Naproxen nap

Naproxen (NAP, MW = 230.3 g/mol) was purchased from Sigma Aldrich (Steinheim, Germany). Indomethacin (IND, MW = 357.8 g/mol) and paracetamol (PAR, MW = 151.2 g/mol) were purchased from Fagron A/S (Copenhagen, Denmark). Celecoxib (CCX, MW = 381.4 g/mol) was purchased from Dr. Reddy’s (Hyderabad, India). Nifedipine (NIF, MW = 346.3 g/mol) was purchased from Hangzhou Dayangchem (Hangzhou, China). All materials were used as received.

Cladophora cellulose (CLAD) was provided by FMC Biopolymers (currently DuPont, Philadelphia, PA, USA). Microcrystalline cellulose (MCC) (Avicel PH101), ibuprofen (IBU), Ibuprofen-D3 (IBU-D3); Naproxen (NAP), Flurbiprofen (FLB), and Ketoprofen (KET) were purchased from Sigma Aldrich (Saint Louis, MO, USA). Biorelevant media of simulated gastric fluid (SGF), fasted simulated intestinal fluid (FaSIF), and fed state simulated intestinal fluid (FeSIF) were prepared using powder purchased from Biorelevant (London, UK) according to the manufacturer’s instructions. The chemical structures of studied profens are presented in Table 1. Table 1 summarizes the physical chemical properties of the arylpropionic acid derivaties under study.

Praziquantel (PZQ) was obtained from Divis Laboratories Ltd. (Telangana, India), loratadine (LOR) was purchased from Sris Pharmaceutials (Telangana, India), naproxen (NAP) was received from Sigma Aldrich (St. Louis, MO, USA), and celecoxib (CXB) was obtained from Cadila Pharmaceuticals Ltd. (Ahmedabad, India). Vinylpyrrolidone-vinyl acetate copolymer (copovidone, Kollidon^® VA 64, COP) was kindly donated by BASF SE (Ludwigshafen, Germany) (Table 1). All of the investigated APIs belong to BCS (Biopharmaceutics classification system) Class II and were thermally stable over the applied temperature range. None of the selected APIs were used to establish the T_g-melt viscosity correlation in the first place, and thus served for model validation [20 (link),21 (link)].