3.0 t magnetom trio

Participants completed the task in the supine position in a magnetically shielded room while MEG data were recorded using a 151-channel CTF system (CTF MEG International Services LP, Coquitlam, BC, Canada). Data were sampled at 600 Hz with an online 0–150 Hz antialiasing filter, and a third-order spatial gradient applied to reduce environmental noise. Head location was continuously monitored using fiducial coils that were fitted at the left and right pre-auricular and nasion. Following scanning, the fiducial coils were replaced with radio-opaque markers for MRI co-registration. For co-registration, individual structural T1-weighted images were acquired on a Siemens 3.0 T MAGNETOM Trio with a 12 channel head coil (TR/TE = 2300/2.96 ms, FA = 9°, FOV = 240×256 mm, # slices = 192, resolution = 1.0 mm isotropic) scanner or, due to a scanner upgrade during the study, on a PrismaFIT with a 20 channel head and neck coil (TR/TE = 1870/3.14 ms, FA = 9°, FOV = 240×256 mm, # slices = 192, resolution = 0.8 mm isotropic) scanner.

LB subjects and their matched controls (MCs) were scanned on a 3 Tesla (ACHIEVA 3.0T TX, Philips) MRI scanner using an 8-channel phased-array head coil. High-resolution 3D T1-weighted magnetization prepared rapid acquisition gradient echo (T1W 3D TFE SENSE) images were acquired for anatomic reference (TR = 7.6 ms, TE = 3.5 ms, FA = 7°, 1.0 mm isotropic voxels). Functional data was acquired using an echo planar imaging (EPI) pulse sequence sensitive to BOLD contrast (TR = 3000 ms, TE = 30 ms, FA = 90°, 3.0 mm isotropic voxels), each run lasted 6 min 15 s. CB subjects and their MCs were scanned on a 3 Tesla (Siemens 3.0T Magnetom Trio) MRI scanner using an 8-channel phased-array head coil. Anatomical data were collected using a MPRAGE pulse sequence (TR = 2 ms, TE = 3.39 ms, FA = 9°, 1.33 mm isotropic voxels). Functional data were acquired using an EPI pulse sequence sensitive to BOLD contrast (TR = 6000 ms, TE = 30 ms, FA = 90°, 2 × 2 × 2 mm voxels), each run lasted 6 min 24 s. In all cases, head motion was restricted using a pillow and several foams, and earplugs were used to attenuate scanner noise. During the functional runs, participants were asked to stay awake with their eyes open for each of the BOLD runs and remain as still as possible.