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Mpp dihydrochloride

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MPP dihydrochloride is a chemical compound used in laboratory research. It functions as a selective inhibitor of monoamine oxidase B (MAO-B) enzyme activity.

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Lab products found in correlation

Tamoxifen citrate, by Bio-Techne (2 mentions) Myriocin, by Cayman Chemical (2 mentions) Pkcζ ps, by Bio-Techne (2 mentions) Dl pdmp, by Bio-Techne (2 mentions) G 6983, by Bio-Techne (2 mentions) G 6976, by Bio-Techne (2 mentions) Phtpp, by Bio-Techne (2 mentions) Diazoxide, by Merck Group (1 mentions) Nifedipine, by Merck Group (1 mentions) Wortmannin, by Bio-Techne (1 mentions) 17β oestradiol, by Merck Group (1 mentions) Pd98059, by Bio-Techne (1 mentions) Bicuculline, by Bio-Techne (1 mentions) L 655 708, by Bio-Techne (1 mentions) Raloxifene hydrochloride, by Bio-Techne (1 mentions) Micrococcal nuclease from staphylococcus aureus, by Merck Group (1 mentions) Phorbol myristate acetate (pma), by Merck Group (1 mentions) Gemcitabine, by Merck Group (1 mentions)

7 protocols using mpp dihydrochloride

1

Evaluation of Novel Signaling Modulators

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Tamoxifen citrate, ceramide, MPP dihydrochloride, G-1, Gö 6983, Gö 6976, PKCζ-PS and DL-PDMP were all obtained from Tocris Bioscience (Bristol, UK). Myriocin was obtained from Cayman Chemical (Ann Arbor, MI). Unless otherwise noted, all other chemicals were obtained from Sigma Aldrich.
Corriden R., Hollands A., Olson J., Derieux J., Lopez J., Chang J.T., Gonzalez D.J, & Nizet V. (2015). Tamoxifen Augments the Innate Immune Function of Neutrophils Through Modulation of Intracellular Ceramide. Nature communications, 6, 8369.
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2

Bisphenol-A and Estrogen Receptor Modulation

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Bisphenol-A was obtained from MP Biomedicals (Cat No 155118; Santa Ana, CA, USA). 17β-oestradiol (Cat No E8875), diazoxide (Cat No D9530), and nifedipine (Cat No D7634) were obtained from Sigma-Aldrich (Saint Louis, MO, USA). SNX-482 (Cat No 4363) was obtained from PeptaNova (Sandhausen, Germany). DPN (Cat No 1494), PPT (Cat No 1426), PHTPP (Cat No 2662), MPP dihydrochloride (Cat No 1991), PD98059 (Cat No 1213), and Wortmannin (Cat No 1232) were obtained from Tocris Cookson (Bristol, UK).
Villar-Pazos S., Martinez-Pinna J., Castellano-Muñoz M., Alonso-Magdalena P., Marroqui L., Quesada I., Gustafsson J.A, & Nadal A. (2017). Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca2+ entry in mouse pancreatic β-cells. Scientific Reports, 7, 11770.
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3

Hippocampal Slice Recordings and Object Location Memory

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For hippocampal slice recording, the compounds were infused into the aCSF bath via an independent perfusion line (6mL/hr). Final aCSF bath concentrations: APV (100 μM; Hello Bio #HB0225), bicuculline (20 μM; Tocris Bioscience #0130), L655,708 (field electrophysiology: 150 nM, whole-cell electrophysiology: 50 nM; Tocris Bioscience #1327), MPP dihydrochloride (3 μM; Tocris Bioscience #1991) were dissolved in DMSO (<0.01%). For the Object Location Memory task, vehicle (0.1% DMSO) or L655,708 (0.5mg/kg in 0.1% DMSO) was injected intraperitoneally 30 min prior to training.
Le A.A., Lauterborn J.C., Jia Y., Wang W., Cox C.D., Gall C.M, & Lynch G. (2022). Prepubescent female rodents have enhanced hippocampal LTP and learning relative to males, reversing in adulthood as inhibition increases. Nature neuroscience, 25(2), 180-190.
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4

Evaluation of Novel Signaling Modulators

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Tamoxifen citrate, ceramide, MPP dihydrochloride, G-1, Gö 6983, Gö 6976, PKCζ-PS and DL-PDMP were all obtained from Tocris Bioscience (Bristol, UK). Myriocin was obtained from Cayman Chemical (Ann Arbor, MI). Unless otherwise noted, all other chemicals were obtained from Sigma Aldrich.
Corriden R., Hollands A., Olson J., Derieux J., Lopez J., Chang J.T., Gonzalez D.J, & Nizet V. (2015). Tamoxifen Augments the Innate Immune Function of Neutrophils Through Modulation of Intracellular Ceramide. Nature communications, 6, 8369.
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5

Compound Acquisition for Research

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Raloxifene hydrochloride, MPP dihydrochloride, and PHTTP were purchased from Tocris Bioscience (Bristol, UK). PMA, micrococcal nuclease from Staphylococcus aureus, the small molecule library used for screening and all other compounds were obtained from Sigma-Aldrich (St. Louis, MO, USA).
Flores R., Döhrmann S., Schaal C., Hakkim A., Nizet V, & Corriden R. (2016). The Selective Estrogen Receptor Modulator Raloxifene Inhibits Neutrophil Extracellular Trap Formation. Frontiers in Immunology, 7, 566.
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6

Synthesis and Characterization of Bioactive Compounds

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E2 was purchased from Sigma-Aldrich. MPP dihydrochloride (1.3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidiny lethoxy)phenol)-1H-pyrazole dihydrochloride); PHTPPP (4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a) pyrimidin-3-yl)phenol) and G15 ((3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c] quinoline) were purchased from Tocris Biosciences (R&D system).
Dubois C., Rocks N., Blacher S., Primac I., Gallez A., García-Caballero M., Gérard C., Brouchet L., Noël A., Lenfant F., Cataldo D, & Pequeux C. (2019). Lymph/angiogenesis contributes to sex differences in lung cancer through oestrogen receptor alpha signalling. Endocrine-related cancer, 26(2).
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7

Selective Estrogen Receptor Antagonists

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The selective ERa antagonist (MPP dihydrochloride), ERb receptor antagonist (PHTPP), and GPR30 receptor antagonist (G15) used in this study were purchased from Tocris Bioscience (Ellisville, MO, USA). E2, DDP, and gemcitabine were purchased from Sigma (St. Louis, MO, USA). The ligands were prepared as 0.1 M stocks in DMSO or 100% ethanol and stored at -20°C. Prior to use, ligands were further diluted into cell culture medium for treatment groups.
Yu N., Dou L., Li Y., Deng L., Wei X, & Guo Y. (2016). Roles of ERα and ERβ in estrogen-induced DDP chemoresistance in non-small cell lung cancer. Genetics and molecular research : GMR, 15(3).
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