Ml297

Manufactured by Merck Group

Sourced in United States

ML297 is a laboratory instrument designed for use in research environments. It is a multi-purpose device that can perform various analytical and experimental functions. The core function of ML297 is to facilitate scientific investigations and data collection in controlled laboratory settings. No further details or interpretation of the intended use are provided.

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Lab products found in correlation

Diazoxide, by Merck Group (1 mentions) Glybenclamide, by Merck Group (1 mentions) Pinacidil, by Merck Group (1 mentions) Tolbutamide, by Merck Group (1 mentions) S bayk8644, by Bio-Techne (1 mentions) R bay k 8644, by Bio-Techne (1 mentions) Am095, by Merck Group (1 mentions)

2 protocols using ml297

Synthesis and Characterization of Kir Channel Modulators

Cited 1 time

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The Kir channel inhibitor VU041 and the inactive analog VU937 were originally discovered in HTS against the Anopheles gambiae Kir1 channel^{3 (link)}. Both compounds were synthesized by Dr. Corey Hopkins at the Vanderbilt Center for Neuroscience Drug Discovery using methods described in Swale et al.^{3 (link)}. ML297, pinacidil, glybenclamide, tolbutamide, and diazoxide were purchased from Sigma-Aldrich (St. Louis, MO, USA). Chemical structures of the modulators used in this study are shown in Fig. 1.Figure 1

Chemical structures of Kir channel inhibitors used in this study.

Chen R, & Swale D.R. (2018). Inwardly Rectifying Potassium (Kir) Channels Represent a Critical Ion Conductance Pathway in the Nervous Systems of Insects. Scientific Reports, 8, 1617.

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Comprehensive Compound Acquisition for Research

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ML297 and AM095 were purchased from
Sigma-Aldrich (St. Louis, MO). (S)-(−)-BAY-K-8644,
(R)-(−)-BAY-K-8644, and SAK3 were obtained
from Tocris Bioscience (Bristol, UK). lysoPA18:1 was purchased from
Avanti Polar Lipids Inc. (Alabaster, AL). hC3a was purchased from
Complement Technology Inc. (Tyler, TX). Fluo-4AM was purchased from
Thermo Fisher Scientific Inc. (Waltham, MA). MK-8998, ST101, TTA-I1,
and TTA-A2 were synthesized in house. All other compounds were obtained
from Alomone Labs (Jerusalem, Israel).

Zhang Y.L., Moran S.P., Allen A., Baez-Nieto D., Xu Q., Wang L.A., Martenis W.E., Sacher J.R., Gale J.P., Weïwer M., Wagner F.F, & Pan J.Q. (2022). Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators. ACS Pharmacology & Translational Science, 5(3), 156-168.

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