At 4 and 12 weeks after surgery, T2-weighted midsagittal images of the IVDs were obtained using a 7·0-T MR scanner (Varian Unity Inova; Varian Medical Systems, Palo Alto, CA, USA) [2 (link),8 (link),16 (link)]. The Pfirrmann classification scheme (grade 5 was classified as severely degenerated) was used to grade IVD degeneration [20] (link). Quantitative analysis was also performed to determine the MRI index using analyze software version 12.0 (AnalyzeDirect, Overland Park, KS, USA). The MRI index (the product of NP area and average signal intensity) was applied for the quantification of alterations in NP and quantitative data were expressed as a percentage relative to the MRI index obtained with untreated control IVDs (relative MRI index) [2 (link),8 (link),16 (link)].
Analyze software version 12
Manufactured by AnalyzeDirect
Sourced in United States
Analyze software version 12.0 is a data analysis tool. It provides functionalities for processing and interpreting data. The software enables users to visualize, model, and analyze information from various sources.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using analyze software version 12
1
Quantitative MRI Analysis of Intervertebral Disc Degeneration
2
Bone Microarchitecture Analysis by μCT
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After the mice were killed, the femurs and fourth lumbar vertebrae (L4) were excised and fixed in 3.7% phosphate-buffered formalin. Subsequently, the bones were transferred to 70% ethanol and dried in air. Trabecular and cortical bone microarchitectures (femoral and lumbar) were assessed by performing high‐resolution microcomputed tomography (µCT) analysis. The µCT images were obtained using a Quantum FX micro CT system (PerkinElmer, Caliper Life Sciences, Hopkinton, MA, USA). The X-ray source was set to a voltage of 90 kVp, a current of 180 μA, and a field-of-view of 10 mm. Each distal femur was scanned in the region proximal to the growth plate and the fourth lumbar vertebra (L4) was scanned in the center of the vertebral body. Three-dimensional structural analyses of trabecular and cortical bone sites were performed using Analyze software, version 12.0 (AnalyzeDirect, Overland Park, KS, USA). Trabecular bone morphometry parameters were calculated for the BMD, bone volume/total volume (BV/TV) ratio, trabecular number (Tb.N), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp). In addition, cortical bone parameters, including the BMD, cortical area, and cortical thickness, were measured.
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