were obtained from Sigma-Aldrich Inc. (St. Louis, MO). Cellulase (105 U/mg) was purchased from Worthington Biochemical Corporation (Lakewood, NJ). Propylene glycol monocaprylate (Capryol 90), caprylocaproyl macrogol-8 glycerides (Labrasol), diethylene glycol monoethyl ether (Transcutol HP), and Tween 80 were provided by Gattefossé (Saint Priest, France). PA (10:0) was obtained from Avanti Polar Lipids (Alabaster, AL). All other chemicals for high-performance liquid chromatography (HPLC) and liquid chromatography/tandem mass spectrometry (LC/MS) analyses were obtained from Thermo Fisher Scientific Inc. (Waltham, MA).

Jha S.K., Han H.S., Subedi L., Pangeni R., Chung J.Y., Kweon S., Choi J.U., Byun Y., Kim Y.H, & Park J.W. (2020). Enhanced oral bioavailability of an etoposide multiple nanoemulsion incorporating a deoxycholic acid derivative–lipid complex. Drug Delivery, 27(1), 1501-1513.

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Formulation and Optimization of Lornoxicam Delivery

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Lornoxicam (LOR) was kindly provided by Al Jazeerah Manufacturing Co. Riyadh KSA. Larbafil M 2125 CS, Labrafac, Labrasol (caprylcaproyl macrogol glycerides), Transcutol HP (diethylene glycol monoethyl ether), Peceol (glyceryl monooleate) and Capmul®MCM were purchased from Gattefosse (Saint-Priest Cedex, France). Cremohpor® RH 40, Cremophor® EL, and Cremophor® ELP were purchased from BASF (Ludwigshafen, Germany). Oleic acid and ethyl oleate were procured from Acros Organics, USA. Isopropyl myristate (IPM), glycerol, Tween80, Tween20, PEG 400 (polyethylene glycol 400), 1,2-propylene glycol, methanol, and sodium acetate were purchased from BDH Laboratory Supplies (BDH Chemicals Ltd., Poole, England). High-purity water was obtained through a Milli-Q Integral Water Purification System (Millipore, Bedford, MA, USA). All other chemicals used were of analytical reagent grade.

Al-Suwayeh S.A., Badran M.M., Alhumoud G.O., Taha E.I., Ashri L.Y, & Kazi M. (2023). Design and dermatokinetic appraisal of lornoxicam-loaded ultrafine self-nanoemulsion hydrogel for the management of inflammation: In vitro and in vivo studies. Saudi Pharmaceutical Journal : SPJ, 31(6), 889-903.

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Ibuprofen Lipid-Based Formulation Development

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Ibuprofen (99.3% of purity, white crystalline powder) was purchased from Spectrum chemicals (New Brunswick, NJ, USA). All the lipid excipients Gelucire^® 44/14, Gelucire^® 48/16, Gelucire^® 50/13, Transcutol^® HP, and Maisine^® CC were kindly gifted by Gattefosse (Paramus, NJ, USA). The solid adsorbent carriers Neusilin^® US2 was gifted by Fuji chemical industries (Burlington, NJ, USA), Starch 1500^® (partially pregelatinized maize starch) was donated by Colorcon (Harleysville, PA), and Avicel PH^® 102 (microcrystalline cellulose) was donated by FMC Biopolymer (Philadelphia, PA, USA). All the disintegrants AC-DI-SOL^®, Sodium starch glycolate, and Kollidon-CL^® were donated by FMC Biopolymer (Philadelphia, PA, USA), Roquette (Geneva, IL, USA), and BASF (Ludwigshafen, Germany), respectively. The Slide-A-Lyzer^TM mini dialysis device with a molecular weight of 10 kDa was procured from ThermoFisher Scientific (Hampton, NH, USA). All other chemicals and solvents utilized in the current investigation are of analytical grade.

Nyavanandi D., Mandati P., Narala S., Alzahrani A., Kolimi P., Vemula S.K, & Repka M.A. (2023). Twin Screw Melt Granulation: A Single Step Approach for Developing Self-Emulsifying Drug Delivery System for Lipophilic Drugs. Pharmaceutics, 15(9), 2267.

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