Bam8 18

Manufactured by Bio-Techne

Sourced in Canada

The BAM8-18 is a laboratory instrument manufactured by Bio-Techne. It is designed to facilitate the analysis and measurement of various biological samples. The core function of the BAM8-18 is to provide a controlled and consistent environment for conducting such analyses.

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Lab products found in correlation

Bam8 22, by Bio-Techne (2 mentions)

2 protocols using bam8 18

Investigation of Intradermal Neuropeptide Effects

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Ten minutes after applying the heat staircase, two blocks of intradermal injections (each 10 μl) were administered at the RF. One block consisted of extracellular fluid (ECF, the vehicle) followed by ALA (90 μg in ECF, Sigma-Aldrich, St Louis, MO), and another block of BAM8-18, the control peptide (1 μg in saline, synthesized in the Keck Lab, Yale University, New Haven, CT), followed by BAM8-22 (1 μg in saline, Tocris Bioscience). Each injection (volume 10 µl) was administered with a 28 G1/2 Lo-Dose syringe (Becton Dickenson, Franklin Lakes, NJ). The order of the blocks was randomized. Following each injection, neuronal activity was recorded for at least 5 min or until no neuronal activity was recorded for three consecutive minutes.

Klein A., Solinski H.J., Malewicz N.M., Ieong H.F., Sypek E.I., Shimada S.G., Hartke T.V., Wooten M., Wu G., Dong X., Hoon M.A., LaMotte R.H, & Ringkamp M. (2021). Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates. eLife, 10, e64506.

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Opioid Peptide Pharmacological Evaluation

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Met-enkephalin (1, 10, and 50 µg/5 µL) (MBS659922; MyBioSource), peptide E (1, 10, and 50 µg/5 µL) (30-3-25; American peptide, Sunnyvale, CA), bovine adrenal medullary peptide (BAM22, 0.5, 1, 10, and 50 µg/5 µL) (1650; Tocris), BAM8-22 (0.5, 1, 10, and 50 µg/5 µL) (1763; Tocris), and peptides synthesized by us for these experiments: FAE (0.5, 1, 10, and 50 µg/5 µL), VGR, known as BAM8-18 (0.5, 1, 10, and 50 µg/5 µL), and SPQ (1, 10, and 50 µg/5 µL) were used.

Piotrowska A., Starnowska-Sokół J., Makuch W., Mika J., Witkowska E., Tymecka D., Ignaczak A., Wilenska B., Misicka A, & Przewłocka B. (2020). Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Pain, 162(2), 432-445.

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