Kolliphor rh40

Alectinib hydrochloride was purchased from Wuhan Vanz Pharm Inc. (Wuhan, China). Kolliphor HS 15 (polyoxyl 15 hydroxy stearate), Kollisolv PEG 300 (polyethylene glycol 300), Kollisolv PEG 400 (polyethylene glycol 400), Kolliphor EL (polyoxyl 35 castor oil), Kolliphor PS 20 (Polysorbate 20), Kolliphor PS 80 (polysorbate 80), Kolliphor RH 40 (polyoxyl 40 hydrogenated castor oil), and Kollisolv MCT 70 (medium-chain capric triglyceride) were kindly provided by BASF (Ludwigshafen, Germany). Transcutol P (diethylene glycol monoethyl ether) and Capryol 90 (propylene glycol monocaprylate (type II)) were kindly provided by Gattefosse (Saint-Priest, France). Capmul MCM C8 (mono/diglycerides of caprylic acid) and Capmul MCM C10 (mono/diglycerides of capric acid) were kindly provided by ABITEC Corporation (Janesville, WI, USA). Sodium lauryl sulfate (SLS) was kindly provided by DUKSAN Pure Chemical (Ansan, Korea). All other chemicals were of reagent grade and were thus used without further purification.

Bovine bile, bovine serum albumin (BSA), calcein, cinnarizine, 4-bromophenylboronic acid (4-BPBA), maleic acid, pancreatin from porcine pancreas (≥3 × USP specifications), propylene glycol, soybean oil, and tris(hydroxymethyl)aminomethane (Tris) were purchased from Sigma Aldrich (St. Louis, MO, USA) at analytical grade. Acetonitrile (ACN), ammonium phosphate monobasic, ethanol absolute, hydrochloric acid (37%), methanol, potassium dihydrogen phosphate, and sodium hydroxide were purchased from VWR Chemicals (Leuven, Belgium). Kolliphor RH 40 and Maisine 35-1 were kindly donated by BASF (Ludwigshafen, Germany) and by Gattefossé (Saint-Priest, France), respectively. Lipoid S PC was obtained from Lipoid (Ludwigshafen, Germany). The PermeaPad^® barriers (25 mm) were generously donated by InnoME (Espelkamp, Germany). All water used in the experiments was of purified quality obtained from SG ultra-clear UV apparatus from Holm & Halby Service (Brøndby, Denmark).

AC1497 was obtained from Professor K. Lee (College of Pharmacy, Dongguk University) [5 (link)]. Labrafil M 2125CS, Labrafil M 1944 CS, Capryol 90, Labrasol, and Transcutol HP were provided by Gattefossé (Saint-Priest, Lyon, France). Captex 355, Capmul PG8, and Capmul MCM C8 were procured as a gift from ABITEC Corporation (Janesville, WI, USA). Kolliphor ELP, Kolliphor RH 40, and Solutol HS 15 were provided by BASF (Ludwigshafen, Germany). Dulbecco’s Modified Eagle’s Medium (DMEM), nonessential amino acids, fetal bovine serum (FBS), antibiotics (penicillin-streptomycin), and all other reagents used in cell culture studies were obtained from Thermo Fisher Scientific (Waltham, MA, USA). Other chemicals and solvents were purchased from Merck KGaA (Darmstadt, Germany). All solvents were of high-performance liquid chromatography (HPLC) grade.
Caco-2 cells (human epithelial colorectal adenocarcinoma cells) were purchased from the Korean Cell Line Bank (Seoul, Korea). Caco-2 cells were grown in DMEM containing 10% FBS, 1% nonessential amino acid, and 1% antibiotics. Cells were incubated at 37 °C in an atmosphere of 5% CO₂ and 90% relative humidity.

The sodium salt form of MTK was obtained from Kyongbo Pharm. (Asan, Chungnam, Korea). Polyvinylpyrrolidone K30 (PVP K30), Kollidon/vinylpyrrolidone-vinyl acetate (VA64) copolymer, Poloxamer-188, Poloxamer-407, Kolliphor RH40 (polyoxyl 40 hydrogenated castor oil), Kolliphor EL (polyoxyl castor oil), Kolliphor HS 15 (polyoxyl 15 hydroxystearate) were kindly provided by BASF Co. (Ludwigshafen, Germany). Hypromellose 2910 (HPMC 2910), and trifluoroacetic acid were purchased from Sigma Chemical Co. (St. Louis, MO, USA). Polysorbate 20 and polysorbate 80 were obtained from Masung & Co. Ltd. (Seoul, Korea). Pharma grade xanthan gum was purchased from Arthur Branwell Co. Ltd. (Essex, UK). Essex EssexLactic acid and sodium hydroxide standard solution (1 N) were acquired from Daejung chemical & metal Co. Ltd. (Gyeonggi-do, Korea). Sunset Yellow FCF (disodium 2-hydroxy-1-(4-sulfonatophenylazo)naphthalene-6-sulfonate) was obtained from Bolak Co. Ltd. (Gyeonggi-do, Korea). Acetonitrile (ACN) and methanol of HPLC (High-performance liquid chromatography) grade were provided by J.T. Baker (Phillipsburg, NJ, USA). All other reagents were analytical grade and were used without further purification.

Fucoidan with the average molecular mass 735 kDa was obtained from MMBI KSC RAS, Murmansk, Russia. Fucoidan was extracted from F. vesiculosus as described previously [25 (link)]. Poloxamer 407 (Kolliphor^® P 407), Polyoxyl 40 hydrogenated castor oil (Kolliphor^® RH40), polyethylene glycol 400 (Kollisolv^® PEG 400) were provided by BASF (Ludwigshafen, Germany). Extra-virgin olive oil was purchased at a local market. Diethylene glycol monoethyl ether (Transcutol^® P) was a gift from Gattefossé (Saint-Priest, France). Acepromazine (Fermenta Animal Health Co., Kansas City, MO, USA), ketamine (Fort Dodge Laboratories, Inc., Fort Dodge, IA, USA), xylazine (Miles Inc., Shawnee Mission, KS, USA), and other chemicals were used as received from the suppliers.