Human alveolar basal epithelial carcinoma cell line a549

Methoxy poly(ethylene glycol) with  a number average molecular weight of 550 (MPEG550), ethanolamine, sodium hydride, silver sulfate, sodium diethyldithiocarbamate, phosphonitrilic chloride trimer and aluminium chloride were procured from Sigma-Aldrich. Anhydrous tetrahydrofuran was procured from Merck. Potassium tetrachloroplatinate(II) (Kojima Chemicals), potassium iodide (Junsei Chemicals) and ammonium hydroxide (Daejung Chemicals) were used as received. phosphonitrilic chloride trimer was purified by sublimation. cis-Diamminediaquoplatinum(II) sulfate was prepared from cis-diamminediiodoplatinum(II) as reported previously.17 (link) Poly(dichlorophosphazene) was prepared by thermal polymerization of phosphonitrilic chloride trimer in the presence of AlCl₃ catalyst as detailed in our earlier publication.18 (link) Human alveolar basal epithelial carcinoma cell line (A549) and human gastric cancer cell line (MKN-28) were purchased from Korean Cell Line Bank (Seoul, Korea). BALB/c nude mice (male, 5 weeks, 20 ± 2 g) and ICR mice (male, 5 weeks, 20 ± 2 g) were purchased from Orient Bio Inc. (Gyeonggi-do, Korea)

DTX and PTX were obtained from Samyang Genex (Daejeon, Republic of Korea). All other chemicals that are used for synthesis and animal studies, including MPEG550, THF, formic acid, dimethyl sulfoxide, and anhydrous ethanol, were supplied by Sigma-Aldrich (St Louis, MO, USA). Human alveolar basal epithelial carcinoma cell line (A549) and gastric tumor cell line (MKN-28) were obtained from Korean Cell Line Bank (Seoul, Republic of Korea). Male Sprague Dawley rats and BALB/C nude mice were supplied by Orient Bio Inc (Gyeonggi-do, Republic of Korea).