Scans were acquired using a whole-body 3.0 Tesla (
3T) dStream MRI Scanner (Philips Healthcare, Best, The Netherlands) equipped with a volume transmit 32-channel receiver head coil (Nova Medical, Wilmington, Massachusetts, USA). The scanning protocol included: T1-weighted (T1W) fast field echo and T2-weighted (T2W) turbo spin echo (TSE), T2W fluid-attenuated inversion recovery (FLAIR) sequences, and a multi-b shells diffusion-weighted imaging sequence, the parameters of which are presented in
Table 2.
All the diffusion-weighted images were corrected using FMRIB Software Library (FSL) topup and eddy toolbox (
https://fsl.fmrib.ox.ac.uk/fsl/) to remove susceptibility and eddy current-induced distortions. After that, the neurite orientation dispersion and density imaging (NODDI) toolbox (
http://mig.cs.ucl.ac.uk/index.php?n=Tutorial.NODDImatlab) was used to reconstruct all the NODDI parametric maps (24 (
link)–26 (
link)). AD and V
ax were fitted as previously reported (27 (
link)).
Lastly, each map was co-registered and resampled to the T2W TSE image as an affine co-registration using the FMRIB's Linear Image Registration Tool (FLIRT) toolbox in FSL (
https://fsl.fmrib.ox.ac.uk/fsl/).
Yoon K., Archer D.B., Clarke M.A., Smith S.A., Oguz I., Cutter G., Xu J, & Bagnato F. (2022). Transcallosal and Corticospinal White Matter Disease and Its Association With Motor Impairment in Multiple Sclerosis. Frontiers in Neurology, 13, 811315.