Clinical characteristics of patients, including age, sex, BMI, tobacco exposure and general physical examination were recorded. Patient’s fasting blood samples were collected within seven days before surgery and on follow-up to determine the levels of plasma fibrinogen and D-dimer. Biomarker levels were measured using an automatic analyzer (Stago STA Satellite®, France). Plasma fibrinogen and D-dimer were measured using the solidification and immune-turbidimetry method, respectively.
All patients underwent TURBT and intra-operative findings were recorded. The pathological diagnosis of tumor was established by a single pathologist, with > ten-years of experience in genitourinary malignancies, based on hematoxylin–eosin stained sections combined with immune-histochemical methods. Patient’s pathological characteristics including pathological stage and differentiation grade were recorded according to the UICC-TNM (2018) and WHO/ISUP (2004) classification, respectively.
Patients were followed up as per the NCCN-guidelines. The routine investigations at each follow-up consist of physical examination, blood investigations (including Plasma fibrinogen and D-dimer) and check cystoscopy. Excretory urogram and/or computed tomography (CT) was done to assess the upper urinary tract annually. The authors confirm the availability of, and access to all original data reported in this study.
All patients underwent TURBT and intra-operative findings were recorded. The pathological diagnosis of tumor was established by a single pathologist, with > ten-years of experience in genitourinary malignancies, based on hematoxylin–eosin stained sections combined with immune-histochemical methods. Patient’s pathological characteristics including pathological stage and differentiation grade were recorded according to the UICC-TNM (2018) and WHO/ISUP (2004) classification, respectively.
Patients were followed up as per the NCCN-guidelines. The routine investigations at each follow-up consist of physical examination, blood investigations (including Plasma fibrinogen and D-dimer) and check cystoscopy. Excretory urogram and/or computed tomography (CT) was done to assess the upper urinary tract annually. The authors confirm the availability of, and access to all original data reported in this study.