Bibb 515

The identity and purity of key small molecules were authenticated by LC–MS ( Data S3). The following compounds were purchased from Cayman Chemicals: Ro 48–8071, BIBB 515, 20-hydroxycholesterol, 27-hydroxycholesterol, 22(S)-hydroxycholesterol, 22(R)-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol, T0901317, GW 3965, WAY252623, and SR9238. Fenhexamid and CHIR-99021 were purchased from Sigma-Aldrich. VU 0255035 was purchased from Fisher. NB-598 was purchased from MedChemExpress. AGI-6780 and IWP-L6 were purchased from Selleck as DMSO stocks. Ciproxifan was purchased from Sigma Aldrich as a DMSO stock. The following standards were purchased from Toronto research chemicals: dioxidosqualene, mono-oxidosqualene, squalene. Details pertaining to all controls and GC-MS standards were reported previously.(Hubler et al., 2018 (link))
Methods and characterization of newly synthesized small molecules in included in Data S1-2.(Davis et al., 2003 (link), Wang et al., 1995 , Yang et al., 2018 (link), O’Keeffe et al., 2015 (link), Tomkinson et al., 1998 , Nakamura et al., 2009 , Maruoka et al., 1991 , Wu et al., 2010 , Emmons et al., 1989 , Shingate et al., 2013 , Shingate et al., 2011 , Jabbouri et al., 1991 , Nishitoba et al., 1988 , Jing et al., 2015 (link), Min et al., 1998 (link), Burns et al., 2018 (link))