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C4767

Manufactured by Merck Group
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The C4767 is a laboratory equipment product manufactured by Merck Group. It is a device designed for scientific and research applications. The core function of the C4767 is to perform specific tasks related to laboratory procedures. However, a detailed description of its intended use or capabilities cannot be provided in an unbiased and factual manner within the given constraints.

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Lab products found in correlation

β cyclodextrin, by Merck Group (3 mentions) 2 hydroxypropyl cyclodextrin, by Merck Group (2 mentions) S3888, by Bio-Serv (2 mentions) S4207, by Bio-Serv (2 mentions) C2505, by Merck Group (1 mentions) Corticosterone, by Merck Group (1 mentions) Fluoxetine, by Biotrend (1 mentions)

5 protocols using c4767

1

Chronic Corticosterone Induces Depression-like Behavior

Cited 2 times
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Corticosterone (CORT) (27840, Sigma-Aldrich NV) was dissolved in b-cyclodextrin solution (4% in tap water, C4767, Sigma-Aldrich NV) to a concentration of 36.5 mg/L [51 (link)] and provided in drinking water over 4 weeks. This dose has been shown to induce depression and anxiety-like features in different mouse strains including blunting of corticosterone response following an acute stressor [51 (link), 52 (link)], while increasing the corticosterone levels less than what is observed after acute or chronic stress exposure [53 (link)–55 (link)]. Treatment was maintained during behavioural testing to prevent rebound effects. At the end of the behavioural tests, dorsal hippocampus was isolated and snap frozen.
Van Looveren K., Van Boxelaere M., Callaerts-Vegh Z, & Libert C. (2019). Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization. PLoS ONE, 14(12), e0226753.
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2

Corticosterone and Doxycycline Treatment Protocol

Cited 1 time
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CORT was prepared as previously described (David et al., 2009 (link)). Specifically, 35 μg/mL (equivalent to 5 mg/kg/day) CORT (27840; Sigma-Aldrich, St. Louis, MO, USA) was dissolved in 0.45% 2-hydroxypropyl cyclodextrin (332593; Sigma-Aldrich) and delivered in lightproof bottles, available ad libitum in drinking water. Control mice received 0.45% β-cyclodextrin in drinking water (C4767; Sigma-Aldrich). DOX was provided in chow containing 200 mg/kg DOX (S3888; Bioserv, Flemington, NJ, USA) fed ad libitum throughout life. Control chow (S4207; Bioserv) was used when DOX was withdrawn from the diet.
Besnard A., Langberg T., Levinson S., Chu D., Vicidomini C., Scobie K.N., Dwork A.J., Arango V., Rosoklija G.B., Mann J.J., Hen R., Leonardo E.D., Boldrini M, & Sahay A. (2018). Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses. Cell reports, 23(11), 3183-3196.
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3

Corticosterone and Fluoxetine Delivery

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35 μg mL−1 corticosterone (C2505, Sigma; St. Louis, MO) was dissolved in 0.45% β-cyclodextrin (C4767, Sigma; St. Louis, MO) in water. Fluoxetine (BG0197, Biotrend; Destin, FL) was dissolved at 160 μg mL−1. corticosterone (5 mg kg−1 day−1) was delivered in the drinking water either alone or in the presence of Fluoxetine (18 mg kg−1 day−1).
Wu M.V, & Hen R. (2014). Functional Dissociation of Adult-Born Neurons Along the Dorsoventral Axis of the Dentate Gyrus. Hippocampus, 24(7), 751-761.
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4

Corticosterone and Doxycycline Treatment Protocol

Cited 1 time
Check if the same lab product or an alternative is used in the 5 most similar protocols
CORT was prepared as previously described (David et al., 2009 (link)). Specifically, 35 μg/mL (equivalent to 5 mg/kg/day) CORT (27840; Sigma-Aldrich, St. Louis, MO, USA) was dissolved in 0.45% 2-hydroxypropyl cyclodextrin (332593; Sigma-Aldrich) and delivered in lightproof bottles, available ad libitum in drinking water. Control mice received 0.45% β-cyclodextrin in drinking water (C4767; Sigma-Aldrich). DOX was provided in chow containing 200 mg/kg DOX (S3888; Bioserv, Flemington, NJ, USA) fed ad libitum throughout life. Control chow (S4207; Bioserv) was used when DOX was withdrawn from the diet.
Besnard A., Langberg T., Levinson S., Chu D., Vicidomini C., Scobie K.N., Dwork A.J., Arango V., Rosoklija G.B., Mann J.J., Hen R., Leonardo E.D., Boldrini M, & Sahay A. (2018). Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses. Cell reports, 23(11), 3183-3196.
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5

Chronic Corticosterone Exposure Induces Depression-Anxiety

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Corticosterone (CORT) (27840, Sigma-Aldrich NV) was dissolved in b-cyclodextrin solution (4% in tap water, C4767, Sigma-Aldrich NV) to a concentration of 36.5 mg/L [51] (link) and provided in drinking water over 4 weeks. This dose has been shown to induce depression and anxiety-like features in different mouse strains including blunting of corticosterone response following an acute stressor [51, (link)52] (link), while increasing the corticosterone levels less than what is observed after acute or chronic stress exposure [53] (link)[54] (link)[55] (link). Treatment was maintained during behavioural testing to prevent rebound effects. At the end of the behavioural tests, dorsal hippocampus was isolated and snap frozen.
K V.L., M V.B., Callaerts-Végh Z., & Libert C. (2020). Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization. Yearbook of pediatric endocrinology.
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