Pharmacokinetic parameters were determined using WinNonLin Pharmacokinetic Software, version 3.1 (Pharsight, Mountain View, CA). Non-compartmental modeling analysis was performed assuming first order input with uniform weighing. Extravascular dosing was chosen for the inhaled administration, while vascular dosing was chosen for the IV group. Plasma type modeling and linear trapezoid interpolation calculation were employed to get the desired PK parameters, which included Cmax, Tmax, half-life, AUC, clearance, volume of distribution, and terminal slope.
Winnonlin pharmacokinetic software
Manufactured by Pharsight
WinNonLin is a pharmacokinetic software package that enables users to perform nonlinear regression analysis on data from pharmacokinetic and pharmacodynamic studies. The software provides tools for data import, model selection, parameter estimation, and graphical display of results.
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Lab products found in correlation
2 protocols using winnonlin pharmacokinetic software
1
Pharmacokinetic Analysis of Drug Formulations
2
Noncompartmental Pharmacokinetic Analysis
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The concentration data from urine and plasma were used to calculate selected pharmacokinetic parameters with WinNonlin pharmacokinetic software, version 5.2.1 (Pharsight Corp, Sunnyvale, CA). We implemented a noncompartmental approach consistent with the IV bolus route of administration. Parameters were estimated using actual sampling times relative to the end of each dose administration. We calculated the area under the curve from the plot of plasma total radioactivity versus time, using the linear trapezoidal method with linear interpolation.
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