Skh 1 elite mice crl skh1 hrhr

All animal studies were carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals (81 ) and with the prior approval of the Animal Care and Use Committee of The Johns Hopkins University (MO12M223). Four- to five-week-old male and female SKH-1 Elite mice (Crl:SKH1-Hr^hr) and athymic nude mice [Crl:NU(NCr)-Foxn1^nu] were obtained from Charles River Inc. BALB/cJ mice (strain code 000651) were obtained from The Jackson Laboratory.

6–8 weeks old female C57BL/6J (strain code: 000664), BALB/cJ (strain code: 000651), Rag1 Knock-out (B6.129S7-Rag1^tm1Mom/J), CD4- Knockout (B6.129S2-Cd4 ^tm1Mak/J) and CD40 ligand knockout (B6.129S2-Cd40lg ^tm1Imx/J) were purchased from Jackson Laboratories Inc. Immunodeficient athymic Nude mice (Athymic NCr-nu/nu), SCID mice (NCI SCID/Ncr, BALB/c background) and immuno-competent SKH-1 elite mice (Crl:SKH1-Hr^hr) were obtained from Charles River, Inc. IFNAR knockout mice were a kind gift from Dr. G. Cheng (University of California, Los Angeles, CA) All animal studies were carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health and with the prior approval of the Animal Care and Use Committee of Johns Hopkins University (MO12M223).